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Vical Inc. (VICL)

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Last Post: 6/20/2016 6:07:07 PM - Followers: 69 - Board type: Free - Posts Today: 0

Corporate Profile

DNA Technology

Vical's proprietary core technology is based on plasmid DNA (pDNA), closed loops of DNA that encode any protein of interest. When injected into tissues such as skeletal muscle or the skin, cells take up pDNA and produce the encoded protein. This allows for pDNA to be used as the basis for a broad range of biopharmaceutical products: infectious disease vaccines (delivering antigens from viruses, bacteria, or parasites), cancer vaccines or immunotherapeutics (delivering tumor antigens or immunostimulatory proteins), and growth factors to stimulate angiogenesis and tissue repair in diseases such as cardiovascular disorders.

Since its initial discovery, Vical has continued to improve its DNA delivery technology so as to maximize gene expression as well as the body's response to the proteins produced. For example, we optimize the DNA sequences that make up our pDNA, and we continue to develop new formulation and delivery technologies, including the use of lipid molecules (which can function as vaccine adjuvants) and synthetic polymers such as poloxamers.

Plasmids are manufactured in Vical's cGMP facility in San Diego using uniform methods of bacterial fermentation and processing, which allows faster development and production times than technologies that require development of product-specific processes. In addition, since our product candidates contain no viral components they are designed to avoid unwanted immune responses, infections, or malignant changes in a cell's genetic makeup, and have been administered repeatedly with a very favorable safety profile in clinical trials to date.

Independent Programs

HSV-2 Vaccine (Phase1/2)

Corporate Collaborations

ASP0113 for HCT (Astellas Pharma)
ASP0113 for SOT (Astellas Pharma)
By United States Department of AgricultureONCEPT™ Canine Melanoma Vaccine (Merial)

Government Collaborations

Clinical Trials Overview

Vical has filed thirteen investigational new drug applications to conduct clinical trials and holds four master files for manufacturing recombinant DNA products.

Vical has completed more than thirty clinical trials with recombinant DNA products. These Phase 1 – Phase 3 trials of vaccines or gene therapy products have been conducted in up to 15 countries.

Check back frequently for updates on future enrollments or connect with us through RSS Feeds or connect with us on Vical on LinkedIn or Vical on Twitter.

Infectious Disease Vaccine Trials

Phase 3 Clinical Trial: ASP0113 Therapeutic Cytomegalovirus (CMV) Vaccine
A Study to Evaluate a Therapeutic Vaccine, ASP0113, in Cytomegalovirus (CMV)-Seropositive Recipients Undergoing Allogeneic, Hematopoietic Cell Transplant (HCT). For more information, please go to the NCT01877655 trial listing at

Phase 2 Clinical Trial: ASP0113 Therapeutic Cytomegalovirus (CMV) Vaccine 1
A Study to Evaluate the Efficacy and Safety of a Vaccine, ASP0113, in Cytomegalovirus (CMV)-Seronegative Kidney Transplant Recipients Receiving an Organ From a CMV-Seropositive Donor. For more information, please go to the NCT01974206 trial listing at

Phase 1/2 Clinical Trial: Safety and Efficacy Trial of DNA Vaccines to Treat Genital Herpes in Adults
A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation, Phase 1/2 Trial to Evaluate the Safety and Efficacy of Herpes Simplex Virus, Type 2 Therapeutic DNA Vaccines in Symptomatic HSV-2-Seropositive Adults. For more information, please go to the NCT02030301 trial listing at ?

Investor Overview


By synergizing vaccine and DNA technologies, Vical is creating new therapies, and shaping the future of vaccines.  Our vision is to realize the promise of novel preventive and therapeutic alternatives for serious and life-threatening diseases.


$VICL recent news/filings 
Many thanks to stocktrademan  for post #774



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Current Price
Bid Ask Day's Range
VICL News: Statement of Changes in Beneficial Ownership (4) 03/28/2017 04:52:29 PM
VICL News: Proxy Statement - Notice of Shareholders Meeting (preliminary) (pre 14a) 03/28/2017 04:48:22 PM
VICL News: Statement of Changes in Beneficial Ownership (4) 03/17/2017 04:44:47 PM
VICL News: Annual Report (10-k) 03/10/2017 04:04:01 PM
VICL News: Vical to Provide Company Update at the 29th Annual ROTH Conference 03/10/2017 06:30:00 AM
#968   It's all about selling on the news I Tough_to_make_money 06/20/16 06:07:07 PM
#966   Shareholders may need to worry about support levels, lemmy 06/20/16 04:37:58 PM
#965   Down 19 cents today (>4%). What quality!!!!!!! lemmy 06/20/16 04:28:48 PM
#963   Great news!! And thanks for the tip GP100 Tough_to_make_money 06/20/16 01:14:51 PM
#962   Good to see insiders buying Tough_to_make_money 06/16/16 06:45:24 PM
#961   Another 9k purchased today charliewho 06/14/16 11:37:14 PM
#960   Early PR. Tough_to_make_money 06/13/16 07:31:11 AM
#959   Nice find charliewho, I see here on insider Tough_to_make_money 06/12/16 08:49:52 PM
#958   3 insider purchases last week, NOT acquired......but purchased. charliewho 06/11/16 04:20:47 PM
#957   Nice early volume. Next resistance $5.50 charliewho 06/09/16 11:08:45 AM
#956   That's from April 26th. Gotta be "new" news charliewho 06/08/16 11:16:07 PM
#955   Maybe this Tough_to_make_money 06/08/16 03:26:05 PM
#954   Excellent volume today. Something cooking here charliewho 06/08/16 03:04:38 PM
#953   Never been that high. You forgot to factor Citrati 05/31/16 02:49:03 PM
#952   VICL News: Current Report Filing (8-k) 05/25/2016 09:01:42 AM mick 05/27/16 12:06:36 PM
#951   Vical Incorporated (VICL) mick 05/27/16 12:06:30 PM
#950   Reverse splits are almost always a LOSER'S ploy. lemmy 05/27/16 11:44:31 AM
#949   $VICL On May 20, 2016, the Company's $$$eeker 05/27/16 07:21:27 AM
#948   reverse split tomorrow spottrader 05/26/16 03:18:04 PM
#947   His position is the only reason the PPS basssque 05/20/16 08:26:49 PM
#946   best to sell now before Sheff does. This spottrader 05/19/16 12:57:25 PM
#945   AMDA $80 2 yrs ago and now under tkundrat 05/13/16 10:45:45 PM
#944   $heff Member Level Tuesday, 05/10/16 01:57:09 PM croptop 05/13/16 01:09:52 PM
#943   news out. what willbe the effect on the lngnstrng 03/10/16 04:11:53 AM
#942   I found the 8k from 2015. Warning issued. puravida 01/29/16 03:31:10 PM
#941   Has there been any notices from Nasdaq about puravida 01/29/16 11:53:04 AM
#940   This will be the next AMDA!!!! I see Lyubolesiv 01/28/16 11:06:53 AM
#939   VICL is the orphan, all right...34.5 cents, LOL. lemmy 01/13/16 01:06:12 AM
#938   VICL news: FDA Grants Vical Orphan Drug Designation LexTrader 01/06/16 07:30:11 AM
#937   Happy New Year to the Board goodplenty100 01/01/16 08:36:28 AM
#936   Thanks to Daniel Ward for the following goodplenty100 12/29/15 04:45:48 PM
#935 goodplenty100 12/22/15 05:01:01 PM
#934 goodplenty100 12/22/15 04:59:03 PM
#933   "VICL ...BUILDING STEAM...watching for .48 break" lemmy 12/21/15 01:29:05 PM
#932   Thanks and I 'll take a look..... seasonedwell 11/30/15 05:39:33 PM
#931   Welcome seasonedwell good to have you aboard! goodplenty100 11/30/15 05:03:05 PM
#930   You got it....... seasonedwell 11/30/15 01:23:50 PM
#929   VICL ...BUILDING STEAM...watching for .48 break Roy London 11/29/15 08:52:35 AM
#928   Vical has filed thirteen investigational new drug applications seasonedwell 11/26/15 10:52:22 AM
#927   Avg Vol (3 month): 256,106 seasonedwell 11/26/15 10:50:09 AM
#926   VICL selling for cash on the balance sheet..... seasonedwell 11/26/15 10:47:36 AM
#925   Shares Outstanding5: 91.52M seasonedwell 11/26/15 10:45:20 AM
#924   VICL, started a position here over the last week..... seasonedwell 11/26/15 10:44:36 AM
#923  Restored Pathetic garbage. Ole Vijay needs to do lemmy 11/16/15 02:45:58 PM
#922 goodplenty100 10/31/15 09:22:57 AM
#921   You're welcome ......... plenty more where that came Zardiw 10/30/15 09:21:13 AM
#920   Thanks for the peak goodplenty100 10/30/15 06:21:31 AM
#919   DDAmanda® Chart on: $VICL: Click on the chart Zardiw 10/29/15 10:21:44 PM
#918 goodplenty100 10/29/15 04:00:49 PM
#917   VICL~ makin' the muv's today! freshy 10/29/15 01:11:54 PM