NorthWest Biotherapeutics Inc (NWBO)

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They offered 4 million shares at $5 in 2001
Prior to that there were only 23 million shares outstanding.
So 27 million shares total outstanding in 2001 at $5. Or $135 Million Mkt Cap.
Since then they did 2 reverse splits, decimating shareholders as the stock tanked both times subsequently.

Northwest Biotherapeutics has conducted two reverse stock splits in its history: one on June 28, 2007, and another on September 26, 2012. The cumulative effect of these splits is a 1:240 reverse split, meaning that 240 shares before the first split would be equivalent to 1 share today.

The bottom line is that if you invested $1,200.00 in 2001 , your investment is worth $0.22 cents today.
If you invested $12,000.00 your investment is worth $2.20 today , that's Two Dollars and 20 cents left in your account, total on a $12,000.00 investment.