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Re: enemem post# 15957

Tuesday, 03/11/2008 9:57:04 PM

Tuesday, March 11, 2008 9:57:04 PM

Post# of 51786
Then you have to differentiate what is causing the adipose tissue in collapsing the airway. Or what is causing the mechanical apnea. It's probably not the adipose tissue, that would always be there, nice visual-beer gut swaying dependent on gravity. Where's the liposuction on that belly.

Now, if there is a tonal pathway abnormality causing hypotonia which then facilitates the mechanical obstruction when trying to sleep, the question could be; could ampakines facilitate the normalization of tone.

For thought, striated muscle tone is affected by afferents/efferents from the segmental level, various intra/extrafusal spindle fibers and other sensory organs, but there is also a vertical association UMN to LMN from more central regions on tone.

Could the central rhythm-generating networks, P.D. complex, ampakine affecting regions stimulate vertical pathway changes that facilitate peripheral pathway normalization and normalization of tone.

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