Replies to post #11470 on NorthWest Biotherapeutics Inc (NWBO)

[bjoel5150]

left a nasty reply to his article. Knocked the price down 30 cents in after market trading. We'll see what happens tomorrow.

[BioInfo]

we are not thru 100% of treatment, only 3-injections and we are at 28%, no one should say its ineffective, its a great achievement if you ask me.

Buy panic and that is what AF is doing!

[ou71764]

I know Pyr says this is the old standard and I also know that Wikipedia is not a definitive source, but here is what they say:

Complete Response (CR): Disappearance of all target lesions

Partial Response (PR): At least a 30% decrease in the sum of the LD of target lesions, taking as reference the baseline sum LD

Stable Disease (SD): Neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD, taking as reference the smallest sum LD since the treatment started

Progressive Disease (PD): At least a 20% increase in the sum of the LD of target lesions, taking as reference the smallest sum LD recorded since the treatment started or the appearance of one or more new lesions

http://en.wikipedia.org/wiki/Response_Evaluation_Criteria_in_Solid_Tumors

[Chiugray]

Afford - The fallacy to AF's article on the 28% tumor reduction equating to no-efficacy is this:

1. Tumor size and reduction is not a valid measure when the trial is not complete yet, particularly when patients have not even received the full set of treatments. The reason is during the initial stage, when the T-cells (B-cells, macrophages, etc) are fighting the cancer, the tumor will actually increase in size because T-cells are stuffing themselves inside the tumor. It is only afterwards when the dead cancer cells are cleansed away that the tumor size will shrink. The fighting is still in process.

2. Tumor necrosis, on the other hand, can present a snapshot view of biological activity or efficacy. The measurement process though would be based on doing a biopsy to determine whether or not the tumor contents indeed include T-cells (active) and cancer cells (dead). Tumor size does not show this.