Well a lot of luck. I am only a year into penny stocks. So here was my worst decision. I was in MINE. I bought heavy $25,000 at .0045 and .0046. It exploded to .004 which would have been well over 200k for me. i was optimistic that the company would do even better over time. I was in it for a year and the current pps is now back down to .005s
Moral of the story is that you gotta secure profits when they are available and reduce risk when you can. I do a lot of chasing in the pennies too. If you see a mover get in and make a few bucks and jump out safely. A few dollars profit per day can add up to thousands a month. I came to pennies from the big boards so I was already established. It takes time and effort but it can be done. I am a very passionate and crazy investor too and you need to be both to do well.
Follow trends and read all the news you can. Look at emerging markets as try to find new companies that offer shares that look solid.
Still it is all luck in the end. This one with the right news could help you get closer to retirement.