Adaptimmune Therapeutics PLC (ADAP): It is encouraging. I would like to see s...

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Adaptimmune Therapeutics PLC (ADAP)

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Re: jondoeuk post# 108

Thursday, 10/15/2020 9:32:28 PM

Thursday, October 15, 2020 9:32:28 PM

It is encouraging. I would like to see some tumour shrinkage in the patients with SD.

Going forward, there are other ways to improve efficacy. This would include making changes to production (it seems they are in some cases), adding low-dose radiation (this is already being tested in another trial) [1], use of Ox/Cy over Flu/Cy (should improve trafficking to site(s) of disease and modulate the TME), and short-course decitabine (induces cancer-testis antigen expression) [2].

Refs:
1 https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(18)30449-0
2 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139221

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Recent ADAP News

Form 8-K - Current report • Edgar (US Regulatory) • 03/06/2024 12:05:21 PM
Form 8-K - Current report • Edgar (US Regulatory) • 02/27/2024 01:13:31 PM
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Form 8-K - Current report • Edgar (US Regulatory) • 01/31/2024 10:07:50 PM
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Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/17/2024 10:30:50 PM
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Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/17/2024 10:02:11 PM
Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/17/2024 10:01:40 PM
Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/17/2024 10:01:00 PM
Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/12/2024 10:00:46 PM
Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/12/2024 10:00:37 PM
Form 8-K - Current report • Edgar (US Regulatory) • 01/04/2024 12:46:16 PM
Form 8-K - Current report • Edgar (US Regulatory) • 12/06/2023 12:13:01 PM
Form S-8 - Securities to be offered to employees in employee benefit plans • Edgar (US Regulatory) • 11/30/2023 09:16:11 PM
Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 11/08/2023 09:05:43 PM
Form 8-K - Current report • Edgar (US Regulatory) • 11/08/2023 12:37:28 PM
Form 8-K - Current report • Edgar (US Regulatory) • 11/03/2023 08:15:16 PM
Form 8-K - Current report • Edgar (US Regulatory) • 10/31/2023 12:07:38 PM
Form 8-K - Current report • Edgar (US Regulatory) • 08/31/2023 09:19:52 PM
Form 8-K/A - Current report: [Amend] • Edgar (US Regulatory) • 08/10/2023 08:05:32 PM
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Form 8-K - Current report • Edgar (US Regulatory) • 08/09/2023 11:42:57 AM
Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/01/2023 09:00:14 PM
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