Zynerba Pharmaceuticals (ZYNE)

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The Registrant previously filed the Registration Statements on Form S-8 (File Nos. 333- 207973, 333-216968, 333-223597 and 333-230182) with the Securities and Exchange Commission (the "Commission") to register 5,709,030 shares of Common Stock that were authorized for issuance under the Plan. Upon the effectiveness of this Registration Statement, an aggregate of 7,209,030 shares of Common Stock will be registered for issuance from time to time under the Plan. Pursuant to General Instruction E to Form S-8, the

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