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Anavex 2-73 and/or Anavex 3-71 as a potent

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georgejjl   Monday, 10/07/19 09:03:50 PM
Re: None
Post # of 232176 
Anavex 2-73 and/or Anavex 3-71 as a potent treatment for FTD, Frontotemporal Dementia

Toward a Glutamate Hypothesis of Frontotemporal Dementia

Quote:
Emerging evidence has shown that FTD is characterized by a series of changes in several neurotransmitter systems, including serotonin, dopamine, GABA and, above all, glutamate. Indeed, several studies have now provided preclinical and clinical evidence that glutamate is key in the pathogenesis of FTD.



Quote:
GABA, which is the predominant inhibitory neurotransmitter in the brain with different functions other that merely counteracting excitatory glutamatergic neurons, has been shown to be impaired in FTD patients.



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449454/

*********************************************************
Quote:
Prior to treatment, the average RSBQ score was 50. After seven weeks on Anavex-2-73, the average score decreased to 35, suggesting a lessening of symptoms. CGI-I scores were significantly correlated with RSBQ scores, suggesting similar improvement; Anavex did not specify values.

Additionally, after seven weeks of treatment, blood levels of the neurotransmitter glutamate decreased significantly, while levels of another neurotransmitter, GABA, or gamma-aminobutyric acid, increased significantly

.


https://rettsyndromenews.com/2019/09/19/preliminary-trial-data-anavex-2-73-rett-syndrome-suggest-safety-efficacy/


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