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Sophiris Bio, Inc. (SPHS)

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Last Post: 10/20/2016 10:45:21 AM - Followers: 137 - Board type: Free - Posts Today: 0
Sophiris Bio Inc.

Sophiris Bio Inc. is a Canadian urology company with operations based in San Diego developing a late-stage, highly targeted treatment for benign prostatic hyperplasia (BPH or enlarged prostate), a large unsatisfied market. PRX302, the company’s lead candidate for BPH, is designed to be as efficacious as pharmaceuticals, less invasive than the surgical interventions, and without the sexual side effects seen with existing treatments. Sophiris is planning to begin a pivotal trial by the end of 2012.

The pivotal trial is supported by a randomized, controlled Phase IIb study that met the objective and subjective endpoints used as the basis for current BPH drug approvals. Sophiris is advised by world-leading urologists, is backed by experienced investors, and is led by an experienced drug development team that has achieved more than twenty drug approvals including several blockbusters.


Ongoing Clinical Development
Study Phase Trial Design
PRX302-3-01 BPH


III On-going/Enrollment Completed (479 patients) Prospective, randomized, double-blind, placebo-controlled, transrectal treatment of PRX302, which will utilize the IPSS outcome measure evaluated at 12 months as the primary endpoint
PRX302-2-7 PCa


IIa Enrolling (approximately 20 patients) Open label, Phase 2a study, evaluating the safety and tolerability of targeted intraprostatic administration of PRX302 to treat men with histologically proven, clinically significant, localized, low to intermediate risk prostate cancer

Completed Clinical Development

Study Phase
(pts treated with PRX302
Trial Design
PRX302-2-03 BPH
IIb (61 pts) Randomized, double-blind, placebo-controlled, transperineal treatment of PRX302
PRX302-2-06 BPH I/II (32 pts) Randomized dose escalation, multicenter trial of a single transrectal intraprostatic treatment of PRX302
Phase 2a BPH
IIa (18 pts) Open-label, safety, volume escalation clinical trial of a single transperineal treatment of PRX302
I (15 pts) Open-label, safety, dose escalation clinical trial of a signal transperineal intraprostatic treatment of PRX302
PRX302 PCa I (24 pts) Open-label, safety and tolerability, dose escalation trial of PRX302 in patients with biopsy-proven, locally-recurrent prostate cancer
PRX302 PCa II (6 pts) Open-label clinical trial in locally-recurrent prostate cancer

$SPHS was $40.00 in 2011 We will be back there soon enough.
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Current Price
Bid Ask Day's Range
SPHS News: Current Report Filing (8-k) 10/14/2016 04:03:08 PM
SPHS News: Sophiris Bio to Present at the 2016 BIO Investor Forum 10/10/2016 04:00:00 PM
SPHS News: Sophiris Bio Closes Underwritten Public Offering 08/26/2016 04:01:00 PM
SPHS News: Statement of Ownership (sc 13g) 08/26/2016 09:38:51 AM
SPHS News: Statement of Ownership (sc 13g) 08/25/2016 09:46:44 AM
#2640   agree SPHS showing buying strength the last few blackbandit 10/20/16 10:45:21 AM
#2639   At some point we will have to break nymostwanted 10/19/16 10:39:52 AM
#2638   I won't be surprised to see $4 by nymostwanted 10/19/16 10:39:15 AM
#2637   added to watchlist mikekrane 10/18/16 08:42:53 AM
#2636   Interesting....excellent post mate. Optionsrbest4u 10/17/16 11:53:49 AM
#2635   New Board Member appointed at SPHS, filing here melaurian 10/15/16 04:05:02 PM
#2634   SPHS green 3 of last 4 days. maybe blackbandit 10/14/16 10:13:44 AM
#2633   Common prostate cancer treatment linked to dementia risk djpope 10/13/16 06:09:50 PM
#2632   SPHS has closed green 2 days in a blackbandit 10/11/16 04:39:28 PM
#2631   has SPHS stated when they plan to file blackbandit 10/10/16 08:38:54 PM
#2630   they just added 26mil$$ to the coffers a blackbandit 10/07/16 01:37:00 PM
#2629   You really haven't done any DD have you. Ortho91 10/07/16 01:07:30 PM
#2628   Is the SPHS cash position as dire as Optionsrbest4u 10/07/16 12:10:44 PM
#2627   Wow I said bull. Bear flag my mistake hwpbnj 10/07/16 07:35:50 AM
#2626   most all small bio's red so far today. blackbandit 10/06/16 02:49:22 PM
#2625   Can't hold above 3 bucks anymore. hwpbnj 10/06/16 01:59:04 PM
#2624   Slowly bleeding. Bull flag formed. Should have listened hwpbnj 10/06/16 01:58:09 PM
#2622   Stocks relying on news isn't good enough to hwpbnj 10/05/16 03:19:51 PM
#2621   Actually it's looking bad. Stop telling people this hwpbnj 10/05/16 03:17:49 PM
#2620   drop before news release? ming1234 10/05/16 10:35:10 AM
#2619   agree, welcome and looks like strong support around blackbandit 10/05/16 10:33:36 AM
#2618   its riding the $3 consolidation line now. Will blackbandit 10/05/16 09:53:22 AM
#2617   Maybe hwpbnj 10/04/16 08:52:55 AM
#2616   As much as I don't want to agree Lnp30 10/04/16 08:48:38 AM
#2615   Where did U get New Jersey from hwpbnj 10/04/16 08:22:14 AM
#2614   Lol. hwpbnj 10/04/16 08:21:02 AM
#2609   Don't worry it'll bounce really nice from that hwpbnj 10/04/16 07:32:20 AM
#2608   Whatever you think. Just remember who told u hwpbnj 10/04/16 07:30:05 AM
#2605   Low 2 dollar mark coming hwpbnj 10/01/16 09:43:13 PM
#2604   Past articles, news items and presentations re: SPHS melaurian 10/01/16 11:27:27 AM
#2603   why, what makes you say this isn't a brooklyn13 09/30/16 06:38:38 PM
#2602   Should sell and buy on the next dip hwpbnj 09/30/16 02:32:19 PM
#2601   When will the buy out happen? Any enthusiast? marina22 09/30/16 01:38:48 PM
#2600   Jumped in here at about $3, that seems brooklyn13 09/30/16 11:29:24 AM
#2598   Yeah! Itz solid uptrend ... mike007 09/27/16 10:15:25 AM
#2597   Lets get 3.50 in the rear view mirror, blackbandit 09/27/16 10:06:32 AM
#2596   Big new or news come in ! mike007 09/27/16 10:02:21 AM
#2595   agree, I only held DRRX out of those blackbandit 09/27/16 09:23:10 AM
#2594   PTIE was a one trick pony, DRRX has brooklyn13 09/27/16 05:56:01 AM
#2593   One has to start to scratch their head Lnp30 09/27/16 02:34:11 AM
#2592   those 2 will be back IMO, just will blackbandit 09/26/16 10:16:55 PM
#2591   I'm almost all bios, got killed today in brooklyn13 09/26/16 10:05:23 PM
#2590   Dawson James Securities 2016 Small Cap Growth Stock blackbandit 09/26/16 10:01:06 PM
#2589   SPHS starting back up is a bright spot, blackbandit 09/26/16 09:55:47 PM
#2588   I certainly hope so for your sake - brooklyn13 09/26/16 09:47:19 PM
#2587   it's not, LOL. one tidbit of good news blackbandit 09/26/16 09:40:17 PM
#2586   bklyn, almost back to that 3.50 area in blackbandit 09/26/16 09:38:26 PM
#2585   Hahaaa... mike007 09/26/16 03:20:25 PM
#2584   For newbies only; selected SPHS news and articles: melaurian 09/25/16 11:54:31 AM
#2583   Can you explain how its going from 7.60 mike007 09/23/16 01:29:47 PM