AEterna Zentaris (AEZS) is a undiscovered biotech company with multiple pahse III, phase II, phase I and several promising preclinical cancer drugs. They have almost no debt ($300k), $40mln cash, only 115mln mcap with low $6 mln cash burn.
Perifosine, first-in-class oral AKT inhibitor Multiple Myeloma (phase III) Advanced Colorectal Cancer ( phase III to start soon) Kidney Cancer (phase II) and Others / AEZS licensed N.American rights to KERX, which pays for trials costs and 11% royalties of potential futures sales. AEZS is holding the rights for rest of world, wich is as big as north american market excluding South-Korea.
AEZS-108 Endometrial Cancer (phase II, final results end of 2010) Ovarian Cancer (phase II, final results end of 2010) Bladder Cancer (phase II start end of 2010) Other Cancers
AEZS-112 (phase I) Solid Tumor
AEZS-120 *Tumor Vaccine, (pre-clinical), phase I start in mid to second half of 2010 / similar to DNDN's Provenge Prostate Cancer
AEZS-129/131PI3K/ErkInhibitor (pre-clinical) / Similar to Ariads ridaforolimus, licensed to Merck for up to $500mln
AEZS-127 Intravenous administrionable Perifosine And here is AEZS masterplan:
Once KERX does pays all the trials for Perifosine and the drug succeeds, AEZS will present Perifosine II, intravenous injectable and thus very likely more efficient Perifosine:
AEZS-127 (Erucylphosphocholine (ErPC)) is an analog of perifosine which is suitable for intravenous administration. Like perifosine, AEZS-127 belongs to a new class of compounds based on alkylphosphocholines that Æterna Zentaris has developed in our Drug Discovery group. AEZS-127 possesses distinctive reduced hemolytic activity thus allowing for intravenous injection. Æterna Zentaris owns the worldwide rights.
Cetrotide® (Marketed by Merck Serono, Nippon Kayaku / Shionogi (Japan)) In VitroFertilization, AEterna gets around $6 mln per quarter
AEZS-130 (SolorelTM) Diagnostic – Adult Growth Hormone Deficiency, phase III
AEZS-130 has shown to stimulate appetite and therefore could be used to treat cachexia, a condition which results in a severe reduction of muscle mass and weight loss in patients suffering from conditions such as chronic obstructive pulmonary disease, AIDS and certain cancers. Potential update in 2010.
IMO, based on AEterna's great pipeline of late stage cancer drugs, she should be trading well over $8 and could be taken over for $15 per share. I think, AEZS is a multi-bagger and worth doing your own DD. If there's no buyout and Perifosine is marketed, AEZS could be a 100-bagger, a 10.000% chance.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.