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Epizyme, Inc. (EPZM)

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Last Post: 9/15/2016 11:01:30 AM - Followers: 12 - Board type: Free - Posts Today: 0
http://www.epizyme.com

Overview & History
Epizyme is a clinical stage biopharmaceutical company that discovers, develops and plans to commercialize innovative personalized therapeutics for patients with genetically defined cancers. We systematically identify the genetic alterations that create cancer causing genes, called oncogenes, select patients in whom the identified genetic alteration is found and then design small molecule therapeutics to inhibit the oncogene. The clinical development plan for each of our product candidates is directed towards patients with a particular genetically defined cancer. Our approach is part of a broader trend towards personalized therapeutics based on first identifying the underlying cause of a disease affecting specific patient populations, applying rational drug design tools to create a therapeutic to bind with a molecular target in the identified disease pathway and using a companion diagnostic to select the right patients for treatment.

We have built a proprietary product platform that we use to create small molecule inhibitors of a 96-member class of enzymes known as histone methyltransferases, or HMTs. Genetic alterations can result in changes to the activity of HMTs, making them oncogenic. When Epizyme was founded, we recognized that the HMT class of enzymes might contain many potential oncogenes and, therefore, presented the opportunity to discover, develop and commercialize multiple personalized therapeutics.

We have prioritized 20 HMTs as attractive targets for personalized therapeutics based on their oncogenic potential. Our two most advanced therapeutic product programs target the HMTs DOT1L (for the treatment of mixed lineage leukemia, or MLL-r) and EZH2 (for a genetically defined subtype of non-Hodgkin lymphoma). We believe that our ongoing Phase 1 study for EPZ-5676, targeting DOT1L, is the first clinical trial of an HMT inhibitor. We expect to initiate a Phase 1/2 clinical trial of EPZ-6438 targeting EZH2 in 2Q 2013.

We were founded in 2007 and are led by a management team with extensive experience in the pharmaceutical industry. We have entered into therapeutic collaborations with Celgene, Eisai and Glaxo Group Limited (an affiliate of GlaxoSmithKline), or GSK, that have provided us with approximately $120 million in non-equity funding through March 31, 2013. As of March 31, 2012, we had $85 million in cash and cash equivalents.
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EPZM News: Current Report Filing (8-k) 11/28/2016 08:55:22 AM
EPZM News: Epizyme Announces Fast Track Designation for Tazemetostat in DLBCL and Provides Solid Tumor Program Update 11/28/2016 06:30:00 AM
EPZM News: Epizyme President of Research and Chief Scientific Officer Named AAAS Fellow 11/21/2016 11:00:00 AM
EPZM News: Quarterly Report (10-q) 11/03/2016 06:45:27 AM
EPZM News: Current Report Filing (8-k) 11/03/2016 06:40:59 AM
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#70   Nice EPZM mention here floWteiuQ 09/15/16 11:01:30 AM
#69   Looks pretty good over here, may have to Kcricket 09/12/16 08:01:19 PM
#68   You bet your bippy it is! floWteiuQ 08/13/16 11:50:21 AM
#67   Is the Epizyme Dip A Discount Entry Opportunity? trendmkr 08/09/16 02:43:08 PM
#66   EPZM-Looking to make some traction today.. BettingAngles 07/18/16 12:08:47 PM
#65   EPZM-Bouncing BettingAngles 07/15/16 12:01:02 PM
#64   by who? What do you guys think the MakinBank 05/23/16 04:47:51 PM
#63   I think their technology looks promising; therefore, I'm floWteiuQ 05/16/16 12:17:33 PM
#62   Price target $32.14! fl89808 02/04/16 11:04:40 AM
#61   Watching EPZM. 60% of the float is short, sumotrader 01/14/16 01:57:54 AM
#60   Year of Biotech's 2016.. BettingAngles 01/11/16 08:11:10 AM
#59   http://www.intercooleronline.com/stocks/zacks-investment-research-upgrades-epizy BettingAngles 01/10/16 09:54:35 AM
#58   BOUNCE TIME-Part II.. BettingAngles 01/08/16 09:22:04 AM
#57   BOUNCE TIME.. BettingAngles 01/07/16 09:18:43 AM
#56   $EPZM recent news/filings stocktrademan 07/01/15 11:36:30 AM
#55   The dumping has begun investorsito 06/22/15 02:19:00 PM
#54   Major correction coming. Shorts will make a killing here investorsito 06/22/15 01:13:18 PM
#53   I'm honestly liking this chart, new here, just snagem83 05/31/15 08:16:20 PM
#52   Wedbush Reiterates Buy On Epizyme Following 2Q14 Update maytepper 08/18/14 04:03:41 PM
#51   $EPZM recent news/filings stocktrademan 08/15/14 11:48:23 AM
#50   $EPZM Cowen Maintains Buy On Epizyme Following 2Q14 maytepper 08/13/14 01:21:22 PM
#49   34 02opida 08/13/14 11:39:57 AM
#48   sounds good 02opida 08/08/14 02:56:02 PM
#47   33 02opida 08/08/14 02:55:38 PM
#46   Science looks pretty good here. Thinking we murocman 08/01/14 09:24:24 AM
#45   33 02opida 07/23/14 04:08:06 PM
#44   31 02opida 07/23/14 09:59:55 AM
#43   28.60 02opida 07/21/14 11:54:03 AM
#42   http://www.epizyme.com/wp-content/uploads/2014/06/Epizyme-ASH-Lymphoma-Release-6 02opida 07/17/14 10:02:03 AM
#41   UPDATE: H.C. Wainwright & Co. Initiates Coverage On 02opida 07/15/14 12:59:58 PM
#40   34 02opida 07/03/14 01:04:45 PM
#39   Epzm crushing it!! collhayyn_ 07/03/14 11:44:54 AM
#38   31 02opida 07/02/14 01:06:09 PM
#37   next two weeks EPZM will be on the 02opida 06/20/14 03:47:56 PM
#36   29 02opida 06/18/14 01:24:35 PM
#35   Epizyme to Give Oral Presentation on Pre-Clinical Models 02opida 06/10/14 09:43:31 AM
#34   CAMBRIDGE, Mass., May 7, 2014 /PRNewswire/ -- 02opida 05/13/14 09:24:52 AM
#33   A good article on SA for Epizyme! Enjoy Inoviorulez 03/25/14 05:25:37 PM
#32   Lol highstakes 01/07/14 09:34:39 AM
#31   Low 20's hanging on tight for the time etradeedge 11/23/13 08:18:49 PM
#30   Grabbed a few more shares at $19. ok, ottoman 11/19/13 03:51:20 PM
#29   "Epizyme Major Shareholder Buys $7,999,920 in Stock (EPZM)" ottoman 11/18/13 07:55:00 PM
#28   I suppose since the Nasdaq got whacked end ottoman 11/18/13 07:45:36 PM
#27   Took a position at 20$.... bra1loga 11/18/13 10:45:55 AM
#26   I'm averaged in at $21 and waiting for Tinkerer 11/18/13 07:58:14 AM
#25   EPZM: "Epizyme Shares Crater - Present Buying Opportunity" ottoman 11/18/13 06:50:10 AM
#24   Epizyme Stock Rating Reaffirmed by Citigroup Inc. (EPZM) ottoman 11/15/13 11:20:15 AM
#23   Patience...it will bounce higher. They are shaking Tinkerer 11/15/13 11:01:19 AM
#22   Ruttt rohhhh! Juschilln 11/15/13 10:29:11 AM
#21   Not looking good here. BOUNCE you POS!!! ottoman 11/15/13 10:18:31 AM
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