Replies to post #33857 on RespireRx Pharmaceuticals Inc (RSPI)

[Midasbro]

AC IMMUNE ACI-518 (AMPAkine Program)
AMPAkines are positive modulators of AMPA receptors, the non-NMDA ionotropic receptors for glutamate involved in long-term potentiation processes and short-term memory in humans. ACI-518 is a patent-protected lead molecule of the class of AMPAkines developed from the State University of Moscow. ACI-518 shows the highest reported receptor affinity and is a very innovative approach to enhance the AMPA receptor function. AC Immune has acquired an exclusive license from the State University of Moscow and uses its proven expertise in preclinical development of Alzheimer´s treatments to move the compound forward quickly towards clinical development.


http://www.acimmune.com/content/?p=42

[neuroinv]

8529 is a mGluR2/3 'positive allosteric modulator', 8418 probably is too--mGluRs have been the glutamatergic target AZ has pursued for the past....fifteen years. So they are not AMPA receptor modulators.

NeuroInvestment