vTv Therapeutics Inc (VTVT)

[crudeoil24]

VTVT > vTv Therapeutics Sees Positive Results From Dose Study for Psoriasis Treatment
6:21 am ET September 24, 2021 (Dow Jones) Print

By Chris Wack


vTv Therapeutics Inc. said it saw positive results from a multiple ascending dose study evaluating HPP737, an orally administered phosphodiesterase type 4 inhibitor for the treatment of psoriasis, in healthy adults.

The biopharmaceutical company said the trial enrolled 12 subjects in each of two dose cohorts, 15mg and 20mg, randomized to receive HPP737 or placebo orally once daily for 14 days.

Dose escalation up to 20mg/day demonstrated approximate dose proportional increases in exposure, while maintaining a favorable safety and tolerability profile with no dose limiting safety or tolerability findings observed. There were no serious adverse events and no discontinuations due to treatment emergent adverse events.

vTv said it believes that the current safety profile allows it to move forward in development with a drug that may achieve anti-inflammatory and anti-psoriatic responses without the significant safety issues of other PDE4 inhibitors.

With these results, vTv held a successful pre-IND meeting with the U.S. Food and Drug Administration Division of Dermatology and Dentistry. As a key outcome of the meeting, the company obtained acknowledgement that the completed studies appear reasonable to support the proposed dosing regimen of 20mg/day for 12 weeks.

The company also received feedback on the proposed safety monitoring and clinical trial endpoints. vTv plans to file an IND application later this year for a 12-week Phase 2 clinical trial evaluating the safety and efficacy of HPP737 in patients with moderate to severe psoriasis with study initiation targeted for early 2022.

vTv Therapeutics shares were up 31% to $2.32 in premarket trading.


Write to Chris Wack at [e-mail]


(END) Dow Jones Newswires

[TheFinalCD]

$VTVT Shorts are panicking, break of $3 will be huge

$VTVT Shorts are panicking, break of $3 will be huge

— BullishTrade (@Bullish_Trades) June 11, 2021

[TheFinalCD]

VTVT 2.69

$VTVT Swing starting, has the range to $3.50 area. Remember, juicy 20% short interest pic.twitter.com/t6WQQ2MaIA

— BullishTrade (@Bullish_Trades) June 10, 2021

There goes $VTVT squeeze over 2.79

— Antonio Costa (@ACInvestorBlog) June 10, 2021

[ALL-IN888]

ALL IN from 2.71 $$$ Bounce Target 3.17 Monday

[Nazirite]

$VTVT Breakthrough tag by
FDA. FDA has granted Breakthrough Therapy designation to its oral, investigational once-daily glucokinase activator, TTP399, as an adjunctive therapy to insulin for the treatment of type I diabetes.

[leonardo1]

No Shorting here see:

https://iborrowdesk.com/report/VTVT

[make it happen]

Book Value -$1.48, all cash flows extremely negative, Profitability all in the negative triple percentages and more.

Balance Sheet
Total Cash (mrq) 6.12M
Total Cash Per Share (mrq) 0.11
Total Debt (mrq) 915k
Total Debt/Equity (mrq) 24.12
Current Ratio (mrq) 1.13
Book Value Per Share (mrq) -1.48

Cash Flow Statement
Operating Cash Flow (ttm) -18M
Levered Free Cash Flow (ttm) -7.59M

Profitability
Profit Margin -132.51%
Operating Margin (ttm) -184.78%

Management Effectiveness
Return on Assets (ttm) -61.59%

[leonardo1]

There are no shares to short available so this could run hard..$$5/7/8

[ClayTrader]

* * $VTVT Video Chart 04-13-2021 * *

Link to Video - click here to watch the technical chart video

[Nazirite]

Great Day here $VTVT

[AlphaStockNews]

$VTVT is screaming for the top after the company announced that it received Breakthrough Therapy designation from the FDA. https://cnafinance.com/vtv-therapeutics-vtv-stock-climbs-on-breakthrough-designation/

[slyguy8888]

Running!

[ClayTrader]

* * $VTVT Video Chart 02-02-2021 * *

Link to Video - click here to watch the technical chart video

[daleb2130]

Nice job. LOL. Use Robinhood or TD. Neither charges fees LOL

[Investor2014]

Made 3 cents maybe just enough to pay the brokerage fee?

[daleb2130]

Taking my Chances. I just Bought back in at $2.06 After taking some nice profits here in Feburary

[jdheart101]

Big pipe line

[Investor2014]

Bad decision for him to have signed that vTv funding agreement back when. He is forced to buy on request from the company.

Folks needs to read and understand SEC filings, but clearly some have interpreted Perelman buying as sign of great things due.

[jdheart101]

Pearlman buys another 600 k plus @ 1.60 11% + owner

[mclaxer5155]

Chat rooms are pushing this again

[mclaxer5155]

Buy it up

[ShortSale4U]

Why you were sleeping VTVT dropped over 100 point and continues to fall. This to me has went to junk status overnight. let see if the bleeding continues or somehow it will be salvaged.

[mclaxer5155]

Lots of rumors in the chat rooms this am

[Covert9classified]

1.30 tomorrow. Will be a sad day for baggies.

[cablejohn]

ouch gap down

[mclaxer5155]

Remember I told you

[cjstocksup]

Todays news was great this AM but the afternoon results were just OK. The play was the dip below $2.00 afterhours and sell at $2.40 here. I guess we wait for the next catalyst.

[cjstocksup]

One of these days VTVT should run over $8.00 to $10.00 IMO. We are close to another major run.

[ShortSale4U]

This day was discouraging.. One good point we left off where we closed yesterday. a .53 decline from the beginning. hope it hold.

[ShortSale4U]

This company could use some help with their outdated web page and invest in some PR to help them be noticed. Hard to believe a company moved downward on good news.

[ShortSale4U]

Big stock turnover, i guess we need new investors, the old ones are impatient.

[cjstocksup]

Very low volume not many people know about the VTVT news. The bigger news is ahead.

[ShortSale4U]

Selling on good news. Really!!!!

[ShortSale4U]

Not really a gap normal trading , not a company push up.

[ShortSale4U]

Monster news a lot of people loss a great deal of money today > so so many unnecessary sells , this could already be 5.00 a share. Good luck to all that stayed!!!!!!!

[cablejohn]

the wonderful gap up

[cjstocksup]

Oh by the time you get out it will double again just like it did last week!
VTVT

[mclaxer5155]

All sells! Get out! Now!

[ShortSale4U]

Scoop them up . great sale. wont go much lower.

[cablejohn]

[cjstocksup]

$VTVT
https://www.bloomberg.com/news/articles/2020-12-11/perelman-s-vtv-therapeutics-doubles-ahead-of-alzheimer-s-results

[ClayTrader]

* * $VTVT Video Chart 12-11-2020 * *

Link to Video - click here to watch the technical chart video

[cjstocksup]

I have been in VTVT a long time IMO we are golden shorts have been working it since the open with puts etc. They will cry next week IMO we saw $6.50 plus pre market today next week we could see $10.00 on a cover.

[ADenn]

Today we have traded double the authorized shares and 10x the float, and only up 54% WTH

[ADenn]

Was that the run? Over now?

[Jess070283]

Load em up!$$$$

[jdheart101]

Whole float traded over the last 24 hours

[cjstocksup]

VTVT what fun pre market!

[jdheart101]

VTVT
Float 10.4M Shares
Outstanding 67.8M
Institutions Holding Shares 26
Held by Institutions 12.37%

[jdheart101]

15% short