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Oxis International Inc. (OXIS)

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Last Post: 10/14/2016 11:48:03 AM - Followers: 141 - Board type: Free - Posts Today: 0


Oxis International Inc.

Below shows OXS-1550 WORKING - Soon to enter Phase II with FDA!


Treating Non-Hodgkin's lymphoma

OXS-1550 targets cancer cells expressing the CD19 receptor or CD22 receptor or both receptors. When OXS-1550 binds to cancer cells, the cancer cells internalize OXS-1550 and are killed due to the action of drug's cytotoxic payload. OXS-1550 has demonstrated success in early human clinical trials in patients with relapsed/refractory B-cell lymphoma or leukemia.

Treating triple-negative breast cancer

Our lead drug candidate, OXS-2175, is a small molecule therapeutic candidate targeting the treatment of triple-negative breast cancer. In in vitro and in vivo models of TNBC, OXS-2175 demonstrated the ability to inhibit metastasis.

Treating multiple myeloma

Our lead drug candidate, OXS-4235, also a small molecule therapeutic candidate, targets the treatment of multiple myeloma and associated osteolytic lesions. In in vitro and in vivo models of multiple myeloma and osteoporosis, OXS-4235 demonstrated the ability to kill multiple myeloma cells, and decrease osteolytic lesions in bone.



Company Website


Corporate Overview - Presentation
Fall 2015
Click the link:





OXIS Conference Call  March 31, 2015

CEO Interview with The Wolf of Weedstreet




Sean Xie, MD, PhD, EMBA is a tenured Professor at the Department of Pharmaceutical Sciences/Drug Discovery Institute at University of Pittsburgh and Associate Dean for Research Innovation at the School of Pharmacy. He is Principal Investigator of an integrated research laboratory of CompuGroup, BioGroup and ChemGroup, and Founding Director of Computational Chemical Genomics Screening Center. Dr. Xie is also Director/PI of NIH funded National Center of Excellence for Computational Drug Abuse Research. Dr. Xie holds joint faculty positions at the Departments of Computational System Biology and Structural Biology, and Pittsburgh Cancer Institute MT/DD Program. He serves as an invited guest editor for AAPS Journal, Editorial Board of American Journal of Molecular Biology, and Associate Editor of BMC Pharmacology and Toxicology. In 2013, he was named an honorary professor of Chinese Academy of Medical Sciences & Peking Union Medical College. Dr. Xie is a recipient of the 2014 American Association of Pharmaceutical Scientists (AAPS) Outstanding Research Achievement Award.


Dr. James J. Mule, Ph.D. serves as an Executive Vice President and Associate Center Director for Translational Research, the Michael McGillicuddy Endowed Chair for Melanoma Research and Treatment, and the Co-Director of the Donald A. Adam Comprehensive Melanoma Center at the Moffitt Cancer Center. He then moved to Palo Alto, Calif., where he was involved in the birth of two startup companies while an adjunct faculty member in the Department of Surgery, Stanford University. He moved to Ann Arbor, Mich., as the Director of the Tumor Immunology and Immunotherapy Clinical Research Programat the University of Michigan Comprehensive Cancer Center. Dr. Mule is recognized for his translational research studies in cancer immunotherapy. His research group is involved in vaccine strategies and other approaches to stimulate the immune system to recognize and destroy tumors. The work in these areas has helped to develop new treatments for advanced cancer patients. Dr. Mule serves on the Advisory Boards of seven NCI-designated Cancer Centers and was a member of the NCI’s Board of Scientific and Clinical Counselors. He serves as Chair of the Cellular, Tissue and Gene Therapy Advisory Committee of CBER, FDA, is a Special Government Employee of the NCI and the FDA. Dr. Mule is recognized for his research and clinical contributions to cancer immunotherapy, particularly in solid tumors.


Dr. Stephen M. Chang is Vice President-Research & Development at New York Stem Cell Foundation, Chief Scientific Officer at Stemgent, Inc., and Independent Director at MultiCell Technologies, Inc. He is on the Board of Directors at MultiCell Technologies, Inc. Dr. Chang was previously employed as Chief Scientific Officer & Vice President by Canji, Inc., Chief Scientific Officer & Vice President by Schering-Plough Research Institute, and President & Chief Executive Officer by MultiCell Immunotherapeutics, Inc. He also served on the board at Histogen, Inc. He received his undergraduate degree from the University of Michigan and a doctorate degree from the University of California, Irvine.


Dr. Haile has special technical experience in molecular biology, immunology, plant biotechnology, including transgenic plants, cell biology, diagnostics, therapeutics, theranostics, virology, drug delivery systems, host-vector systems, high throughput screening and bioinformatics. She has particular experience with patentability, non-infringement and validity opinions; licensing strategies; FDA counseling; due diligence work in connection with venture capital, private and public financing; mergers and acquisitions in the life sciences industry; and strategic counseling for comprehensive life sciences patent portfolio management. Dr. Lisa Haile concentrates on patent protection.


Information on Multiple Myeloma & Cannabidiol (CBD)

After studying the effects of cannabidiol on multiple myeloma cells, researchers found that; “CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells.”

They conclude that; “These data provide a rationale for using CBD to increase the activity of proteasome inhibitors in MM.”

The study, which validates a recent National Institute of Health study which also found that cannabidiol can inhibit cancer cells, was conducted by researchers at the School of Pharmacy at the University of Camerino in Italy.


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Current Price
Bid Ask Day's Range
OXIS News: Securities Registration Statement (s-1/a) 10/03/2016 06:06:05 AM
OXIS News: Securities Registration Statement (s-1/a) 08/25/2016 06:01:53 AM
OXIS News: Securities Registration Statement (s-1) 08/24/2016 06:01:43 AM
OXIS News: Quarterly Report (10-q) 08/10/2016 04:08:22 PM
OXIS News: Current Report Filing (8-k) 08/09/2016 06:10:58 AM
#7727  Sticky Note $OXIS - OXS-1550 (DT2219) SUCCESS 136 03/29/16 09:15:29 PM
#8250   I'd bet ya the downtrend continues, but I Halks1122 10/14/16 11:48:03 AM
#8249   We're not far off. We'll know in the CashBowski 10/13/16 06:57:02 PM
#8248   o Fibanotch 10/13/16 02:30:36 PM
#8247   .05 looks good Fibanotch 10/13/16 02:18:20 PM
#8246   Who knows IR has never responded to my djmurdock 10/13/16 01:38:00 PM
#8245   OXIS Your company is crashing to the floor Dip66 10/13/16 01:00:33 PM
#8244   Same brandao 10/12/16 11:55:46 PM
#8243   From a technical perspective, this bounced off nicely Halks1122 10/12/16 03:41:16 PM
#8242   OXIS' TriKE Cancer-Fighting Platform Receives Favorable News Coverage TPX 10/08/16 06:23:17 PM
#8241   Good advice! 6 months , from .60 down Fibanotch 10/06/16 06:25:31 PM
#8240   8K BAMBOOZLER 10/06/16 04:37:05 PM
#8239   This is one of the few dogs in ChillinCharlie 10/06/16 11:00:22 AM
#8238   Thanks, I missed that PR couple days ago. CashBowski 10/06/16 08:56:06 AM
#8237   Is the one from 10/03/2016 different and additional? simon wagstaff 10/06/16 08:15:21 AM
#8236   Yes, they did on/about 8/24/16 and I'm not CashBowski 10/06/16 07:58:04 AM
#8235   As for the dilution being over a month simon wagstaff 10/06/16 07:19:44 AM
#8234   I don't quite understand. I come up with simon wagstaff 10/05/16 09:54:25 AM
#8233   dilution finished a month or so ago, heavy animaljive 10/05/16 08:26:00 AM
#8232   how did you know? might jump in tomoro vlay 10/04/16 11:11:40 PM
#8231   psssst biei animaljive 09/30/16 10:37:45 AM
#8230   The downward pressure continues... CashBowski 09/27/16 06:48:35 PM
#8229   Choked on this one heaviestD 09/22/16 11:28:33 AM
#8228   What Milestones? vlay 09/21/16 10:44:00 AM
#8227   Milestones approaching $OXIS 136 09/21/16 12:29:26 AM
#8226   Someone cut these guys a check for a Dip66 09/19/16 02:16:00 PM
#8225   Anthony/Steve - You guys get funding yet?? Let's Dip66 09/16/16 11:27:04 AM
#8224   The dumping comes in waves. The chart tells Halks1122 09/12/16 07:50:04 PM
#8223   Many good things happening... patience. Gibba 09/12/16 11:38:14 AM
#8222   It's a good thing that its been somewhat CashBowski 09/12/16 07:40:17 AM
#8220   Oxis Biotech to Discuss its Cancer-Fighting Platforms at TPX 09/08/16 09:59:05 AM
#8219   OXIS Oxis Biotech's TriKE Cancer-Fighting Technology Receives Key TPX 08/29/16 10:02:41 AM
#8218   150 mil authorized and 28 mil OS as CashBowski 08/25/16 01:43:05 PM
#8217   Does anyone know, or can it be determined Gibba 08/25/16 12:16:05 PM
#8216   I seriously doubt it. They will likely need CashBowski 08/25/16 06:17:04 AM
#8215   Um, no. Rapture2020 08/25/16 03:29:53 AM
#8214   Could this open the door to institutional ownership Gibba 08/24/16 03:05:15 PM
#8213   Another public offering of common stock and related CashBowski 08/24/16 02:50:47 PM
#8212   Any thoughts on today's news? Gibba 08/24/16 12:16:25 PM
#8211   Do you remember that part of 10K ? M163648 08/19/16 12:26:07 PM
#8210   Looks now to be a day traders paradise. Gibba 08/17/16 11:21:40 AM
#8209   It was at $3.00+ end of February and Gibba 08/17/16 01:08:32 AM
#8208   And exactly when was this at $3.00? Rapture2020 08/16/16 10:36:19 PM
#8207   Would be nice to see this back at Dip66 08/16/16 11:53:50 AM
#8206   OXIS Oxis Biotech Scientific Advisory Board Member to TPX 08/16/16 07:39:42 AM
#8205   Keep momentum going? Lol. Rapture2020 08/16/16 06:51:14 AM
#8204   I suspect we will get some good news Gibba 08/15/16 09:36:57 PM
#8203   Good day today, probably a bounce off earnings. CashBowski 08/15/16 07:18:16 PM
#8202   10q was good. $OXIS is a solid investment. Gibba 08/15/16 11:39:45 AM
#8201   OXIS on the move. These guys onto something Dip66 08/15/16 10:51:58 AM
#8200   OXIS is starting the Monday morning off RIGHT! 2kimberly 08/15/16 10:08:01 AM