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Lpath, Inc. (LPTN)

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Last Post: 10/21/2016 12:58:36 PM - Followers: 47 - Board type: Free - Posts Today: 0

Lpath Inc.

Lpath Incorporated
4025 Sorrento Valley Blvd.
San Diego, CA 92121
Tel: 858-678-0800
FAX: 858-678-0900

Lpath, Inc. is a biotechnology company focused on the discovery and development of monoclonal antibodies targeted to bioactive lipids. Lipid-based therapeutics are an emerging field of medical science whereby bioactive signaling lipids are targeted for treating important human diseases that currently lack innovative and effective medicines.

Lpath's ImmuneY2 platform contains the ability to generate therapeutic antibodies that bind to and inhibit bioactive lipids that contribute to the spreading and growth of various diseases and inflammatory/auto-immune disorders.


Lpath, Inc. focuses on the discovery and development of monoclonal antibodies that target bioactive lipids. Numerous lipids that contribute to disease have now been identified through the various efforts of academics and industry. However, the challenge becomes one of generating a compound that neutralizes the relevant bioactive lipid. With its ImmuneY2™ platform technology and robust patent estate, Lpath is uniquely positioned to meet such challenges and exploit these opportunities.

Lpath has leveraged ImmuneY2 and generated monoclonal antibody drug candidates against several bioactive lipids, including sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA), leukotrienes (LTs) and others.

Lpath is currently advancing LpathomabTM, a monoclonal antibody against lysophosphatidic acid (LPA), a key bioactive lipid that has been recognized to be involved in disorders of the central nervous system (including pain, traumatic brain injury, neurodegeneration), fibrosis, ocular disease and cancer. Lpathomab has demonstrated strong preclinical activity in several animal models of these diseases, including neuropathic pain, diabetic neuropathy, traumatic brain injury and spinal cord injury. Lpathomab is currently in a phase 1 clinical trial.

The company is applying ImmuneY2 to other bioactive lipid targets, many of which are involved in important disease processes (e.g. inflammation, cancer, pain, asthma, and others) thereby adding to our pipeline of novel antibody-based drug candidates.

Lpath has a broad and deep intellectual property position in the bioactive lipid area, with over 50 issued or pending patents in the U.S., with corresponding international applications. Most of these patents were developed in-house using our proprietary technologies and expertise.

Executive Team

Gary Atkinson - Chief Executive Officer, Chief Financial Officer

Background: Mr. Atkinson has more than 20 years of financial management experience. Prior to joining Lpath, he served as the Chief Financial Officer for three private life science companies. In addition, Mr. Atkinson was the Vice President of Finance at Isis Pharmaceuticals, a publicly held pharmaceutical research and development company. He began his career with Ernst & Young, where he earned his CPA designation. Mr. Atkinson is a graduate of Brigham Young University.

Dario A. Paggiarino, M.D. - Sr. Vice President & Chief Development Officer

Background: Dr. Paggiarino brings to Lpath more than 25 years of experience in the pharmaceutical industry, having directed global development programs in a number of therapeutic areas including ophthalmology, pain, inflammatory conditions, and oncology. Most recently, Dr. Paggiarino served as Vice President and Therapeutic Unit Head for retina diseases at Alcon, a division of Novartis. He also served as Executive Director of Clinical Development and Medical Affairs at Pfizer Global R&D with focus on global clinical development in glaucoma, diabetic and degenerative retinal diseases, and medical responsibilities for Macugen(R). Earlier in his career, he held R&D positions of increasing responsibility at Angelini Pharmaceuticals, a privately owned company, ultimately serving as president. Later he joined Pharmacia Global R&D where he was clinical program director of ophthalmology with responsibilities for Xalatan(R), the leading glaucoma therapy in the world, and ocular devices such as viscoelastics (Healon(R)) and intraocular lenses (CeeOn(R), Tecnis(R)). Dr. Paggiarino earned his degree in Medicine and General Surgery at the University of Rome La Sapienza and has authored numerous scientific articles.

Gary Woodnutt, Ph.D. - Sr. Vice President & Chief Scientific Officer

Background: Dr. Woodnutt brings to Lpath extensive experience in drug discovery and pharmaceutical research. Prior to joining Lpath, Dr. Woodnutt served as the Vice President, Open Innovation at Pfizer/CovX, but his primary role at CovX, from 2006 to 2012, was as Vice President of Biology Research. From 2002 to 2006, Dr. Woodnutt was the Senior Vice President of Pharmaceutical Research and Development for Diversa Corporation. He began his career in the pharmaceutical industry with Glaxo SmithKline Pharmaceuticals, where he was employed for more than 20 years and rose to the position of Vice President and Head of Biology in the Antimicrobial and Host Defense Group. Dr. Woodnutt received his Ph.D. in biochemistry/physiology from the University of Reading, and he has authored numerous scientific articles.

Roger Sabbadini, Ph.D. - Vice President, Scientific Founder

Background: Dr. Sabbadini was a Professor of Biology for 32 years at San Diego State University and is currently a Professor Emeritus of Biology. He founded three biotechnology companies, including Lpath, that were incubated out of SDSU. Dr. Sabbadini has been interested in the role of bioactive lipids in  various diseases, including cancer, ocular disorders, neurotrauma, neuropathic pain, inflammation and heart disease. Dr. Sabbadini’s research focused on developing novel antibody-based therapeutics against bioactive lipids such as S1P  and LPA and these antibodies have been advanced into human clinical trials. Dr. Sabbadini earned his Ph.D. at the University of California, Davis.

Leigh Hsu, Ph.D., M.B.A. - Vice President, Corporate Development & Strategy

Background: Dr. Hsu has more than 15 years of business experience in the biotech industry. Prior to Lpath, he held positions of increasing responsibility at ACADIA Pharmaceuticals and Collateral Therapeutics (which became a subsidiary of Schering AG, now Bayer). Dr. Hsu played a key role in Lpath's $517 million licensing deal with Pfizer for iSONEP™, and has extensive deal experience with organizations like Wyeth and GE Healthcare, as well as with several academic and research organizations, including the University of California, the University of Texas, Southwestern Medical Center and the Veterans Medical Research Foundation. He has published numerous scientific papers, primarily in the area of the molecular basis of neurodegenerative diseases. Dr. Hsu received his Ph.D. in Molecular Pathology from the University of California, San Diego, and his M.B.A. from the University of California, Irvine.

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Current Price
Bid Ask Day's Range
#709   I have no malicious intent whatsoever, I am KantKill 10/18/16 04:16:20 PM
#707   Things may not be all bad, some of KantKill 10/11/16 07:29:20 PM
#706   The S4 is bad news for LPTN shareholders --- KantKill 10/11/16 06:30:49 PM
#705   fast and steady profit scan LPTN bullish 3.2801 stocktrademan 09/30/16 04:33:10 PM
#704   LPTN $247 merger agreement with Apollo Endo ClearlyStocks 09/08/16 04:07:29 PM
#703   LPTN bullish 2.35 stocktrademan 09/05/16 04:22:42 PM
#702   Target 5.88 Shaka_Zulu 08/22/16 04:16:15 PM
#701   Intersting BillBadaass 08/22/16 01:12:28 PM
#700   LPTN placed on Reg Sho list over 3 Stockexpertpro 08/22/16 09:22:16 AM
#699   * * $LPTN Video Chart 08-19-16 * * ClayTrader 08/19/16 04:53:45 PM
#698   Picked some up at 3.18. Love4Money 08/19/16 12:17:35 PM
#697   Craziness continues ClearlyStocks 08/19/16 12:07:42 PM
#696   Popping Shaka_Zulu 08/17/16 12:33:37 PM
#695   Did you pick up shares today? Betchips 08/17/16 10:37:03 AM
#694   LPTN looking for strategic merger or buyout currently, Betchips 08/17/16 12:34:20 AM
#693   LOL, LPTN is up 0.01 today! The BV Value_Investor 08/05/16 04:16:33 PM
#692   LPTN just hit $2.65! How could it crash Value_Investor 08/04/16 10:22:42 AM
#691   LPTN just hit $2.17! $2.65 should be tested Value_Investor 08/03/16 02:47:53 PM
#690   LOL, I even doubt if LPTN ever hit Value_Investor 08/03/16 11:58:56 AM
#689   How could LPTN drop from $2.65 to $1.81 Value_Investor 08/02/16 10:02:50 AM
#688   LOL, LPTN has $3.71 per share Huge Positive Value_Investor 08/01/16 02:15:22 PM
#687   How could the MMs manipulate LPTN down to Value_Investor 07/29/16 02:27:31 PM
#686   LPTN is Hyper Undervalued now --- Debt-Free plus Value_Investor 07/28/16 11:58:16 AM
#685   LPTN had 39,600 shares shorted in the current month. Value_Investor 07/25/16 01:49:55 PM
#684   LPTN had 25,700 shares shorted in the prior month. Value_Investor 07/25/16 01:48:16 PM
#683   Not many shares were shorted as of 06/30/2016! Value_Investor 07/24/16 05:06:03 PM
#682   LOL, the sick MM manipulated the price down Value_Investor 07/22/16 03:24:00 PM
#681   LPTN Warning Shorting Low Float Bio Tech Stocks Stockexpertpro 07/22/16 01:09:17 PM
#680   LPTN should close above $2.3 today since the Value_Investor 07/22/16 12:04:13 PM
#679   Wow, LPTN exploded to $2.65 today! It will Value_Investor 07/22/16 11:54:07 AM
#678   Crazy low $5.1M market cap!! Insane! tob999 07/22/16 11:13:57 AM
#677   A close above 2.20 will be nice. Bullish Shaka_Zulu 07/22/16 11:04:21 AM
#676   +21% on substantially increased volume! News comin? tob999 07/22/16 10:23:51 AM
#675   Ibox updated and redesigned. tob999 07/22/16 10:23:10 AM
#674   I can smarten up the Ibox if there tob999 07/22/16 09:17:55 AM
#673   Float 2.O3 million !!!!! zino 07/21/16 11:28:10 PM
#672   LPTN has Zero Debt which is a Sought-After Value_Investor 07/21/16 07:14:00 PM
#671   Good timing agreed! Bring on the boom..with this tob999 07/21/16 05:48:36 PM
#670   Nice entry at good timing! The Book Value Value_Investor 07/21/16 12:51:38 PM
#669   Yes. LPTN is Hyper Undervalued now --- $3.71 Value_Investor 07/21/16 12:47:06 PM
#668   bought in this morning...glta zino 07/21/16 12:42:40 PM
#667   can fly here O/S 2,OOO,OOO zino 07/21/16 12:42:24 PM
#666   We all saw that kinds of manipulation efforts Value_Investor 07/20/16 12:39:46 PM
#665   Undervalued indeed. tob999 07/20/16 12:34:00 PM
#664   LPTN hit the New high $2.04 so far! Value_Investor 07/20/16 12:31:41 PM
#663   Being held down on low volume. Every time tob999 07/20/16 12:31:09 PM
#662   LOL, LPTN has $3.71 Per Share Huge Book Value_Investor 07/19/16 02:53:51 PM
#661   LPTN is up 11.48% in the AH session Value_Investor 07/18/16 07:12:11 PM
#660   Who have kept manipulating LPTN down while it Value_Investor 07/18/16 01:57:57 PM
#659   LPTN has measly 2.36M shares Hyper Tiny OS Value_Investor 07/17/16 01:05:31 PM