Amarin Corp Plc (AMRN)

[hvypilot]

@JL please help (or anyone else who knows)...

Making money is great but saving lives is greater.

I've seen discussions that the likely benefit of taking EPA is the improvement of the EPA/AA ratio. I've seen that the JELIS study cites this number.

In the REDUCE-IT study NEJM supplement index table 4, the increase of EPA in the control group over the placebo group is dramatic. But I don't see "EPA/AA ratio" discussed or cited.

The FDA label and much discussion focus on triglyceride levels. Is EPA/AA ratio more appropriate?

Why do I ask? Mainly for my health and my wife's. I have triglycerides at 140. My doc has already prescribed Vascepa for me.

My wife's lipids are different. Her triglycerides are low, but her LDL-c levels are high. Would Vascepa be appropriate? Or should we test EPA/AA level to find out?

Here is link to NEJM Reduce-it article supplementary index. In table 4 on page 38 see EPA levels in control and placebo group and note the dramatic change. How does this number relate to EPA/AA ratio? Is EPA/AA ratio cited elsewhere in REDUCE-IT results and discussions?

https://www.nejm.org/doi/suppl/10.1056/NEJMoa1812792/suppl_file/nejmoa1812792_appendix.pdf