DCTH: ADAM F thinks its not great stuff. why i think 180 degree opposite.
I think it should be game changer the way you treat melanoma mets.
Can some body ask adam big..., is there any effective therapy for metastatic melanoma, answer is no.
PHP reduces the tumor burden in the liver( one of the most common organ in metastatic disease which shortens the life span and quality of life) without infusing large quantity in the system. I mean it does infuses large quantity in the tumor but at the same time the great php system removes it out from the veins(IVC and hepatic vein). this large quantity of melphalan does dramatic effect on the the tumor per phase III and theoratically that sounds good too. can you give that large quantity without PHP. No, patient will die on table.
They are doing study in HCC also. some times advanced hcc tumor need localized therapy. I am an interventional radiologist, i do Rf ablation of tumor and chemoembolization of HCC, but if there are multiple tumor , large in size, and if trial improves survival with stastical significance, which i think it should,( time will tell) , it will be huge. in taiwan they are doing php phase one with doxrubicine, which is drug of choice for hcc.
what ever i understand it looks really promising, with bio techs you can miss important point even with all the knowledge. That's where sheff comes in to play. but i am definately looking to start some position some time.
AI
