Fuse Science Inc (DROP)

[Long-vestor]

Surprise me Smith. For all the time, the effort, you haven't read or understood the patent behind Enerjel?

but here's a part and your ingredients too:

EXAMPLES

[0061] This section describes several examples of more specific transdermal compositions and methods for making them. It also presents experimental data highlighting the effectiveness of the transdermal compositions for transdermal delivery of active ingredients. These examples do not limit the scope of the various aspects and embodiments of the invention in any way.

Example 1

Liposomal Composition

[0062] A liposomal composition, in accordance with a composition aspect of the invention, is provided in Table 1. This exemplary composition includes the active ingredients caffeine and white willow bark, which are liposomally encapsulated. With these active ingredients, the composition functions as a topical transdermal stimulant and analgesic delivery vehicle.

Table 1

Ingredient % by weight (w/w)

Water, Purified USP 81.03%

Genu Pectin 3.95%

Phosphatidylserine 2.00%

Glycerin 99.7% USP 2.00%

Sodium Hydroxide 0.20%

Caffeine Anhydrous, USP 5.00%

Menthol Crystals BP/USP 3.80%

White Willow Bark 2.00%

Sodium Benzoate 0.02%

Total : 100.00%

[0063] The composition of Table 1 was prepared according to the following procedure. Purified USP water was heated to approximately 78-85°C (172-185°F) in a heating tank. The water was charged to a mixing container, and blended using a high- shear variable speed mixer at 1000 rpm. While blending, phosphatidylserine was charged to the mixing container.

[0064] Still blending at the same speed, sodium hydroxide was charged to the mixing container. This solution was mixed at 3600 rpm for 2-3 minutes. The speed of the mixing was then returned to 1000 rpm while the anhydrous caffeine and white willow bark were added to solution. The solution was then blended at 3600 rpm until the appearance of homogeneity was reached .

[0065] The mixing was halted, and the solution rested for about 5-7 minutes, allowing the solution to slightly cool. The mixing was resumed at 1000 rpm and the glycerin was added to the solution. Then the mixing was sped up to 2000 rpm until the appearance of homogeneity was reached.

[0066] The solution was then mixed at 1000 rpm, and menthol and sodium benzoate were added, in that order. Once all of these were added to the solution, the speed of mixing was increased to 2000 rpm and blended until the appearance of homogeneity was reached.

[0067] Mixing was continued at 1000 rpm and the pectin was added. Mixing speed was increased to 2000 rpm and the pectin was added to the solution and blended until the appearance of homogeneity was reached.

Example 2

Colloidal Composition

[0068] A colloidal composition, in accordance with a composition aspect of the invention, is provided in Table 2. This exemplary composition includes the active ingredients caffeine and white willow bark in a colloidal suspension. With these active ingredients, the composition functions as a topical transdermal stimulant and analgesic delivery vehicle.

Table 2

Ingredient % by weight (w/w)

Water, Purified USP 81.17% Genu Pectin 3.95%

Glycerin 99.7% USP 2. 00%

Grapeseed Oil 2. 00%

Caffeine Anhydrous, USP 5. 00%

Menthol Crystals BP/USP 3. 80%

White Willow Bark 2. 00%

Niacin 0. 05%

Potassium Chloride 0. 01%

Sodium Benzoate 0. 02%

Total : 100 .00%