Entremed (ENMD)

[docaaron1]

Nottadoc, that article was a bit hard for me but I took it as good. The way I understood it was BRCA1 inhibits tumor, Aurora kinase A inhibits BRCA1

Hence ENMD 2076 inhibits Aurora Kinase A which stops the inhibition of BRCA1 so it can inhibit the tumor.

Aaron

From the last paragraph of the link: “AURKA is an oncogene that is overexpressed in 62% of breast cancers (44). BRCA1 is phosphorylated by AURKA (37) and overexpression of AURKA leads to phenotypes similar to those associated with BRCA1 knockdown, i.e., absence of the G2-M checkpoint (45) and centrosome amplification (46). Therefore, we propose that these two proteins are part of the same regulatory pathway that is responsible for the control of centrosome function, and a delicate balance in the activities of these two proteins is crucial for tumor suppression.”