Replies to post #1061 on SCIENCE SPIN-OFFS

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Method for Nano-Encapsulation of Ingestible Compounds
Track Code 26074
Short Description None
Abstract Challenge

Encapsulation methods are often used to protect reactive substances for improved processing and product stability. These methods are especially important in the food and pharmaceutical industries where increased shelf life, facile processing, and controlled dosing are desired. Coacervation is the most commonly used method of encapsulation due in part to its high encapsulation yield. Coacervation refers to the adsorption of phase-separated aggregates around a core material. Current coacervation processes require multiple pH adjustments and the use of toxic cross-linking agents such as formaldehyde. The use of these toxic compounds is undesirable for food and pharmaceutical applications.

Solution

The present method provides for the nano-encapsulation of ingestible compounds in which hybrid structures of anionic and cationic polyelectrolytes form a coating around hydrophobic core particles. The method also relies on charge-mediated complex coacervation but does not require lengthy pH adjustment steps or the use of toxic cross-linking agents. As a result, this method is capable of generating nano- and mesocapsules in a simple, fast, and cost-effective manner. The resulting paste-like solid is easily manipulated, forms stable suspensions in water, and can be blended with other substances to form powders.

Benefits and features

?Small size of capsules render them bioavailable
?Method does not require toxic cross-linking agents or time-consuming pH adjustment steps
?Method carried out in water at mild temperatures
Market Potential / Applications

This method has potential application in the food and pharmaceutical industries, as it could allow for improved processing, shelf life, and taste performance of ingestible compounds with nutritional benefits.
Development and Licensing Status

This technology is available for licensing from Rice University.

Rice Researcher

Michael S. Wong is Professor in the Chemical and Biomolecular Engineering Department and the Chemistry Department at Rice University. He serves as Associate Editor of the Journal of Nanomaterials and Editorial Board Member of Chemistry of Materials. His research interests encompass nanostructured materials chemistry, heterogeneous catalysis, water cleanup, and encapsulation/delivery applications. Among other recognitions, he is an MIT TR35 Young Innovator Awardee, a Smithsonian Magazine Young Innovator Awardee in the Arts and Sciences and a AIChE Nanoscale Science and Engineering Forum Young Investigator.Technology Relevant Papers and Web Links

A U.S. patent application has been filed for this technology (PCT publication no. 2008063158).

Case # 26074

Key Words: formulations, food, pharmaceuticals, encapsulation, processing, coacervation, nanocapsules

Inquiries to:

Luba Pacala, [e-mail], [phone]

Chance Rainwater, [e-mail], [phone]


Tags formulations, food, pharmaceuticals, encapsulation, processing, coacervation, nanocapsules

Posted Date Jan 12, 2011 5:27 PM