Google AI from this exact search: brain endothelial damage "gadolinium" Gadolinium-based contrast agents (GBCAs) are often used in MRI scans, and while they're generally considered safe when used as directed, there is some evidence that they can cause brain endothelial damage: Details Brain deposition GBCAs can accumulate in the brain, especially in patients with conditions that can cause inflammation or structural brain abnormalities. Chelate structure Linear GBCAs are more likely to cause brain deposition than macrocyclic GBCAs. Symptoms Patients may experience fatigue, brain fog, skin pain, bone pain, and muscle fasciculations. Symptoms can start immediately or up to a month after receiving a GBCA. Toxicity The non-chelated gadolinium that remains in the body can be toxic. FDA investigation In 2015, the FDA announced that it was investigating the risk of brain deposits from repeated GBCA use.