Oncternal Therapeutics Inc (ONCT)

[TechandBio]

-- Interim Phase 1/2 results for zilovertamab plus ibrutinib in MCL presented at ASCO 2022, with ORR of 85% compare favorably to historical single agent ibrutinib data and support moving into Phase 3 Study ZILO-301

-- Interim data from p53-mutated CLL patients in the same Phase 1/2 study showed encouraging activity in sub-group analyses, with landmark PFS of 100% at 36 months, compares favorably to historical PFS for ibrutinib monotherapy

-- Established a clinical trial and supply agreement with Pharmacyclics for the donation of ibrutinib for our global registrational Phase 3 study, ZILO-301, of zilovertamab in patients with MCL, which is on track to be initiated in September 2022

-- Advanced development of ONCT-808, the lead candidate for our autologous CAR-T program targeting ROR1-expressing malignancies, with IND submission on track for later this month

-- Executing IND enabling studies for ONCT-534, the lead candidate in our novel dual-action androgen receptor inhibitor (DAARI) program

-- Extended cash runway guidance to fund operations into the first half of 2024 with $78.9 million in cash and cash equivalents and no debt as of June 30, 2022


ONCT pipeline is showing more promising data than VelsoBio & NBE Therapeutics here is the key & the valuation of where ONCT should be. Abbive wants this pipeline & will make a take over offer sooner than later. The team at ONCT is top notch sesoned vets from some of the top biotech companies in the world. Their Pedigree is next level.

If you take a formula of three buyouts in the last year and change 2.8 Billion Merck on Velsobio & Boehringer Buyout of NBE-Therapeutics for 1.5 Billion & Trillium 2.2 Billion bought by Pfizer Onct is worth north of Billion. Their pipeline is more mature and their top line data is superior. Onct market cap of 67 Million has 20 to 30x ROI potential from these levels.

Merck inks $2.8B VelosBio buyout to snag anti-ROR1 ADC
https://www.fiercebiotech.com › biotech › merck-inks-...

Merck has struck a deal to buy VelosBio for $2.75 billion. The takeover will give Merck control of an antibody-drug conjugate (ADC) that caused objective ...
You've visited this page 5 times. Last visit: 8/21/22


Boehringer inks $1.5B NBE buyout, joining Merck in new ...
https://www.fiercebiotech.com › biotech › boehringer-i...

Boehringer Ingelheim has struck a deal to buy NBE-Therapeutics for €1.2 billion ($1.5 billion) to add a ROR1-directed antibody-drug conjugate


Oncternal therapeutics: Zilovertamab Phase 3 study Ror1 ZILO-301 Kills cancer stem cells. HUGE Improvement Partnered with AbbV better approach then trillium which was bought out by Pfizer for 2.2 Billion for Hematological malignancies cancers. Next we had the 2 ROR1 buyouts last year and half. This stock is about to quantum leap. Under the radar hidden gem. Billion dollar plus market cap in the making. Onct is helping Imbruvica (PCYC) which as bought out by ABBV 21 Billion and has 9 Billion plus in sales. Zilovertamab in combo with Imbruvica is 50% more affective then Imbruvica alone with less side effects. Plus 9 indications in the ONCT pipeline including Prostate & Breast cancer Her2 (39 Billion market for Her2 Breast cancer in 2025 Onct market cap at 65 Million is extremely undervalued. The chart is turning around. Ror1 first in class in the making.
https://www.fiercebiotech.com/biotech/merck-inks-2-8b-velosbio-buyout-to-snag-anti-ror1-adc


This is the most undervalued asset, 'explosive' move coming.

081 - Oncternal Therapeutics Drives Complete Responders with First in Class ROR1 Antagonist

ONCT Team Includes Veterans from Fate therapeutics, Merck, Pfizer, Gilead, Amgen, Johnson & Johnson, Roche, Lilly, & Takeda. Plus the legendary Kipps who was the primary lead investigator for PCYC Imbruvica for 18 years. Which was bought out by ABBV for 21 Billion Kipps then moved to ONCT were now headed into a phase 3 with ABBV for their blockbuster drug Imbruvica is 50% more affective then Imbruvica alone with less side effects. Plus 9 indications in the ONCT pipeline i

ONCT ROR1 Expressed on Multiple
Solid and Liquid Tumors
MCL 95%
CLL 95%
Uterus 96%
Lymphoma 90%
Prostate 90%


Skin 89%
Pancreatic 83%
Adrenal 83%
Lung 77%
Breast 75%
Testicular 73%

https://www.fiercebiotech.com/biotech/abbvie-pens-imbruvica-supply-pact-support-pivotal-oncternal-trial


August 2022 ONCT Biz presentation.
https://investor.oncternal.com/static-files/f7628e1c-42c5-4c8a-8247-e910ad5555c4

ONCT Pipeline.
https://www.oncternal.com/pipeline

About 50 million shares outstanding.
% Held by Institutions 31%
% Held by Insiders 11%
Insiders have been buying over the last few months

$ONCT