Replies to post #158924 on Avid Bioservices Inc (CDMO)

[InternetForumUser]

Appreciate it.. I had to work all night and when I was visiting the Archived Events, I overlooked the Link.

Thanks again.. BTW, I went through all of your posts and I do agree with everyone else, that you do provide very good information.

Thanks again.

[atonewith PPHM]

Free,
Under Immunotherapy Checkpoints: Potential Synergies Between Upstream and Downstream Targets
Y = Bavituximab Y = Anti-PD-1, Anti-PD-L1, Anti-CTLA-4

While they didn't specifically show a graph of PD-1 and PD-L1 results they showed pictures of the PD-1 receptor being covered (shown as purple Y) being lumped in with the results of CTLA-4 as if the outcome was the same. If you notice the receptors are PD-1 not CTLA-4. Doesn't it seem strange that if they are just talking about CTLA-4 they would have at least shown the receptor?
Then under 3. Sustained Immune Response, they had this sentence.
Anti-PD-1 and CTLA-4 inhibits the generation of immunosuppressive T-regs and maintains a cytotoxic T- cell response
Thats about as close to saying that the PD-1 receptor works the same as CTLA-4 as I think you can get. Why they aren't saying it outright yet is the question. What is going on behind walls of our little PPHM? ;) Good stuff I think!
AtonewithPPHM