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Last Post: 10/25/2016 4:09:20 PM - Followers: 78 - Board type: Free - Posts Today: 0

Non-Muscle invasive Bladder Cancer ("NMIBC")

Heat Biologics has developed an ImPACT-based treatment for patients with NMIBC.  Similar to HS-110, HS-410 was designed based on knowledge of the various antigens that are known to be shared amongst a high proportion of patients with bladder cancer. Heat is currently conducting a Phase 2 trial using HS-410 for the treatment of NMIBC. This trial is being performed either in combination with the standard of care, BCG therapy, or alone. Heat believes that BCG is likely to synergize with HS-410 due to the activity of BCG to promote trafficking of HS-410 activated cytotoxic T cells into the bladder endothelium. On the other hand, monotherapy HS-410 has significant patient administration advantages by avoiding intravesical delivery, thus evaluation of its single-agent activity is warranted.

For more information please reference study protocol NCT02010203 on

About Non-Muscle Invasive Bladder Cancer

In 2015, the American Cancer Society estimated 74,000 new cases of bladder cancer will be diagnosed in the U.S. and an estimated 16,000 deaths will occur. More than 500,000 people in the U.S. have been treated for bladder cancer and 70% of those patients have non-muscle invasive bladder cancer.  Importantly, the U.S. Food and Drug Administration has not approved any new drugs to treat bladder cancer in more than 25 years. Heat's HS-410 represents a viable opportunity to address a significant unmet medical need.


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HTBX News: Heat Biologics and University of Miami Announce Zika Vaccine Collaboration 10/25/2016 07:00:00 AM
HTBX News: Heat Biologics to Present at Two Upcoming Investor Conferences and Panel Discussion 10/17/2016 07:30:00 AM
HTBX News: Heat Biologics Remains on Track to Achieve  Multiple Topline Data Readouts this Quarter 10/13/2016 07:00:00 AM
HTBX News: Heat Biologics Selects Adaptive Biotechnologies to Discover Potential Clinical Biomarkers to Advance Novel Immunotherapies 10/11/2016 07:30:00 AM
HTBX News: Prospectus Filed Pursuant to Rule 424(b)(3) (424b3) 10/11/2016 06:05:44 AM
#1154   Just would like to see them let it Ruffieruff 10/25/16 04:09:20 PM
#1153   Fully diluted OS is ~27M per Jeff on Titan V 10/25/16 04:05:13 PM
#1152   Great news but there has to be dilution Ruffieruff 10/25/16 03:59:54 PM
#1151   Yes the two companies technologies complement each other. dia76ca 10/25/16 03:09:20 PM
#1150   That's what ONCS is doing with HTBX: ONCS jboatswain 10/25/16 02:53:16 PM
#1149   Heat's technology can be combined with other drugs dia76ca 10/25/16 11:01:55 AM
#1148   This could be huge! Now, they need to Golf4Food 10/25/16 09:43:23 AM
#1147   Heat Biologics and University of Miami Announce Zika Titan V 10/25/16 09:24:29 AM
#1146   Great Post! If we trade sideways for a Golf4Food 10/23/16 01:12:24 PM
#1145   I don't think HTBX has toxic warrant holders. jboatswain 10/21/16 05:38:07 PM
#1144   All governments, in all parts of the world, dia76ca 10/21/16 01:03:40 PM
#1143   Might take a couple days of pressure to Golf4Food 10/21/16 09:58:13 AM
#1142   Huge wall at 1.24. 105,000 on ask. New Ruffieruff 10/21/16 09:39:50 AM
#1141   The interesting thing about CEO Wolf's words is dia76ca 10/20/16 11:33:44 PM
#1140   Could explain the 20,000 shares bought at 1.20 November61 10/20/16 12:27:04 PM
#1139   CEO Wolf ended todays presentation with these words! dia76ca 10/20/16 12:17:04 PM
#1138   Just about there ;-) Golf4Food 10/19/16 11:28:12 PM
#1137   gp96.....the immune systems Swiss army knife! Interesting article. dia76ca 10/19/16 09:04:50 PM
#1136   Taylor Schreiber's Interview with Cell and Gene Therapy Titan V 10/19/16 07:12:39 PM
#1135   If they present at a conference, it will Titan V 10/18/16 03:02:31 PM
#1134   They're presenting today and on 20th and later Rogerthat1 10/18/16 02:48:56 PM
#1133   Thanks. I read through PRs but couldn't find Rogerthat1 10/18/16 02:48:38 PM
#1132   Biocom webcast link Titan V 10/18/16 02:46:39 PM
#1131   No idea. I emailed IR last week if Titan V 10/18/16 02:40:02 PM
#1130   Do you know when within this quarter will Rogerthat1 10/18/16 02:35:12 PM
#1129   And the slow bleed continues here. What's up Rogerthat1 10/18/16 02:23:41 PM
#1128   #HTBX with an upgraded rating today moneybro2 10/18/16 02:03:31 PM
#1127   I am fully loaded here. Ruffieruff 10/17/16 10:18:58 AM
#1126   Relax. IBB & XBI down. Buy the dips. mh1156 10/17/16 10:17:50 AM
#1125   Relentless selling pressure. How many more warrants do Ruffieruff 10/17/16 10:14:37 AM
#1124* pix 10/17/16 07:51:36 AM
#1123   This is what it is all about! dia76ca 10/15/16 11:39:39 AM
#1122   BMS also uses Adaptive Biotechnologies...they are first rate. dia76ca 10/15/16 11:35:24 AM
#1121   It is good to have this strong statement. dia76ca 10/13/16 10:52:10 AM
#1120   Heat Biologics Remains on Track to Achieve Titan V 10/13/16 08:28:04 AM
#1119   What about SP*S, IP*I ? b/o too and marina22 10/13/16 01:18:32 AM
#1118   Don't know, yet. IMHO, they have the deepest docoroc2 10/12/16 08:03:14 PM
#1117   I think so too. It should have started serious38 10/11/16 12:24:38 PM
#1116   Results to date have been excellent...but this new dia76ca 10/11/16 11:12:45 AM
#1115   Heat Biologics Selects Adaptive Biotechnologies to Discover Potential dia76ca 10/11/16 11:05:54 AM
#1114   I agree. That's why if your a holder Ruffieruff 10/10/16 11:18:00 AM
#1113   Yes, but volume very low for this kind docoroc2 10/10/16 11:16:43 AM
#1112   Pure dumping right now. Until warrant holders have Ruffieruff 10/10/16 10:36:41 AM
#1111   Merck ,Roche, BMY, ...and every other BP need dia76ca 10/09/16 11:32:57 AM
#1110   Bristol's Opdivo Disappoints in Lung Cancer, Losing Ground Titan V 10/09/16 11:16:33 AM
#1109   Manipulation: VWAP: 1.245 Total Vol: 1M jboatswain 10/09/16 12:07:50 AM
#1108   Yes, very much looking forward to phase 2 Titan V 10/08/16 05:03:03 PM
#1107   Heat's phase 1 results are encouraging! dia76ca 10/08/16 03:53:45 PM
#1106   Merck, Roche and Bristol-Myers would all be interested Titan V 10/08/16 03:09:01 PM
#1105   Those are very interesting results for both Merck dia76ca 10/08/16 01:17:50 PM