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Monday, 09/30/2024 3:41:23 PM

Monday, September 30, 2024 3:41:23 PM

Post# of 758
Did gadolinium increase COVID damage to smell and taste?


According to findings of a consecutive chain of COVID-19 encephalopathy, there were (i) neuroradiological symptoms (high rate of gadolinium increase in large intracranial arteries), (ii) clinical results (high incidence of headache in patients with severe disease), (iii) biological properties (increased CSF QAlb indicative of disruption in blood-brain barrier), which might imply a pathophysiological mechanism associated with the vessel wall inflammation for development of COVID-19 encephalopathy– the endothelial hypothesis [
79
]. Besides, in a study, a case report was presented related to a pregnant woman with SARS-CoV-2 showing sudden blindness and seizures, proposing the possibility of promoting brain endothelial damage by SARS-CoV-2 infection, inducing the cited neurological complications in the patient. Subsequently, this study reported a COVID-19 patient indicating preeclampsia related to eclampsia versus posterior reversible leukoencephalopathy with no symptoms [
80
]. It is still polemical if the seizure risk is elevated by a previous history of epilepsy in adult patients with COVID-19. Nevertheless, it seems that genetic history is a predisposing factor in infants.


https://www.sciencedirect.com/science/article/pii/S2405650223000436


A 58-year-old right-handed woman presented to a multidisciplinary facial pain clinic in October 2021 complaining of a constant pain in the right side of her face, extending from the right temple down to her right cheek, lip, and side of nose extraorally and including the maxillary teeth and right side of tongue intraorally. The character of the pain consisted of throbbing, burning, and tingling sensations. These pains had been present since contracting coronavirus SARS-CoV-2 in March 2020 during her role as a hospital nurse manager. The coronavirus infection was confirmed with a positive serum antibody test result. The pain she described had never remitted since starting. It had a minimum severity of 7 of 10 on a numerical rating scale but could increase to 10 of 10 at times. Pain was usually worst around 2 am to 5 am in the morning which disturbed her sleep. There were no autonomic or migrainous features and she reported a subjective feeling of numbness on the right side.

During the first few weeks of infection, she lost her sense of smell and taste and neither of these senses had returned at initial presentation or by the end of patient review. She also complained of dizziness and intermittent diplopia. The patient was fit and well with no underlying medical issues and was taking no medication. There was no history of previous facial trauma, recent dental treatment, or other infections such as herpes virus infection. Owing to the pain, she had taken an extended period of sickness leave from her job and was currently not working.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584294/


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731923/



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