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Sophiris Bio, Inc. (SPHS)

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Last Post: 1/17/2017 10:23:09 PM - Followers: 132 - Board type: Free - Posts Today: 0

Sophiris Bio Inc.

Sophiris Bio Inc. is a Canadian urology company with operations based in San Diego developing a late-stage, highly targeted treatment for benign prostatic hyperplasia (BPH or enlarged prostate), a large unsatisfied market. PRX302, the company’s lead candidate for BPH, is designed to be as efficacious as pharmaceuticals, less invasive than the surgical interventions, and without the sexual side effects seen with existing treatments. Sophiris is planning to begin a pivotal trial by the end of 2012.

The pivotal trial is supported by a randomized, controlled Phase IIb study that met the objective and subjective endpoints used as the basis for current BPH drug approvals. Sophiris is advised by world-leading urologists, is backed by experienced investors, and is led by an experienced drug development team that has achieved more than twenty drug approvals including several blockbusters.


Ongoing Clinical Development
Study Phase Trial Design
PRX302-3-01 BPH


III On-going/Enrollment Completed (479 patients) Prospective, randomized, double-blind, placebo-controlled, transrectal treatment of PRX302, which will utilize the IPSS outcome measure evaluated at 12 months as the primary endpoint
PRX302-2-7 PCa


IIa Enrolling (approximately 20 patients) Open label, Phase 2a study, evaluating the safety and tolerability of targeted intraprostatic administration of PRX302 to treat men with histologically proven, clinically significant, localized, low to intermediate risk prostate cancer

Completed Clinical Development

Study Phase
(pts treated with PRX302
Trial Design
PRX302-2-03 BPH
IIb (61 pts) Randomized, double-blind, placebo-controlled, transperineal treatment of PRX302
PRX302-2-06 BPH I/II (32 pts) Randomized dose escalation, multicenter trial of a single transrectal intraprostatic treatment of PRX302
Phase 2a BPH
IIa (18 pts) Open-label, safety, volume escalation clinical trial of a single transperineal treatment of PRX302
I (15 pts) Open-label, safety, dose escalation clinical trial of a signal transperineal intraprostatic treatment of PRX302
PRX302 PCa I (24 pts) Open-label, safety and tolerability, dose escalation trial of PRX302 in patients with biopsy-proven, locally-recurrent prostate cancer
PRX302 PCa II (6 pts) Open-label clinical trial in locally-recurrent prostate cancer

$SPHS was $40.00 in 2011 We will be back there soon enough.
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Current Price
Bid Ask Day's Range
SPHS News: Amended Statement of Ownership (sc 13g/a) 01/11/2017 02:32:03 PM
SPHS News: Securities Registration: Employee Benefit Plan (s-8) 12/21/2016 04:14:10 PM
SPHS News: Statement of Changes in Beneficial Ownership (4) 12/09/2016 04:11:22 PM
SPHS News: Statement of Changes in Beneficial Ownership (4) 12/09/2016 04:10:30 PM
SPHS News: Statement of Changes in Beneficial Ownership (4) 12/09/2016 04:10:03 PM
#2715   SAN DIEGO and VANCOUVER, British Columbia, May 12, nymostwanted 01/17/17 10:23:09 PM
#2714   How can anyone know? pgh_maulers 01/17/17 05:46:32 PM
#2713   A deal of some sort is very close salgovernale69 01/17/17 05:12:30 PM
#2712   Beautiful summary ;) nymostwanted 01/17/17 04:47:18 PM
#2711   They are in an extended quiet period due djpope 01/17/17 01:28:47 PM
#2710   I think their policy is "won't respond to Lnp30 01/17/17 08:53:57 AM
#2709   Company will not disclose to one shareholder they nymostwanted 01/16/17 05:40:08 PM
#2708   I have sent emails to the company and pgh_maulers 01/16/17 05:38:29 PM
#2707   Short it or don't buy. Not my job nymostwanted 01/16/17 05:31:35 PM
#2706   Well you seem to know all why ask questions?? nymostwanted 01/16/17 05:30:11 PM
#2705   Why would you say buyout soon? pgh_maulers 01/16/17 05:29:22 PM
#2704   No one knows that answer for sure but nymostwanted 01/16/17 11:43:24 AM
#2703   Buyout before May? LearnToTrade 01/16/17 06:47:23 AM
#2702   Has anyone confirmed or does anyone know for pgh_maulers 01/15/17 09:58:37 PM
#2701   He has the wrong board for sure. rosemountbomber 01/15/17 02:44:27 PM
#2700   For SPHS? Do you have a link by chance? EasyRider 01/15/17 02:17:07 PM
#2699   Tender Offer. This Schedule 14D-9 relates to the tender LearnToTrade 01/15/17 10:27:46 AM
#2698   For the benefit of anyone new to the melaurian 01/14/17 05:37:41 PM
#2697   Yes to all of your questions, i have nymostwanted 01/13/17 11:48:51 AM
#2695   I'm just sitting with my 15.5k shares (free Lnp30 01/12/17 11:37:28 PM
#2694   Yes sir . nymostwanted 01/12/17 11:28:00 PM
#2693   You did go big on this eh? Lnp30 01/12/17 11:27:30 PM
#2692   Long weekend ahead maybe shorts are getting scared nymostwanted 01/12/17 01:31:56 PM
#2691   In need of some company update ... nymostwanted 01/11/17 07:37:46 PM
#2690   Just to clarify, mr Hintz own indirectly as EnricoMania 01/11/17 05:21:46 PM
#2689   Sabby and his vehicles totally own 17,14% of $SPHS EnricoMania 01/11/17 05:02:43 PM
#2688   Hopefully a sweet deal for all longs ?? oh_no 01/10/17 07:28:01 PM
#2687   Waiting for the PR right now, a long oh_no 01/10/17 07:26:37 PM
#2686   Took a position here after reading solid financials EnricoMania 01/10/17 05:02:27 PM
#2685   SAN DIEGO and VANCOUVER, British Columbia, May 12, nymostwanted 01/10/17 08:35:58 AM
#2684   ARIA bought out today at $5.2B... our time EasyRider 01/09/17 09:19:37 PM
#2683   Bring us a $3.50 today come on.. nymostwanted 12/27/16 12:53:39 PM
#2682   Season's Greetings melaurian 12/17/16 03:23:25 PM
#2681   SPHS $3.10 ClearlyStocks 12/13/16 10:30:16 AM
#2680   SPHS $3 ClearlyStocks 12/13/16 10:28:39 AM
#2679   You guys should offer again when it really beebop_rocksteady 12/10/16 12:48:19 PM
#2678   Yes but says exercise price of $2.74 ! nymostwanted 12/09/16 09:15:51 PM
#2677   I read options, not buys, yes? EasyRider 12/09/16 09:08:30 PM
#2676   8k filed .. maybe Monday some news about nymostwanted 12/09/16 05:30:31 PM
#2675   Sweet inside buyers up we go ... nymostwanted 12/09/16 04:55:48 PM
#2674   We have $SPHS Tee Shirts, only a few melaurian 12/08/16 05:26:18 PM
#2673   Does the 21st Century Cures Act have application cabbieJBJ 12/08/16 08:42:03 AM
#2672   Santa Claus news .. nymostwanted 12/07/16 01:05:32 PM
#2671   What news are we expecting? K-Pax 12/07/16 12:48:08 PM
#2670   Oh well this thing is waiting on some nymostwanted 12/06/16 04:45:20 PM
#2669   I feel there is a spike coming today. nymostwanted 12/06/16 02:06:53 PM
#2668   Nice move today!!!! News in the pipeline? Anyone Fuddynut 11/29/16 11:38:33 AM
#2667   Great summary for a buyout ... nymostwanted 11/21/16 09:01:32 PM
#2666   Great info. But, sounds like other than a K-Pax 11/21/16 08:29:31 PM
#2665   Sphs is currently in search of funding for HeresJonny 11/21/16 04:27:35 PM