Dendreon Corp fka DNDNQ

[rancherho]

Too little of a good thing (macrophage activation) can also be a bad thing.See a new study published in Nature: http://www.nature.com/nm/journal/v13/n11/abs/nm1677.html
and: http://cebp.aacrjournals.org/cgi/content/abstract/15/4/711

One of the distinct impacts of Taxotere according to Dr. Petrylak and others in increased macrophage activation, as opposed to the macrophage inhibition described in these two studies.Taxotere also interferes with mitosis leading to the apoptosis of Tregs rapidly proliferating in response to a T cell based immune attack. Taxotere also reportedly counters the bcl-2 anti-apoptosis expression of AIPC cells. The B cell / antibody marking of cancer cell antigens associated with both GVAX and Provenge also leads to cancer cell destruction by macrophages.All of this suggests that there is good theoretical support for the synergistic effects of immunotherapies and Taxotere even if the combination of Asentar and Taxotere causes serious problems. JMHO.