Monday, January 13, 2020 8:58:30 AM
Product Candidates
The next generation of anti-infectives.
We intend to develop and commercialize novel, first-in-class biologic therapies, known as direct lytic agents (DLAs), to treat life-threatening infections, including those caused by drug-resistant pathogens. The increasing prevalence of antibiotic resistance among bacterial pathogens has been widely recognized as an urgent public health threat by the CDC, the WHO and the Infectious Disease Society of America.
Our lead lysin, exebacase (CF-301) is an investigational product candidate that targets Staph aureus, including MRSA strains, which causes serious infections such as bacteremia, pneumonia and osteomyelitis. We have announced positive results from this first-in-patient Phase 2 superiority study of exebacase, which showed clinically meaningful improvement in clinical responder rates among patients treated with exebacase in addition to standard-of-care (“SOC”) antibiotics compared to SOC antibiotics alone. We have developed a novel, engineered variant of exebacase, CF-296, with potential as a targeted therapy for deep-seated, invasive biofilm-associated Staph aureus infections such as prosthetic joint infections. Our research efforts are focused on a broad-based Gram-negative discovery program which aims to identify, optimize and develop DLAs that target deadly Gram-negative pathogens. We have discovered and engineered lysins with potent activity against drug-resistant Pseudomonas aeruginosa (“P. aeruginosa”) bacteria, a major cause of morbidity and mortality in patients with hospital acquired pneumonia and a major medical challenge for patients with cystic fibrosis. We have also discovered a novel class of phage-derived DLAs, known as amurin peptides, which have displayed potent activity against a wide range of Gram-negative pathogens in preclinical studies, including deadly, drug-resistant P. aeruginosa, Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii and Enterobacter cloacae bacteria species.
Recent CFRX News
- Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend] • Edgar (US Regulatory) • 02/14/2024 07:24:05 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 11/15/2023 09:41:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 11/08/2023 09:30:55 PM
- Form 424B3 - Prospectus [Rule 424(b)(3)] • Edgar (US Regulatory) • 11/03/2023 09:08:09 PM
- Form EFFECT - Notice of Effectiveness • Edgar (US Regulatory) • 11/03/2023 04:16:01 AM
- Form S-1 - General form for registration of securities under the Securities Act of 1933 • Edgar (US Regulatory) • 10/30/2023 09:24:34 PM
- Form S-1 - General form for registration of securities under the Securities Act of 1933 • Edgar (US Regulatory) • 10/24/2023 08:06:07 PM
- Form DEFA14A - Additional definitive proxy soliciting materials and Rule 14(a)(12) material • Edgar (US Regulatory) • 10/23/2023 08:05:56 PM
- ContraFect Announces FDA Clearance of CF-370 IND Application to Proceed With Phase 1 Clinical Study • GlobeNewswire Inc. • 10/16/2023 11:30:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 09/29/2023 03:15:52 PM
- Form DEF 14A - Other definitive proxy statements • Edgar (US Regulatory) • 09/25/2023 12:00:18 PM
- ContraFect to Present at the ASM/ESCMID Joint Conference on Drug Development • GlobeNewswire Inc. • 09/19/2023 12:30:00 PM
- ContraFect Announces Submission of IND Application to the FDA for its Development Candidate CF-370 • GlobeNewswire Inc. • 09/18/2023 11:30:00 AM
- Form PRE 14A - Other preliminary proxy statements • Edgar (US Regulatory) • 09/14/2023 08:05:49 PM
- ContraFect to Present at the World Anti-Microbial Resistance Congress 2023 • GlobeNewswire Inc. • 08/28/2023 12:00:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/18/2023 09:10:29 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/14/2023 08:18:22 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/14/2023 08:10:59 PM
- ContraFect Reports Second Quarter 2023 Financial Results and Provides Business Update • GlobeNewswire Inc. • 08/14/2023 12:30:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 07/25/2023 08:33:29 PM
- ContraFect Enters Into a Warrant Exercise Transaction for Proceeds of $9.6 Million • GlobeNewswire Inc. • 06/27/2023 12:30:00 PM
- ContraFect Data Presentations at ASM Microbe 2023 Demonstrate the Power of the Company’s Proprietary Platform to Discover New Agents Targeting Antibiotic-Resistant Gram-negative Pathogens • GlobeNewswire Inc. • 06/20/2023 12:59:00 PM
- ContraFect to Present New Data Demonstrating the Potential Efficacy of Its Engineered Lysins Against Antibiotic-Resistant Pathogens at ASM Microbe 2023 • GlobeNewswire Inc. • 06/08/2023 08:01:00 PM
- ContraFect Reports First Quarter 2023 Financial Results and Provides Business Update • GlobeNewswire Inc. • 05/15/2023 12:00:00 PM
- ContraFect Announces First Patient Dosed in the Phase 1b/2 Study of Exebacase in Patients with Chronic Prosthetic Joint Infections of the Knee • GlobeNewswire Inc. • 04/26/2023 01:00:00 PM
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ILUS Provides Form 10-K Filing Update • ILUS • Apr 17, 2024 9:54 AM
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