Is this a fact?
Let's put it this way... it's NOT sooooo complicated. How to grow the cells, including the exact forumulation of the growth media would've been defined by Eurofins in their documentation. If ZN in Thailand can't follow a simple recipe for a growth medium, then they should try hiring in a US 1st yr grad student as a summer coop.
AN claims they can encapsulate ANY cell line successfully. Back in 18-Sep-18 they claimed to have completed all required "manufacturing runs".
Then one has the possibilities:
No set procedures are being followed, and everything is slop. Forget about the mythical IND dream.
or
The problem(s) is not the ability to grow the cells, and successfully encapsulate them.
If the later (SHs better hope), then what is left? The genetics of the cells become unstable, and/or the enzyme production non-reproduce able, as a result of the mechanics of encapsulation/freeze-thaw within the capsules. Then again, maybe SH's better not hope for this.
Note there is nothing soooo complicated about growing the cells, or encapsulating them. However, given their history when they arrived at Eurofins, keeping the cells stable might be a little complicated.
Also should be noted, the whole concept of placing CIABs near a pancreatic tumor in the hope of converting just enough more Ifosfamide locally (*) to make a difference isn't bleeding edge science. It's simplistic in concept. Also antiquated, and DOA.
(*) Maybe someone who is fluent in fluid mechanics can figure how how much of a 1 mg/m2 dose of Ifosfamide would ever be converted locally. That would bee complicated.
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