Cel Sci Corporation (CVM)

[Duduza5]

Thanks for the kind words. Feel free to repost to stocktwits.

I crawled out of my dark, social media hole because I think Multikine should get a fair shake. If a drug and a company fail because it is a bad drug I am pleased the process works to protect the patient. In Cel-Sci’s case I am most worried that a (likely) good drug could fail because the complexity and uniqueness of Multikine makes it easy for profiteering to damage the company and prevent it from crossing the finish line. These small drug companies are where our society has chosen to push the medical envelope, unfortunately our current SEC rules do not protect them.

An activated immune system by definition means that cells which have been selected as carrying antibodies or T-cells targeting the desired antigen (in this case cancer cells) can rapidly reproduce to generate an immune response. Chemo is designed to target rapidly reproducing cells and kill them. Any Immunology 410 student would expect chemo to destroy an immune response. If this were phrased as a question on a multiple choice Immunology 410 test the students would almost all answer C: The chemotherapy would adversely affect an immunological, anti-cancer response.

Unfortunately for Cel-Sci their hands were tied at the beginning because they could not ethically design a study without chemo. The decision for +/- chemo can be made at any point, pre-surgery, pre-radiation, post surgery, post radiation. The factors weighing in to this decision are many but include staging and tumor genetic risk factors and tumor morphology. Cel-Sci had zero control over this aspect of the decision-making process.

The FDA knows and understands the whole story. Fortunately for Cel-Sci as part of SOC there is a low risk subgroup which does not receive chemo because the risk of chemo toxicity outweighs its benefit in this subgroup. This subgroup then sent out a strong signal of efficacy that was statistical significant using the primary outcome measure the study was designed to capture.

Anyone who tells you with confidence that the FDA is going to spike this is lying to you or clueless.

People should definitely make their own decisions and know the facts because this remains a risky investment, but I do not believe it is a dumb investment like many want you to believe.

I will probably stop posting soon but thought I could leave you with the below interesting info:

https://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.4550

Cliff notes: Cisplatin prematurely ages a testicular cancer patient 7.5 years.


Cheers