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Aeolus Pharmaceuticals (AOLS)

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Last Post: 8/11/2017 12:44:30 PM - Followers: 15 - Board type: Free - Posts Today: 0

NASDAQ BB

http://www.aolsrx.com/

Strategy

Our strategy is to use non-dilutive capital wherever possible to develop our exciting platform of broad-spectrum catalytic antioxidant compounds in important unmet indications of national strategic importance.  We plan to continue to leverage that capital, like the investment made by U.S. government agencies, such as NIH-NIAID and NIH CounterACT, in AEOL 10150 as a medical countermeasure, to concurrently develop these promising compounds for use in significant unmet medical indications, like oncology. We are currently doing this with AEOL 10150, where we are leveraging the potential substantial government investment in research and development of AEOL 10150 as a medical countermeasure to develop the compound in oncology indications, where it would be used in combination with radiation therapy

Business Overview

 We are developing a platform of a new class of broad-spectrum catalytic antioxidant compounds based on technology discovered at Duke University and National Jewish Health. These compounds, known as metalloporphyrins, scavenge reactive oxygen species ("ROS") at the cellular level, mimicking the effect of the body's own natural antioxidant enzyme superoxide dismutase ("SOD").  While the benefits of antioxidants in reducing oxidative stress are well-known, research with our compounds indicates that metalloporphyrins can be used to affect signaling via ROS at the cellular level.  In addition, there is evidence that high-levels of ROS can affect gene expression and this may be modulated through the use of metalloporphyrins. We believe this could have a profound beneficial impact on people who have been exposed, or are about to be exposed, to high-doses of radiation.

Our lead compound, AEOL 10150, is a metalloporphyrin specifically designed to neutralize reactive oxygen and nitrogen species. The neutralization of these species reduces oxidative stress, inflammation, and subsequent tissue damage-signaling cascades resulting from radiation exposure.  We are leveraging the significant investment made by U.S. government agencies to develop this promising compound for use in oncology indications, where it would be used in combination with radiation therapy, and is currently in development for use as both a therapeutic and prophylactic drug. 

AEOL 10150 has previously been tested in two Phase I clinical trials with no serious adverse events reported.  Data have already been published showing that AEOL 10150 does not interfere with the therapeutic benefit of radiation therapy in prostate and lung cancer preclinical studies.  Early next year we expect to release data showing the drug's impact, if any, when used in combination with radiation and/or chemotherapy.  In mid-2011 we expect to begin Phase I/II studies in non-small cell lung cancer ("NSCLC").

AEOL 10150 is also being developed as a medical countermeasure against the pulmonary sub-syndrome of acute radiation syndrome ("Pulmonary Acute Radiation Syndrome" or "Lung-ARS") as well as the gastrointestinal sub-syndrome of acute radiation syndrome ("GI-ARS"), both caused by exposure to high levels of radiation due to a radiological or nuclear event.  It is also being developed for use as a countermeasure for exposure to chemical vesicants such as chlorine gas and sulfur mustard gas.  AEOL 10150 has already performed well in animal efficacy and safety studies in each of these potential indications.  A significant portion of the funding for the medical countermeasure development programs to date has come from various government entities.    Although our management expects this funding to continue, there is no guarantee that it will do so.  We have submitted proposals to the Biomedical Advanced Research and Development Authority ("BARDA") to develop AEOL 10150 as countermeasures for both Lung-ARS and cholorine gas exposure.  We are awaiting a final decision from BARDA on the contract.  If the contract from BARDA is awarded, it is expected that it will fund all of the costs to bring AEOL 10150 to FDA approval for that indication.

We have two programs underway for the development of our second drug candidate, AEOL 11207, for the treatment of epilepsy and Parkinson's disease.   These programs are being funded, in part, by private foundations and government grants.

 

 PDF Presentation Feb 2011:  www.aeoluspharma.com/wp-content/uploads/2010/10/Aeolus-Presentation-January-2011_Web.pdf

 

 

Share Structure:

60,470,718 outstanding shares as of  MAY 10,2011
200,000,000 shares authorized

~ 6 - 9 Million shares in the Float
as of Jan 26, 2011

 

 

Point of Contact:

CFO: Russell Skibsted

Public Company, Headquarters Location
26361 Crown Valley Pkwy., Ste. 150, Mission Viejo, CA 92691-7324, United States
(949)481-9825, (949)481-9829 fax

















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AOLS News: Quarterly Report (10-q) 08/14/2017 05:09:19 PM
AOLS News: Quarterly Report (10-q) 05/15/2017 05:59:03 PM
AOLS News: Current Report Filing (8-k) 03/24/2017 11:51:26 AM
PostSubject
#478   Looking thin today MADDSTACKER 08/11/17 12:44:30 PM
#477   Sounds good :) MADDSTACKER 08/10/17 01:18:23 PM
#476   BioDefense sector is about to jump. AOLS jimbob4stocks 08/10/17 01:17:45 PM
#475   Ready for bounce , selling needs to stop MADDSTACKER 08/10/17 01:12:42 PM
#474   NEWS AUGUST 1 jimbob4stocks 08/07/17 12:43:34 PM
#473   9's up shortly! Added heavily below 75. jimbob4stocks 08/07/17 12:17:39 PM
#472   100K bid at 75. Might add to jimbob4stocks 08/03/17 02:14:17 PM
#471   Long hold stock simple :) potential is huge MADDSTACKER 08/03/17 02:13:39 PM
#470   $AOLS is a no brainer. Look at jimbob4stocks 08/03/17 02:02:57 PM
#469   Added 20k same as you. Back to lurking!! investorsa 08/03/17 12:14:21 PM
#468   You're right. Spoke with David at the jimbob4stocks 08/03/17 12:04:22 PM
#467   Now that I have reread everything, I don't Sheep 08/03/17 12:01:02 PM
#466   Someone gave me 50K @ .0675. Thank you!!! jimbob4stocks 08/02/17 10:36:36 AM
#465   Amen brother! This is a big pharmaceutical jimbob4stocks 08/01/17 09:37:52 AM
#464   I'm still accumulating amounts here and there as Zlinger 07/31/17 09:21:51 AM
#463   Let's goooooi MADDSTACKER 07/26/17 11:27:15 AM
#462   $AOLS primed. 200K orders around .08. jimbob4stocks 07/26/17 09:40:36 AM
#461   The BARDA Lung ARS contract, awarded in 2011, jimbob4stocks 07/24/17 03:51:38 PM
#460   It's almost August! 60 days is coming jimbob4stocks 07/24/17 08:52:05 AM
#459   I am still holding and adding small chunks Sheep 07/21/17 01:08:03 PM
#458   Look at the AEZS chart and after FDA jimbob4stocks 07/20/17 08:31:43 AM
#457   10 4 sounds great let's hope we get MADDSTACKER 07/19/17 04:49:20 PM
#456   https://www.fda.gov/ForPatients/Approvals/Fast/ucm405399.htm Fast Track desig jimbob4stocks 07/19/17 04:42:12 PM
#455   I read that , I don't see where MADDSTACKER 07/19/17 04:40:41 PM
#454   http://www.marketwired.com/press-release/aeolus-announces-fda-fast-track-designa jimbob4stocks 07/19/17 04:39:58 PM
#453   I see February they started trial 1 , MADDSTACKER 07/19/17 04:38:03 PM
#452   I don't see anything about 60 days MADDSTACKER 07/19/17 04:37:10 PM
#451   Fast track. 60 day trial. Started jimbob4stocks 07/19/17 04:35:29 PM
#450   What trial are they in ? MADDSTACKER 07/19/17 04:33:06 PM
#449   Waiting on FDA news. 5 years of jimbob4stocks 07/19/17 04:29:05 PM
#448   Added some more ready for some updates and MADDSTACKER 07/19/17 04:25:48 PM
#447   Added another 20K @ .0835 jimbob4stocks 07/17/17 02:26:45 PM
#446   Agreed easily ..:) MADDSTACKER 07/17/17 10:01:43 AM
#445   Keep giving me cheapies! When this hits jimbob4stocks 07/14/17 03:29:41 PM
#444   BARDA's decision was heavily because of AOLS not jimbob4stocks 07/12/17 08:34:11 AM
#443   Awesome , I'm holding thank you !! MADDSTACKER 07/11/17 12:37:03 PM
#442   FDA fast track takes 60 days or less. jimbob4stocks 07/11/17 12:35:28 PM
#441   Hi , not sure why we aren't way MADDSTACKER 07/11/17 12:29:52 PM
#440   Accumulating jimbob4stocks 07/10/17 10:09:06 AM
#439   Aeolus Pharmaceutica (AOLS) mick 07/09/17 10:05:19 AM
#438   Goal is 60 days. Should hear back jimbob4stocks 07/07/17 11:00:37 AM
#437   Anyone here ask few ? MADDSTACKER 06/14/17 10:47:44 AM
#436   Crazy ...this should went way higher ... MADDSTACKER 06/09/17 12:00:10 PM
#435   Was out of pocket all day. I am Sheep 06/08/17 07:40:55 PM
#434   This test is being funded by us government MADDSTACKER 06/08/17 03:05:08 PM
#433   Looks like dilutor so are gone !! MADDSTACKER 06/08/17 01:32:26 PM
#432   I'm also holding long for the gap fill LtRyan 06/08/17 12:19:56 PM
#431   Should work its way back up IMHO look MADDSTACKER 06/08/17 11:44:18 AM
#430   Well...that was anticlimactic! LtRyan 06/08/17 11:08:06 AM
#429   Says only product in market like this .... MADDSTACKER 06/08/17 10:47:19 AM
PostSubject