Vaxart Inc (VXRT)

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The studies summarized within this section demonstrated that oral administration of VXA-G2.4-NS could elicit substantial antibody responses to norovirus VP1 by ELISA in mice and ferrets. Local immunity could play a very important role preventing infection and disease, and SIgA would likely be the most effective gut immune response to combat a gut pathogen such as norovirus. These studies demonstrate that VXA-G2.4-NS oral delivery generated intestinal SIgA response and superior levels of SIgA to VP1 injectable protein vaccine.