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Re: Bourbon_on_my_cornflakes post# 416595

Tuesday, 05/23/2023 3:59:28 PM

Tuesday, May 23, 2023 3:59:28 PM

Post# of 457061
Couple of items to add:

- Dr. Missling repeatedly said that his priority is creating shareholder value

- Patent protection on 2-73 is solid out to 2039.

- Lecanemab screened 8,000 patients down to 1,700 (had to meet specific beta amyloid load and ab40/ab42 ratio requirements) versus 2-73 trial screen 600 down to 509 (or whatever.)

- 2-73 shows impact on beta amyloid and tau...plus a host of other relevant biomarkers such as inflammation

- the reason it took so long to run the p2b/p3 was money (when Dr.Missling took over Anavex was a penny stock with $5K in the bank and $2m in debt) and they added clinics very slowly because they simply could not manage more burn (other may know this but it was new info to me - not the poverty but the pace being dictated by funding, which now seems obvious.)

- Foundations have funded and encouraged PD, Rett, Anglemans, FragileX, etc...they are active and maybe a couple of more foundations will provide funding (and credibility) soon for other indications

If anything else occurs to me then I will post it. Thanks Bourbon.
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