I'm not aware of any sub-q work with ERT, It will be very difficult to do as the volume is huge and so, if it requires more than say a daily injection in a physician's office then not viable commercially speaking. There are attempts to improve delivery/efficacy of ERT via encapsulation within liposomes or RBC, but didn't see any of these strategies moving to the clinic. Except for the intrathecal delivery for ERT that you've mentioned, PLX is working on oral ERT but very early in development. Genzyme and Amicus as we've discussed elsewhere, are working on oral small molecules, which are not ERT and I'm quite optimistic at least with one, but you know that too
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