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$KAVL Kaival Brands (NASDAQ:KAVL): Prominent Firm Issues 'Strong Buy' Recommendation
https://www.marketscreener.com/quote/stock/KAIVAL-BRANDS-INNOVATIONS-111314401/news/Kaival-Brands-NASDAQ-KAVL-Prominent-Firm-Issues-Strong-Buy-Recommendation-44279135/
$AURI huge share structure reductions coming
Check it out
https://www.otcmarkets.com/otcapi/company/dns/news/document/67830/content
BIG NEWS FROM LVGI - Limitless Venture Group, Inc. Continues Its Expansion into the $250 Billion Dollar MGU/TPA Industry with A Strategic Partnership | LVGI - Limitless Venture Group Inc. | News | OTC Markets
https://www.otcmarkets.com/stock/LVGI/news/Limitless-Venture-Group-Inc-Continues-Its-Expansion-into-the-250-Billion-Dollar-MGUTPA-Industry-with-A-Strategic-Partner?id=282819
$SCNG News! Strattner Technologies Partners with Pareteum to Launch Mobile Virtual Network Operator
http://www.prnewswire.com/news-releases/strattner-technologies-partners-with-pareteum-to-launch-mobile-virtual-network-operator-301130898.html
SMAA 0002's Hitting & Falling $$$$
https://www.otcmarkets.com/stock/SMAA/security
#FPVD @002 !! DD posted have a look at sticky now.. https://investorshub.advfn.com/boards/read_msg.aspx?message_id=157980322
ENZC 0005's about to be GONE for good ! Over 22 million buy's so far
today !! News at anyday !
PATENT VALUE PROJECTED PATENT VALUATION Predicted Patent Value: $5,203,874.67 https://enzolytics.com/patent
Sports Venues of Florida, Inc., ($BTHR) (“Sports Venues of Florida”, “BTHR”, or the “Company”), an emerging leader in the eSports, youth sports, and family sports entertainment markets, along with its wholly-owned subsidiary, Shadow Gaming, Inc. (“Shadow Gaming”), a rapidly growing force in the global eSports space, announces War Thunder International Tournament August 29-30th.
We are pleased to announce in conjunction with Gaijin the game developer, our first War Thunder tournament with $500 USD prize pool, in-game rewards/cosmetics, and Shadow Credits. The event takes place on August 29th and 30th (Saturday and Sunday), starting at 18:00 UTC with two parts: group stage and playoffs We will be using Gaijin's TSS website; to sign up please go to https://tss.warthunder.com/index.php?action=tournament&id=11717
All participants will receive 100 Shadow Credits to be used at the Shadow Gaming store when it releases. Shoutcasted on https://www.twitch.tv/shadowgamingfps
TSNP someone was loading this up July 9th and 10th.
https://www.stockscores.com/charts/charts/?ticker=Tsnp
https://ih.advfn.com/stock-market/USOTC/tesoro-enterprises-pk-TSNP/historical/more-historical-data
looks like what I saw way back before GOIG ran from 0001 to 0018
Something might be in the works
$MMEX
45M bid
177M on .0002's
Thin considering o/s
Railway under construction
#permianbasin #refinary #oilandgas
$GTEH just interviewed by MoneyTV, the interview can be watched here: https://www.gentechholdings.com/moneytv-interview-08-05-2020/
$ACI Albertsons initiated with a Buy at Citi Citi analyst Paul Lejuez initiated coverage of Albertsons with a Buy rating and $22 price target. The company is "winning in this uncertain environment" and is well positioned to capitalize on eat at home trends, Lejuez tells investors in a research note. Following its initial public offering on June 26, the stock is down 3%, presenting an attractive entry point for a pure play food retailer, says the analyst.
Read more at:
https://thefly.com/landingPageNews.php?id=3128554
$MEDH “The Starbucks of Cannabis”. Only 56m OS! 8-12 franchises already open! Don’t get left out! Parabolic boom incoming!
$$$$$$ M E D H $$$$$$
$ALST RICH TV LIVE | ALLSTAR HEALTH BRANDS (OTC: ALST)
$ALST breaking news https://finance.yahoo.com/news/allstar-health-brands-inc-alst-173500722.html
$SURG is on Twitter: https://www.twitter.com/surgeholdings
#TPAC Annotated Chart / Targets
Targets 0.0008 / 0.0012 / 0.0018 / 0.0028
http://www.allotcbb.com/quote.php?symbol=TPAC
Profile - News - Filings - Short Sales
http://www.otcmarkets.com/stock/TPAC/profile
http://stockcharts.com/h-sc/ui?s=TPAC&p=D&yr=0&mn=3&dy=15&id=p07581492662
http://stockcharts.com/h-sc/ui?s=TPAC&p=D&yr=0&mn=5&dy=15&id=p56852053299
Targets 0.0008 / 0.0012 / 0.0018 / 0.0028
http://www.allotcbb.com/quote.php?symbol=TPAC
http://stockcharts.com/h-sc/ui?s=TPAC&p=D&yr=0&mn=3&dy=15&id=p07581492662&a=409076185&listNum=17
$EVTI Ask very small b4 break at 0002's !
Enzolytics Inc (PK) (ENZC)
0.0005 ? 0.0001 (25.00%)
Volume: 15,734,388 @06/08/20 3:56:49 PM EDT
All American Gold Co (AAGC)
0.0005 ? 0.00015 (42.86%)
Volume: 259,285,047 @
JC Penney Company In (JCPNQ)
0.4475 ? 0.1256 (39.02%)
Volume: 44,386,240
Gulf West Investment (GLFW)
0.0285 ? 0.015 (111.11%)
Volume: 2,447,418 @06/08/20 10:53:59 AM EDT
Bid Ask Day's Range
0.0225 0.0285 0.014 - 0.029
GLFW Detailed Quote
Buscar (PK) Stock Price - CGLD
2
Follow CGLD
0.1099
0.073 (197.8%) Upgrade to Real-Time
Market Open
Company Name Stock Ticker Symbol Market Type
Buscar Company (PK) CGLD OTCMarkets Common Stock
Price Change Change Percent Stock Price Low Price High Price Open Price Close Price Last Traded
0.073 197.8% 0.1099 0.0767 0.18 0.10 0.0369 10:53:58
Bid Price Ask Price Spread Spread % News
0.09 0.1099 0.0199 18.1% 1 -
Stock Trades Traded Volume VWAP Dollar Volume Average Volume 52
SUTI June 4. SutimCo Provides New Business Development and Shareholder Updates.
https://finance.yahoo.com/news/sutimco-provides-business-development-shareholder-124500386.html
$VSYM ARE YOU:
— Duly Diligent Trader ♃ (@DlyDiligentTrdr) June 7, 2020
$GCGX breaking news out this am!
https://ih.advfn.com/stock-market/USOTC/global-consortium-pk-GCGX/stock-news/82446786/global-consortium-inc-s-brand-indulge-oils-starts-rolling-off-the-manufacturing
#RevenueProducerGCGX
Ceo got busted for security fraud
EVTI Easily access your calendar, create events and capture
digital photos and videos the way you want – with total control.
http://www.eventure.com/
$MILV FAQ's great idea!!! Thanks, meanwhile,
$MILV tic toc, 6 trading days left to load before the news and price explosion.
Biotec birth via R/M is confirmed by multiple sources to be in process.
Name already updated to NDT Pharmaceuticals Inc., at the Nevada SOS, telling us the CCA, LLC R/M is a done deal on autopilot.
Court hearing to release the custodian is March 12th.
$MILV here is an early peak at what CCA, who is R/M with $MILV is bringing to the R/M. PR's news, SEC Form 10, 2 websites, 2 years of audited financials by the new auditor 8-K filed with SEC. all in the works. Fast forward to the bottom for the meat folks!!!!
"Every 23 seconds in the United States an individual experiences a traumatic brain injury (TBI), with a fatality occurring once every 7 minutes. TBI touches the lives of an estimated 1.7 million people in the U.S. annually – 52,000 die, 275,000 are hospitalized and 1,365,000, nearly 80%, are treated and released from an emergency department. TBI is a contributing factor to nearly a third (30.5%) of all injury-related deaths in the United States. While these statistics are staggering, the occurrence of traumatic brain injury is likely underestimated and thus has been termed “a silent epidemic.”
Traumatic Brain Injury has become one of the signature injuries of Operation Enduring Freedom and Operation Iraqi Freedom.
According to the Wounded Warriors Project, 320,000 brave men and women who fought gallantly for our nation in the theaters of Iraq and Afghanistan suffered a TBI.
Of all military personnel who experienced injuries because of hostile fire and who were evacuated to Walter Reed Army Medical Center, 28% endured a TBI.
So many of our nation’s heroes have been left with the invisible scars of war; for those who suffered traumatic brain injury, the hidden marks of combat can lead to depression, posttraumatic stress syndrome, and loss of psychosocial skills.
The ubiquitous impacts of traumatic brain injury transcend the arena of combat to the arena of sports. Head impacts and concussions caused by contact sports are a quickly growing epidemic among young athletes. According to reports from the Centers for Disease Control (CDC), the number of reported concussions has doubled in the last ten years.
The American Academy of Pediatrics has reported that emergency room visits for concussions in children ages 8 to 13 years old has doubled, and concussions have risen 200 percent among teens ages 14 to 19 in the last decade. Concussion is simply another name for mild TBI that, left undetected, can result in long-term brain damage and may even prove fatal.
While football tends to dominate discussions concerning TBI and concussions, data from the American Society of Neurological Surgeons suggests riding a bicycle is far more dangerous than hitting the gridiron. Cycling accidents were involved in 86,000 of the 447,000 sports-related head injuries in 2009; football accounted for only 47,000 of those incidents.
Statistics provided by the U.S. Consumer Product Safety Commission (CPSC) reveals the following ten sports/recreational activities contribute to the highest number of head injuries treated in U.S. emergency rooms (ranked in order of highest occurrence and contributory factor):
1. Cycling 2. Football 3. Baseball and Softball 4. Basketball 5. Water Sports (Diving, Scuba Diving, Surfing, Swimming, Water Polo, Water Skiing, Water Tubing) 6. Powered Recreational Vehicles (ATVs, Dune Buggies, Go-Carts, Mini bikes, Off-road) 7. Soccer 8. Skateboards/Scooters 9. Fitness/Exercise Health Club 10. Winter Sports (Skiing, Sledding, Snowboarding, Snowmobiling)
Surprisingly, there are more incidents of treatment for head-injuries sustained while playing golf than competing in hockey, rugby or lacrosse; this demonstrates contact sports are not requisite for TBI.
The CPSC further assorts the top ten head-injury categories among children ages 14 and younger:
1. Cycling 2. Football 3. Baseball and Softball 4. Basketball 5. Skateboards/Scooters 6. Water Sports 7. Soccer 8. Powered Recreational Vehicles 9. Winter Sports 10. Trampolines
In 2002, a rare disease was found in the brain of NFL legend Mike Webster. Nicknamed “Iron Mike” for his legendary toughness, Webster missed only four games over the course of his sixteen year career. Yet his grit could not help him overcome the disease of chronic traumatic encephalopathy (CTE) that was discovered in his brain after his untimely death at age 50. CTE is a progressive degenerative disease of the brain found in people with a history of repetitive brain trauma, including symptomatic concussions as well as subconcussive hits to the head that do not cause symptoms and can manifest into memory loss, impaired judgment, depression, aggression, advanced dementia and in the case of at least eight former football players, suicide.
According to findings published by the Department of Veterans Affairs’ brain repository in Bedford, Massachusetts, the number of cases of chronic traumatic encephalopathy (CTE) has experienced a two-fold increase over the last decade. Researchers there examined the brain tissue of 128 football players who, before their deaths, played the game professionally, semiprofessionally, in college or in high school. Of that sample, 101 players, or just under 80%, tested positive for CTE. The brain bank further examined the brains of 79 deceased NFL players and found evidence of degenerative brain disease in 76 of those players. Recently, the NFL
released estimates that nearly three in ten former players will develop debilitating brain conditions, and that they will be stricken earlier and at least twice as often as the general population. The league expects about 6,000 of the 19,400 retired players, or 28 percent, to develop Alzheimer's disease or at least moderate dementia. Dozens more will be diagnosed with Lou Gehrig's or Parkinson's disease during their lives, according to the data.
The Washington Post, in a February 2015 article, asserts the flood of media attention highlighting damaged brains, dementia and suicides in retired NFL players has made concussions synonymous with football. That attention was greatly needed as the debilitating consequences of brain injuries in football players of all ages has been severely overlooked. But the focus of this controversy has been far too narrow. It is true that young players need better equipment and stricter safety standards on the gridiron. But in many of the most popular sports, boys aren’t the ones most likely to be afflicted by concussions. Girls are.
Recent studies of high school and collegiate athletes have shown that girls and women suffer from concussions at higher rates than boys and men in similar sports — often significantly higher. For instance, in a recent analysis of college athletic injuries, female softball players experienced concussions at double the rate of male baseball players. Women also experienced higher rates of concussions than men in basketball and soccer. Across all sports in the study, the highest rate of concussions was reported not by male football players, but by female ice hockey players. In that sport, a woman experienced a concussion once every 1,100 games or practices, nearly three times the rate experienced in football. The gender disparity exists in high school sports, too. One study, analyzing concussion data for athletes in 25 high schools, found that in soccer, girls experienced concussions at twice the rate of boys.
Whether due to a traumatic brain injury sustained on the battlefield or on the home-front, cognitive impairment is a common consequence of such affliction. Sadly, no United States Food and Drug Administration (FDA) approved treatments for cognitive impairments due to TBI exist. Treatments for posttraumatic cognitive impairments are non-pharmacologic and include education, realistic expectation setting, environmental and lifestyle modifications, and cognitive rehabilitation.
Dietary amino acids, glucagon-like peptides administered in the treatment of Type II Diabetes and even plants used in Chinese and Indian traditional medicine have shown promise in ameliorating injury-induced cognitive damage. Yet their virtue and that of other potentially therapeutic agents (PNA) for cognitive harm and other Central Nervous System (CNS) maladies are impeded by the pathophysiological nature of the Blood-Brain-Barrier (BBB).
More than 100 years ago it was discovered that if blue dye was injected into the bloodstream of an animal, tissues of the whole body EXCEPT the brain and spinal cord would turn blue. To explain this, scientists conceived the notion of a Blood-Brain-Barrier, a biological palisade preventing materials from the blood from entering the brain. More recently, scientists have discovered much more about the structure and function of the BBB.
The BBB is a semi-permeable biological barrier; that is, it allows some materials to cross while preventing others from entering the brain. In most parts of the body, the smallest blood vessels,
called capillaries, are lined with endothelial cells. Endothelial tissue has small spaces between each individual cell so substances can move readily between the inside and outside of the vessel. However, in the brain, the endothelial cells fit tightly together and substances cannot pass out of the bloodstream.
The brain is a highly sensitive and fragile neuronal organ; the Blood-Brain-Barrier ensures it receives its regular supply of fuels, gases, and nutrients essential for maintaining homeostasis and other vital functions while effectively protecting the brain from many common bacterial infections. Yet, this custodial nature of the BBB inhibits delivery of therapeutic agents to the CNS and imposes obstruction for delivery of large numbers of drugs, including antibiotics, antineoplastic agents, and neuropeptides, to pass through the endothelial capillaries to the brain.
The efficacy of a drug designed to mend cognitive damage is predicated upon its successful delivery into the brain and its proper distribution, and while several drug delivery methods and strategies have been developed for injury-induced cognitive impairment and other CNS related disease therapeutics, most of them are proved invasive and lack target specificity. Nanotechnology, more specifically nano-enabled delivery systems, offer a promising solution to improve the uptake and targeted delivery of the drugs into the brain and are proved to be the best method of transferring drugs across the BBB.
Nanoparticles are tiny molecules made up of natural or artificial polymers that interact with and easily traverse biological barriers, allowing for effective drug targeting and bio-distribution of pharmaceuticals in a controlled manner. These tiny particles range in size from between 10 and 100,000 nanometers – To put the size of a nanometer in context, the thickness of a sheet of paper is 100,000 nanometers while the thickness of a strand of human hair is 80,000 nanometers; nanoparticles become invisible to the human eye at 130 nanometers.
Compelling Competitive Advantage, LLC (CCA) owns a versatile and widely applicable biotechnology asset base. Its Nanoscale Particle Complex (NPC) technology represents the leading edge of nano-encapsulation delivery systems (less than 100 nanometers in diameter; mean diameter of 40 nanometers in current liquid product samples with the capability to engineer significantly smaller nano-carrier particles) that create instant delivery of therapeutic payloads into the blood stream, beginning through the membranes of the mouth. This mean diameter of 40 nanometers equates to 40 nanoparticles of therapeutic agents crossing the BBB into blood brain tissue. Small equals fast! This instant delivery aspect functions as an “Oral IV;” providing the patient with instant gratification and effect upon consumption of the product utilizing the NPC delivery mechanism.
While nanoparticles may be composed of natural AND artificial polymers, CCA’s technology is categorized as a food product by the FDA being comprised of lecithin from soy bean sources, water and small amounts of denatured alcohol. As a point of fact, many individuals produce a product with a small component of particles similar in size to the company’s NPC technology everyday – shakes and smoothies. The process of adding soy bean lecithin into water with other food materials and juices followed by subjecting the mixture to a blender or food processor yields a nutritional “drink” containing macro particulates, and even a small amount of nanoparticles. Individuals consuming these drinks have, in fact, been consuming a product
similar to CCA’s without any reported deleterious effects or warnings and regulation by the FDA.
CCA’s organic nanoparticle design is of utmost importance as toxicity is an extremely important factor and limitation of drug delivery studies and a major area of interest in research on nanoparticle delivery to the brain.
Although solid nanoparticles may be used for drug targeting, when reaching the intended diseased site in the body, the drug carried needs to be released. Thus, for drug delivery, biodegradable nanoparticle formulations are needed as it is the intention to transport and release the drug in order to be effective.
However, model studies to the behavior of nanoparticles have largely been conducted with non-degradable particles comprised of nonbiological components such as metals like iron or cadmium.. Most data concerning the biological behavior and toxicity of particles comes from studies on inhaled nanoparticles as part of the unintended release of ultrafine or nanoparticles by combustion derived processes such as diesel exhaust particles. Research has demonstrated that exposure to these combustion derived ultrafine particles/nanoparticles is associated with a wide variety of effects including pulmonary inflammation, immune adjuvant effects and systemic effects including blood coagulation and cardiovascular effects. Since the cut-off size for both ultrafine and nanoparticles (100 nanometers in size) is the same, now both terms are used as equivalent. Based on the adverse effects of ultrafine particles as part of environmental pollution, engineered nanoparticles may be suspected of having similar adverse effects.
The company’s technology, validated by top scientists within the biotechnology stratum at the University of Pennsylvania, led the university to execute an agreement for the conduction of codevelopment activities with CCA and its NPC technology;
specifically, the creation of an effective delivery mechanism to the bloodstream and transmission across the Blood-BrainBarrier.
CCA is working together with the university and the Children’s Hospital of Philadelphia (CHOP) on the co-development of a new treatment for cognitive impairment resulting from TBI.
The university and children’s hospital have successfully validated the use of certain amino acids in the repair of brain tissue in the context of TBI;
CCA’s NPC technology shall provide a fast and effective, orally administered delivery mechanism across the BBB for this promising therapeutic. In simplest terms, CCA’s nanoparticle delivery complex acts as a guardian, shepherding a safe and controlled passage for healing drugs across the Blood-Brain-Barrier. Significant market potential for this co-owned technology is expected in the treatment of brain injuries from accidents and military injuries, and from the aging population, especially those with adult dementia.
Nanoparticles have enormous medical applications, beyond assisting in the treatment of TBI, providing massive advantages regarding drug targeting, delivery, and release over conventional drug delivery techniques. Nanoparticles are proved to be the best delivery systems for the treatment of a variety of neurodegenerative and virus generated diseases and potentially may be used in anti-tumor therapy, gene therapy, AIDS therapy and radiotherapy. More specifically, nanoparticles have wider application in brain tumor therapy, cancer treatment and Alzheimer’s disease.
This weekends $MILV DD bread crumb, one of many I just found this weekend
https://www.intechopen.com/books/molecular-insight-of-drug-design/multifunctional-nanoparticles-for-successful-targeted-drug-delivery-across-the-blood-brain-barrier
"The blood-brain barrier (BBB) is the major problem for the treatment of brain diseases because we need to be able to deliver drugs from the vascular system into the central nervous system (CNS).
There are no drug therapies for a wide range of CNS diseases and these include neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases and cerebral ischemia.
Therefore, the focus of this chapter is to discuss how nanoparticles (NPs) can be modified to transport different drug molecules for the treatment of brain diseases.
In essence, NPs’ surface can be functionalized with molecules such as peptides, antibodies and RNA aptamers and these macromolecules can be attached to the receptors present at the BBB endothelial cell surface, which allows the NPs cross the barrier and subsequently deliver pharmaceuticals to the brain for the therapeutic and/or imaging of neurological disorders.
In fact, part of the difficulty in finding an effective treatment for these CNS disorders is that there is not yet an efficient delivery method for drug delivery across the BBB.
However, over the last several years, researches have started to understand some of the design rules to efficiently deliver NPs to the brain."
Guess who those researchers are folks!!!!
The Ones creating NDT Pharmaceuticals Inc., by RM with $MILV
"This field holds the promise to deeply revolutionize the medicine to treatment and therapy areas such as imaging, drug delivery, cell therapy, tissue regeneration and development of new nanomedicine products. Due to its great importance, recent global marketed report expects that the applications of nanotechnology in medicine could reach $528 billion by 2019"
That sounds to me like a good reason to load $MILV since all the news in 1-24 days will be the last time we see sun penny $MILV shares.
keep $TWOH on your watchlist
https://finance.yahoo.com/quote/TWOH?p=TWOH&.tsrc=fin-srch
That is an interesting idea. We were just talking about doing some time line flow charts on the people behind $MILV next to help un-confuse the massive DD we have accumulated. Dr. Michael Fountain's awesome 131 issued US patent's history goes back 40 years. Hovis' drink lines resume goes back 20+ years. Mathias of the Carlyl group, must be huge...
Also we have a news date to watch for
https://www.alumni.upenn.edu/s/1587/gid2/wide_simple.aspx?sid=1587&pgid=28483&gid=2&cid=60319&ecid=60319&post_id=0
Can't Image Larry Kuban, 2 time NFL Superbowl winner and the face of the TBI brain injury and UPennMed efforts to solve the problems is causes not making a huge Public appearance and he is major shareholder in the firm R/M with MILV and bringing the Liposome drug delivery tech to $MILV. I might add that the contract Kubin/CCa, LLC is bringing to $MILV in the R/M is with the UPennMed-CBIR group listed below!!!
One of the top 4 brain injury hospital research teams in the world.
Nice post Mike....should label it as a FAQ .......
z
$MILV is stalking the land of silver now as it takes over penny land this week.
MILV Quiz
QUESTIONS (answers below)
A) Who does CCA have a contract to License their technology to?
B) What has CCA license to the University of Pennsylvania?
C) What does the CCA's management believes their technology could be used for with other pharmaceutical products?
D) What type of medical conditions do they believe their technology could be used to treat?
E) Who does CCA have a patent assigned from?
F) What Vitamin was being used by the writer of the patent as the bases of his encapsulated delivery system?
G) What does this paper have to do with the above?
Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model
https://clincancerres.aacrjournals.org/content/clincanres/early/2018/03/07/1078-0432.CCR-17-3811.full.pdf
Answers
A) University of Pennsylvania ("PENN") and the Children's Hospital of Philadelphia ("Children's Hospital")
B) CCA's Nanoscale Particle Complex (“NPC”) technology
C) a phospholipid-based nano-encapsulation drug delivery system
D) anti-cancer /general immunity modular pharmaceutical products and other pharmaceuticals (including oral, intra-nasal, and sublingual products (such as vaccines, anti-inflammatory products, analgesics, and anti-dementia, hepatic detoxification, and cardiovascular products) and topical products (such as anti-inflammatory products, analgesics, anti-infective agents (bacterial, viral and fungal) basal cell treatments and vaccines, and melanoma treatments and vaccines)).
E)Michael W Fountain
F)Tocopherol
G)Everything
All answers can be found in government and public documents
$RXMD on watch today, put it on top of your radar
$DLYT NanoClear™ Dais Analytic DLYT
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