Replies to post #20558 on Biotech Values

[rfj1862]

OTC Niacin

Another difference is, of course, the prescription niacin is much higher dose than anything you can get OTC. At least if you follow the dosing recommendations.

[ipollit77]

MK-0524A vs. ARNA HDL comp?

how is MRK’s MK-0524A related to ARNAs HDL compounds in phase I?

We believe one or more of these GPCRs plays a role in regulating plasma lipid profiles, including HDL cholesterol, the so-called ‘‘good cholesterol,’’ and is responsible for the HDL-raising activity of niacin. In October 2004, Merck extended and expanded our collaboration and selected one of our compounds for preclinical development. Merck initiated a Phase 1 clinical trial evaluating that compound in July 2005.

http://www.forbes.com/sciencesandmedicine/2005/11/28/pfizer-cholesterol-hdl-cx_mh_1128hdl.html
But use of niacin is limited by flushing that prevents many patients from taking it. Merck's entry in the HDL wars, developed with San Diego-based Arena Pharmaceuticals (nasdaq: ARNA - news - people ), are working on a modified niacin that does not cause flushing.

[urche]

MRK'S ANTI-FLUSHING COMPOUND

Anyone have any idea what this is? Perhaps in the family of non-steroidal antiinflammatory drugs like aspirin. I am wondering if the drug could also be applied to the problem of hot flashes in the menopausal syndrome (and some cases in which hormones are therapeutically ablated). Menopausal symptoms are a much bigger unmet need since estrogen became a naughty word.

urche