Tekmira Pharmaceuticals Corp (TKMR) (TKMR)

[Ubertino]

United States Patent Application 20130022649 Yaworski; Ed; et al

January 24, 2013

SNALP FORMULATIONS CONTAINING ANTIOXIDANTS

Abstract
The present invention provides methods of preventing, decreasing, or inhibiting the degradation of cationic lipids and/or active agents (e.g., therapeutic nucleic acids) present in lipid particles, compositions comprising lipid particles stabilized by these methods, methods of making these lipid particles, and methods of delivering and/or administering these lipid particles, e.g., for the treatment of a disease or disorder.

Inventors:
Yaworski; Ed; (Maple Ridge, CA) ; Heyes; James; (Vancouver, CA) ; Judge; Adam; (Vancouver, CA) ; Reid; Stephen; (Surrey, CA) ; MacLachlan; Ian; (Mission, CA)

Assignee:
Protiva Biotherapeutics, Inc.
Burnaby
BC

Claims
1. A method for preventing, decreasing, or inhibiting the degradation of a polyunsaturated cationic lipid present in a nucleic acid-lipid particle, said method comprising: including an antioxidant in said nucleic acid-lipid particle, wherein said antioxidant comprises ethylenediaminetetraacetic acid (EDTA) or a salt thereof, and wherein said nucleic acid-lipid particle comprises a nucleic acid, said polyunsaturated cationic lipid, a non-cationic lipid, and a conjugated lipid that inhibits aggregation of said particle.

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http://www.patent2pdf.com/pdf/20130022649.pdf