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Aeolus Pharmaceuticals (AOLS)

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Last Post: 6/14/2017 10:47:44 AM - Followers: 15 - Board type: Free - Posts Today: 0



Our strategy is to use non-dilutive capital wherever possible to develop our exciting platform of broad-spectrum catalytic antioxidant compounds in important unmet indications of national strategic importance.  We plan to continue to leverage that capital, like the investment made by U.S. government agencies, such as NIH-NIAID and NIH CounterACT, in AEOL 10150 as a medical countermeasure, to concurrently develop these promising compounds for use in significant unmet medical indications, like oncology. We are currently doing this with AEOL 10150, where we are leveraging the potential substantial government investment in research and development of AEOL 10150 as a medical countermeasure to develop the compound in oncology indications, where it would be used in combination with radiation therapy

Business Overview

 We are developing a platform of a new class of broad-spectrum catalytic antioxidant compounds based on technology discovered at Duke University and National Jewish Health. These compounds, known as metalloporphyrins, scavenge reactive oxygen species ("ROS") at the cellular level, mimicking the effect of the body's own natural antioxidant enzyme superoxide dismutase ("SOD").  While the benefits of antioxidants in reducing oxidative stress are well-known, research with our compounds indicates that metalloporphyrins can be used to affect signaling via ROS at the cellular level.  In addition, there is evidence that high-levels of ROS can affect gene expression and this may be modulated through the use of metalloporphyrins. We believe this could have a profound beneficial impact on people who have been exposed, or are about to be exposed, to high-doses of radiation.

Our lead compound, AEOL 10150, is a metalloporphyrin specifically designed to neutralize reactive oxygen and nitrogen species. The neutralization of these species reduces oxidative stress, inflammation, and subsequent tissue damage-signaling cascades resulting from radiation exposure.  We are leveraging the significant investment made by U.S. government agencies to develop this promising compound for use in oncology indications, where it would be used in combination with radiation therapy, and is currently in development for use as both a therapeutic and prophylactic drug. 

AEOL 10150 has previously been tested in two Phase I clinical trials with no serious adverse events reported.  Data have already been published showing that AEOL 10150 does not interfere with the therapeutic benefit of radiation therapy in prostate and lung cancer preclinical studies.  Early next year we expect to release data showing the drug's impact, if any, when used in combination with radiation and/or chemotherapy.  In mid-2011 we expect to begin Phase I/II studies in non-small cell lung cancer ("NSCLC").

AEOL 10150 is also being developed as a medical countermeasure against the pulmonary sub-syndrome of acute radiation syndrome ("Pulmonary Acute Radiation Syndrome" or "Lung-ARS") as well as the gastrointestinal sub-syndrome of acute radiation syndrome ("GI-ARS"), both caused by exposure to high levels of radiation due to a radiological or nuclear event.  It is also being developed for use as a countermeasure for exposure to chemical vesicants such as chlorine gas and sulfur mustard gas.  AEOL 10150 has already performed well in animal efficacy and safety studies in each of these potential indications.  A significant portion of the funding for the medical countermeasure development programs to date has come from various government entities.    Although our management expects this funding to continue, there is no guarantee that it will do so.  We have submitted proposals to the Biomedical Advanced Research and Development Authority ("BARDA") to develop AEOL 10150 as countermeasures for both Lung-ARS and cholorine gas exposure.  We are awaiting a final decision from BARDA on the contract.  If the contract from BARDA is awarded, it is expected that it will fund all of the costs to bring AEOL 10150 to FDA approval for that indication.

We have two programs underway for the development of our second drug candidate, AEOL 11207, for the treatment of epilepsy and Parkinson's disease.   These programs are being funded, in part, by private foundations and government grants.


 PDF Presentation Feb 2011:



Share Structure:

60,470,718 outstanding shares as of  MAY 10,2011
200,000,000 shares authorized

~ 6 - 9 Million shares in the Float
as of Jan 26, 2011



Point of Contact:

CFO: Russell Skibsted

Public Company, Headquarters Location
26361 Crown Valley Pkwy., Ste. 150, Mission Viejo, CA 92691-7324, United States
(949)481-9825, (949)481-9829 fax

AOLS (Daily)

AOLS (Weekly)


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AOLS News: Quarterly Report (10-q) 05/15/2017 05:59:03 PM
AOLS News: Current Report Filing (8-k) 03/24/2017 11:51:26 AM
AOLS News: Quarterly Report (10-q) 02/17/2017 04:04:16 PM
AOLS News: Notification That Quarterly Report Will Be Submitted Late (nt 10-q) 02/14/2017 11:17:47 AM
AOLS News: Amended Annual Report (10-k/a) 01/30/2017 05:06:26 PM
#437   Anyone here ask few ? MADDSTACKER 06/14/17 10:47:44 AM
#436   Crazy ...this should went way higher ... MADDSTACKER 06/09/17 12:00:10 PM
#435   Was out of pocket all day. I am Sheep 06/08/17 07:40:55 PM
#434   This test is being funded by us government MADDSTACKER 06/08/17 03:05:08 PM
#433   Looks like dilutor so are gone !! MADDSTACKER 06/08/17 01:32:26 PM
#432   I'm also holding long for the gap fill LtRyan 06/08/17 12:19:56 PM
#431   Should work its way back up IMHO look MADDSTACKER 06/08/17 11:44:18 AM
#430   Well...that was anticlimactic! LtRyan 06/08/17 11:08:06 AM
#429   Says only product in market like this .... MADDSTACKER 06/08/17 10:47:19 AM
#428   FDA fast track news: FDA fast track designation LtRyan 06/08/17 10:46:10 AM
#427   Fast track !!!!! MADDSTACKER 06/08/17 10:45:37 AM
#426   Wow someone stepping out the last few days. Sheep 05/31/17 09:47:41 AM
#425   Now this is positive news: Sheep 05/16/17 09:52:20 AM
#424   AOLS News: Current Report Filing (8-k) 03/24/2017 11:51:26 AM mick 05/14/17 11:47:32 AM
#423   Aeolus Pharmaceutica (AOLS) mick 05/14/17 11:47:26 AM
#422   CSTI just sucks up sells on the bid. jimbob4stocks 05/08/17 03:11:35 PM
#421   I wondered the same thing. I wonder if Sheep 04/28/17 04:23:20 PM
#420   Big move coming Monday! jimbob4stocks 04/28/17 04:22:16 PM
#419   Nice hit at the ask. Now we just Sheep 04/28/17 03:52:49 PM
#418   Great article! This reminds me of those jimbob4stocks 04/12/17 08:53:52 AM
#417   Wow that is coming directly from Dr. Rick Sheep 04/11/17 04:01:51 PM
#416   Aols is mentioned in this Bloomberg article today: SF Wolf 04/11/17 09:25:53 AM
#415   Aeolus Pharmaceutica (AOLS) mick 04/08/17 12:02:08 PM
#414   Morning $AOLS Rogue Dead Guy 04/05/17 06:23:45 AM
#413 All the investor stuff you need jimbob4stocks 04/04/17 01:13:53 PM
#412   I emailed the company to see if they Sheep 04/04/17 09:50:34 AM
#411   Morning $AOLS Rogue Dead Guy 04/04/17 06:37:56 AM
#410   None.. good news would sure help! $AOLS Rogue Dead Guy 04/03/17 10:25:15 PM
#409   No reason it can't get there again jimbob4stocks 04/03/17 10:24:50 PM
#408   .20s would be nice!! $AOLS Rogue Dead Guy 04/03/17 10:24:27 PM
#407   Holding until .20+ but would definitely love some jimbob4stocks 04/03/17 10:23:04 PM
#406   Need some good news to send this flying! Rogue Dead Guy 04/03/17 10:21:59 PM
#405   Hey hey hey jimbob4stocks 04/03/17 10:20:52 PM
#404   Broke .10 and held! $AOLS Rogue Dead Guy 04/03/17 10:20:36 PM
#403   May we see .10 break and hold? Possibly jimbob4stocks 04/03/17 09:13:17 AM
#402   Morning $AOLS Rogue Dead Guy 04/03/17 08:11:45 AM
#401   Maybe dip back down to the .06 area Rogue Dead Guy 04/02/17 05:57:57 PM
#400   Morning $AOLS Rogue Dead Guy 03/31/17 08:30:13 AM
#399   Pretty slow day here.... nice finish though $AOLS^ Rogue Dead Guy 03/30/17 10:57:36 PM
#398   Morning $AOLS Rogue Dead Guy 03/30/17 06:56:19 AM
#397   Someone seriously needs to sell me some .06s Rogue Dead Guy 03/29/17 08:34:54 PM
#396   13's hitting BOOOM! jimbob4stocks 03/29/17 09:32:59 AM
#395   Right there with you jimbob4stocks 03/28/17 11:34:52 AM
#394   Sell me som .06? Daddy needs a new Rogue Dead Guy 03/28/17 09:07:52 AM
#393   Agreed! $AOLS Rogue Dead Guy 03/28/17 08:13:37 AM
#392   I got .085-.09. Nothing wrong with the jimbob4stocks 03/28/17 08:04:18 AM
#391   I picked up .075 last week on the Rogue Dead Guy 03/28/17 08:02:19 AM
#390   Anything under 10 is a deal jimbob4stocks 03/28/17 07:59:42 AM
#389   Looked like it maybe was heading in that Rogue Dead Guy 03/28/17 05:09:50 AM
#388   I had bids at 7 and 8. jimbob4stocks 03/27/17 10:43:24 PM