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Saturday, 08/07/2021 12:42:32 PM

Saturday, August 07, 2021 12:42:32 PM

Post# of 37493
omnis study funded by 100B company:
Conclusion: The MCII is a relevant measure for
studies of patients with OA because it considers
patient perspectives on clinical improvements. In
this analysis, this criterion was applied to data
from a previously published clinical trial of
patients with OA of the hand for the first time.
Most patients treated with DSG 1% achieved clinically meaningful relief within 1 week that was
sustained for ≥8 weeks. Despite placebo response
rates of 44% to 52%, a significantly higher percentage of patients had MCII responses with
DSG 1%, providing evidence for the efficacy of
DSG.
Acknowledgement/Funding Source: This study
was funded by GlaxoSmithKline Consumer
Healthcare.


GlaxoSmithKline Consumer Healthcare investor in relivatrol study


this implies they a are 100B company funding omnihealths research and an investor in omnihealths future.
References
1. Hochberg MC, et al. American College of Rheumatology 2012
recommendations for the use of nonpharmacologic and
pharmacologic therapies in osteoarthritis of the hand, hip, and
knee. Arthritis Care Res (Hoboken). 2012;64(4):465-474.
2. Bellamy N, et al. Development of multinational definitions of
minimal clinically important improvement and patient acceptable
symptomatic state in osteoarthritis. Arthritis Care Res (Hoboken).
2015 Jul;67(7):972-980.
*C20—Pain Management
A Novel Approach in the Management
of Post-Episiotomy Pain
Yisroel Grabie, OMS II1
; Zara Jamil, OMS II1
;
Joseph Schwob, OMS II1
; Boris Petrikovsky, MD,
PhD1
; Arkady Uryash, MD, PhD1

1
New York Institute of Technology College of
Osteopathic Medicine; 2
Garden OB/GYN; 3
Mount
Sinai Medical Center
Statement of Significance: The first tenet of
osteopathic medicine states: “The body is a unit
the person is a unit of body, mind, and spirit.”
Given that childbirth is a traumatic event for the
mother, in addition to the fact that postpartum
depression rates are considerable, it seems valuable to explore novel pain management resources
using the osteopathic holistic philosophy for the
treatment of postepisiotomy pain. It is our belief
that in treating a mother’s perineal pain, we may
also improve her overall mind and spirit enhancing her wellbeing.
Methods: This pilot study was conducted in an
outpatient obstetrics clinic located in Miami, F.L.
involving postpartum women between the ages of
18-39 years of age, who underwent vaginal delivery with episiotomy. Spray bottles with the investigational product were distributed to the patients
to manage their pain freely without regulation. A
survey to assess postepisiotomy pain using the
Visual Analog Scale (VAS) was administered to
the patients. Pain attenuation, time to pain attenuation, and quality of pain were measured
Data Analysis: Analysis of this preliminary study
indicates that Relivatrol© significantly reduced
postepisiotomy pain. We are currently in the
process of replicating this study on a larger scale
in order to address limitations inherent to the
study’s design.
Results: The cohort consisted of 25 postpartum
women. Of note, there were 5 women who did
not respond to the treatment. The investigational
product attenuated pain by an average of 3.2
scale units. Additionally, in a subgroup analysis
of the “responders”, pain was attenuated by 4.0
scale units. Pre-administration pain quality was
reported as sharp (n=12), achy (n=6), and dull
(n=5). In the participants who responded to treatment, the average time to analgesia was reported
to be 9.25 Average pain ratings after treatment
were compared with average pain ratings before
treatment using a unidirectional paired sample t
test (df=24). The average pain ratings for the
entire cohort (including non-responders) after
administration of Relivatrol© were significantly
lower than average pain rating prior to administration t(24)=7.41, P<.0001.
Conclusion: We concluded that Relivatrol© significantly decreases postepisiotomy pain. Since
this pilot study had multiple limitations, we developed a protocol for a larger investigation involving a greater number of participants, a control
ABSTRACTS

e116 The Journal of the American Osteopathic Association November 2019 | Vol 119 | No. 12
arm, pharmacokinetic parameters, and an analysis
of quality of life impact.
Acknowledgment/Funding Source: None
reported.
References
1. Friedman AM, Ananth CV, Prendergast E, D’Alton ME, Wright
JD. Variation in and Factors Associated With Use of Episiotomy.
Jama. 2015;313(2):197. doi:10.1001/jama.2014.14774.
2. Tsuchiya H. Anesthetic Agents of Plant Origin: A Review of
Phytochemicals with Anesthetic Activity. Molecules. 2017;22
(8):1369. doi:10.3390/molecules22081369.
3. DiGiovanna EL, Schiowitz S, Dowling DJ. An Osteopathic
Approach to Diagnosis and Treatment. Philadelphia, PA:
Lippincott Williams and Wilkins; 2005.
4. Hieger MA, Afeld JL, Cumpston KL, Wills BK. Topical
Benzocaine and Methemoglobinemia American Journal of
Therapeutics. 2017; 24(5):e596-e598.American journal of
therapeutics. 2017;24:e596.