Quantum Materials Corp. (fka QTMM)

[lineman68]

Nano-Technology Uses Virus' Coats to Fool Cancer Cell


ScienceDaily (Feb. 17, 2012) — While there have been major advances in the detection, diagnosis, and treatment of tumors within the brain, brain cancer continues to have a very low survival rate in part to high levels of resistance to treatment. New research published in BioMed Central's open access journal Journal of Nanobiotechnology has used Sendai virus to transport Quantum Dots (Qdots) into brain cancer cells and to specifically bind Qdots to epidermal growth factor receptor (EGFR) which is often over-expressed and up-regulated in tumors. By molecular-labeling cancer cells this nanoparticle technology could be used to aid diagnosis.


--------------------------------------------------------------------------------

See Also:

Health & Medicine
•Brain Tumor
•Cancer

Mind & Brain
•Brain Injury
•Neuroscience

Matter & Energy
•Biochemistry
•Organic Chemistry

Reference
•Natural killer cell
•Colostrum
•Monoclonal antibody therapy
•Nanomedicine


Qdots are tiny fluorescent particles, smaller than a virus, and over 1000 times smaller than a cell, which can be linked to biological molecules, such as antibodies. Once linked, the fluorescence would make it easy to find which cells contain the protein the antibody recognizes, and where in the cell this protein is located. However there have been problems getting the Qdots into cells without them clumping, or being packaged in to endosomes, and excreted from the cells as waste.

Researchers from the City College of New York have overcome this problem by coating the Qdots in lipid and protein coats based on Sendai virus. Prof Maribel Vazquez explained, "While cells have complex defense mechanisms to protect themselves against attack, viruses have evolved ways to fool the cell into letting them in. We were able to exploit these mechanisms by fusing inactivated mouse parainfluenza virus with liposomes containing Qdots. The Qdots were in turn attached to an antibody against EGFR. So, once inside the cell, the Qdot-antibody complexes were able to bind to the receptor and the amount of bound complex could be monitored by measuring Qdot fluorescence."

This study looked at the level of EGFR as a marker for cancer but the Qdots could be attached to any antibody. Antibody-Qdot sets would allow rapid identification of different cancer types, determine potential chemotherapy resistance, and lead a more individualized treatment plan.

Recommend this story on Facebook, Twitter,
and Google +1:






Other bookmarking and sharing tools:


| More

--------------------------------------------------------------------------------

Story Source:


The above story is reprinted from materials provided by BioMed Central Limited, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


--------------------------------------------------------------------------------

Journal Reference:
1.Veronica Dudu, Veronica Rotari, Maribel Vazquez. Sendai Virus-based Liposomes Enable Targeted Cytosolic Delivery of Nanoparticles in Brain Tumor-Derived Cells. Journal of Nanobiotechnology, 2012; 10 (1): 9 DOI: 10.1186/1477-3155-10-9



Need to cite this story in your essay, paper, or report? Use one of the following formats:

APA

MLA

BioMed Central Limited (2012, February 17). Nano-technology uses virus' coats to fool cancer cell. ScienceDaily. Retrieved February 18, 2012, from http://www.sciencedaily.com­; /releases/2012/02/120217101705.htm


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.



Ads by Google

--------------------------------------------------------------------------------

Cancer Care Options — Innovative therapies. Conventional treatments. Learn your options.
?Cancer?Center?.com?/?Care?That?Never?Quits

(5) Signs Of Depression — These 5 Symptoms Of Depression Will Shock You. See The Causes Now.
knowwhatsbest?.com

New Hope for Cancer — Noninvasive alternative treatments to rebuild the immune system.
newhopemedicalcenter?.com

5 Foods you must not eat: — Cut down a bit of stomach fat every day by never eating these 5 foods.
?Beyonddiet?.com

2 Fruits Can Kill Cancer — Free report reveals two fruits that that can kill cancer, plus 7 more
www?.doctorshealthpress?.com


Related Stories

--------------------------------------------------------------------------------


Nanotechnology May Speed Up Drug Testing (Jan. 6, 2012) — Testing the effectiveness of new pharmaceuticals may get faster thanks to a new technique incorporating quantum ... > read more

Significant Benefits In Non-Small-Cell Lung Cancer From Customizing Erlotinib Treatment (Sep. 15, 2008) — Lung cancer patients whose tumors carry specific genetic mutations can achieve significantly longer survival when treated with targeted therapies such as erlotinib, researchers ... > read more

Researchers Identify a Potential Therapeutic Target for Brain Cancer (Feb. 23, 2010) — Researchers report the identification of a protein that is highly expressed in a subgroup of glioblastoma brain tumor cells and show that depletion of this protein increases the survival of mice with ... > read more

Increased EGFR Levels May Be an Early Marker of Breast Cancer (Apr. 21, 2010) — Levels of epidermal growth factor receptor (EGFR) may be elevated in the blood of women within 17 months prior to their breast cancer diagnosis, according to new ... > read more


Ads by Google

--------------------------------------------------------------------------------

Brain Training Games — Improve memory and attention with scientific brain games.
www?.lumosity?.com

Heal Your Depression — Top 5 Signs Of Depression. Treat Your Symptoms & Heal Now!
www?.northhillshealth?.com

Create an Exercise Plan — Build a Custom Plan Here Based on Your Goals and Favorite Activities.
merckengage?.com




Search ScienceDaily

Number of stories in archives: 115,064


--------------------------------------------------------------------------------



Find with keyword(s):




Enter a keyword or phrase to search ScienceDaily's archives for related news topics,
the latest news stories, reference articles, science videos, images, and books.









Just In:
















Why Do Dinosaur Skeletons Look So Weird?

more breaking science news

Social Networks

--------------------------------------------------------------------------------

Recommend this story on Facebook, Twitter,
and Google +1:






Other bookmarking and sharing tools:


| More



Breaking News

... from NewsDaily.com


--------------------------------------------------------------------------------





China to launch next manned spacecraft in summer
China to launch next manned spacecraft in summer
Tasmanian devil genome mapping may help humans too
Spacewalkers prepare Russian module for dumping
Spacewalkers prepare Russian module for dumping
more science news

In Other News ...
Italy police seize $6 trillion of fake U.S. T-bonds
Dutch prince in critical condition after Austria avalanche
Ex-Goldman programmer's conviction overturned
Murdoch pledges "unwavering support" to UK Sun
Murdoch flies in to meet with angry British staff
Murdoch flies in to meet with angry British staff
Murdoch flies in to meet with angry British staff
Insight: Japan slowly wakes up to doomsday debt risk
more top news


Copyright Reuters 2008. See Restrictions.

Free Subscriptions

... from ScienceDaily


--------------------------------------------------------------------------------

Get the latest science news with our free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:
Email Newsletters
RSS Newsfeeds


Feedback

... we want to hear from you!


--------------------------------------------------------------------------------

Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?


Your Name:
Your Email:
Comments: