Lifeline Therapeutics (fka LFLT)

[Steeley]

"Protandim"
because it "promotes tandem" up-regulation of Superoxide dismutase, catalase and glutathionne peroxidase (SOD, CAT, GPX) - the body's antioxidant enzymes

Company website
http://www.lifelinetherapeutics.com/index.htm


Faq
http://www.protandim.com/faq.htm


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Does a New Pill Contain the Fountain of Youth?
Protandim May Slow Aging Process by Increasing Enzymes That Fight Free Radicals
Jun. 2, 2005 - Dr. Joe McCord's latest research may unravel the mystery of aging. And if he succeeds, the answer could come in the form of a little yellow pill called Protandim.
The University of Colorado at Denver biochemistry professor has conducted decades of experiments into a special class of enzymes in the cell that some hope have the potential of extending lives and possibly preventing chronic diseases like cancer, diabetes and heart disease.
Much of his work has centered on oxidative stress -- which increases with age. TBARS, which are a measure of oxidative stress, can also be a rough indicator of a person's actual age.
But, McCord has found that the ingredients in Protandim lowered the test subject's level of oxidative stress.
"They all are reduced to the level of oxidative stress that one would expect, frankly, in a newborn. Or a very young child,' he said.
Dangerous Radicals
To be sure, there have been other supposed "miracle" drugs and treatments that never delivered on their promise to delay or even stop human aging. But McCord, research director in the company that makes Protandim, believes this pill might be different.
To understand how Protandim works, you have to first understand how aging occurs.
Aging is "a slow progression of oxidative stress," McCord said. Much of oxidative stress comes from the basic function of eating.
As cells burn food, they also release toxic chemicals known as "free radicals" which cause cell damage and consequently -- oxidative stress.
The body fights back by making two anti-oxidant enzymes -- Catalase and SOD. But as people get older, those enzymes can get overwhelmed.
For a long time, scientists thought that anti-oxidant vitamins like C and E could lower oxidation, but many experts now believe they aren't effective.
Protandim, McCord said, is much more powerful. Tests on both mice and humans have already shown that it revs up the body's manufacture of those enzymes -- thereby reducing the presence of those harmful free radicals.
However, McCord cannot say at this point whether or not Protandim could lead to a longer life. Experiments to see if mice live longer are about to get under way.
Studies have not yet been conducted to determine whether Protandim can prevent disease.
"Right now, all we know is that this preparation decreases oxidative stress. Oxidative stress is not a disease, just like aging is not, in itself, a disease," he said. "But it's something that accompanies, and is attached to, many disease processes."
The Power of Enzymes
McCord said Protandim could be "something that will tell us a lot more about how we age, what happens biochemically. And maybe how we can slow it down."
And there is some other promising independent evidence that seems to back him up.
Dr. Douglas Wallace of the University of California at Irvine conducted an experiment and found that mice that have been genetically engineered to produce more catalase, one of the enzymes that Protandim increases, lived about 20 percent longer.
Wallace believes that with better techniques the lifespan for humans can eventually be extended too. "We might be able to increase the lifespan by 50 percent. And of course if that was a human being, then that might be in the order of 130 to 150 years," he said.
Dr. Michael Brownlee, who heads the Center for Research on Diabetic Complications at Albert Einstein Medical College, conducted another experiment involving another enzyme boosted by Protandim called SOD.
He tested diabetic mice and found their wounds simply don't heal -- a problem common for diabetics. But when another diabetic mouse that was genetically engineered to have more SOD was wounded, it healed much better.
"Even though they were diabetic, they healed, just like the normal," he said. "It is a breakthrough."
Secret Formula
Protandim may seem to have incredible potential, but its roots are actually very humble.
It is a combination of five plant ingredients. Two of them are pretty commonplace -- green tea and turmeric, a spice used in Indian cooking. The others, among them withania somnifera and silybum marianum, are more exotic.
"There's a huge human experience with each of these ingredients," McCord said. "They've been used often in traditional medicine in India and China and many other cultures in some cases for centuries and centuries."
And that experience, plus his tests on human subjects so far, indicates that the ingredients are safe.
And so, ancient Eastern healing and modern Western medicine may soon be working together.
High oxidative stress is associated with more than aging. It's been linked to hundreds of illnesses, from cancer to heart disease to Parkinson's and even depression.
But McCord said: "We make no claims about curing any disease, or preventing any disease. We hope that when enough studies are done, perhaps such claims might be made in the future."
Because Protandim is composed of herbal ingredients with a long history of use, it is being marketed as a nutraceutical, and does not require FDA approval.
However, the company is planning further clinical studies in three to four months to assess Protandim in both diabetes and heart disease, which will be submitted for substantiation.

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Colo. Doctor Invents 'Anti-Aging' Pill
Protandim Claims To Slow Down Aging Process
POSTED: 10:08 am MDT June 3, 2005
UPDATED: 11:10 am MDT June 3, 2005
DENVER -- A Colorado doctor has invented a supplement that he says slows the aging process and could possibly prevent diseases. The pill is called Protandim, a natural supplement that he claims can change the chemistry of the body.
The supplement makes you healthier, but you don't feel any changes, said Protandim's manufacturer.
One of the trial participants 7NEWS spoke with said that besides a slight peak in energy, he didn't notice any changes. But Leigh Severance swears by this new "anti-aging" pill. He said he'll take it until the day he dies but jokes that if the pill really works, he'll be around for a long time.


Severance is 66 years old, partially retired and lives on a golf course. But he said, on the inside he's really 22 years old. But he doesn't attribute his youthful feeling to a midlife crisis or his Porsche.
Severance is taking Protandim, an antioxidant supplement he says eliminates age-related oxidative stress. Oxidative stress is when you have too many free radicals in your system and not enough antioxidants.
"When you have too many oxidants, cells become damaged, all of the main classes of molecules get oxidized and damaged," said Dr. Joe McCord said.
McCord, who is with the University of Colorado Health Sciences Center, formulated Protandim.
"Oxidative stress is probably the main biochemical marker of the aging process, So if want to know how old an organism is, you can measure oxidative stress level and it will give you an idea," said McCord.
He said the pill can lower that level of oxidative stress by revving up your natural antioxidants. And that, in turn, makes people like Severance 22 years old, McCord said.
Or at least when it comes to his oxidative stress levels.
"It's getting rid of millions of free radicals," said Severance. He hopes it's helping him live longer.
"I've told my kids that they need to be taking it," he said.
McCord said oxidative stress often accompanies many diseases like cancer, diabetes and Alzheimer's disease. So now that he says his supplement helps healthy people, he plans on studying how it will affect those already suffering with diseases and how healthy people may be able to avoid getting sick in the future.
More Information:
Protandim is available online at Protandim.com or by calling [phone] (1-8-Protandim)