NorthWest Biotherapeutics Inc (NWBO)

[Chiugray]

My anticipation is that the DCVax technology platform will get its first regulatory approval next week (or very soon afterwards), and that will come to be realized as a major moment in history for cancer patients and cancer therapy over time. To fully appreciate how significant I believe it will be, I want to highlight a post I made over a year ago about the medical science. Best to all Longs.

An excerpt from Post 676902, 3/7/2024

DCVax’s mechanism of action leverages the immune system and therefore is intuitive to doctors
A. All antigens, information
- DCVax uses actual tumor lysate and importantly presents hundreds of DIFFERENT tumor antigens to the immune system
- Other drugs don’t

B. Efficacy, holistic approach
- Diversity in weapons: T cells, B cells, and antibodies
- Diversity in targets: activates unique cytotoxic T cells, helper T cells, B cells, and antibodies to target each different tumor antigen
- Robust immune memory: after killing the cancer, some T cells and B cells will become immune memory cells and remain
- Other drugs don’t

C. Naturally is not toxic
- Immature T cells and B cells travel thru the thymus and spleen. This process naturally screens out and destroys the self-reactive (autoimmune, toxicity) immune cells.
- Other drugs don't

D. Renaissance in how cancer is treated
- Today doctors have a “drug” that does not cure and must balance efficacy against toxicity
- Tomorrow doctors will have a DCVax “vaccine”, so their focus can then include optimizing a total therapy, including quality of life

The prospect of cancer cure is what all cancer patients desire most
A. DCVax as a vaccine
- Creating a more robust immune memory equates to cure and prevention
- Highly efficacious, non-toxic profile
- Other drugs are not

B. DCVax may possibly vaccinate against Second Primary Cancers
- 19% of cancer patients get a second cancer sometime in their life (unrelated to their first cancer). https://pubmed.ncbi.nlm.nih.gov/24857148/
- Dr. Bosch made this interesting point. Many of the tumor antigens found on the GBM tumor lysate were also the same tumor antigens found in other cancers
- Hypothesis is a DCVax enhanced immune memory can protect against other cancers, especially for those with genetic or family predisposition to a certain cancer.
- Other drugs don't