Sunday, September 29, 2019 11:59:17 AM
____________________________________________________________________________________
Will Anavex Treat Multiple CNS Diseases?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150996290
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150996631
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151220456
Endoplasmic reticulum-mitochondria crosstalk: from junction to function across neurological disorders.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150934998
Anavex mention in paper (from georgejjl)
"Metformin and simvastatin have also been shown, experimentally, to promote autophagy, both supposedly via the activation of AMPK, and are used for the treatment of diabetes and obesity, respectively [55]. Sig-1R agonists are under intense investigation for the treatment of different neurodegenerative diseases, including AD and ALS [15,56,57]. It is actually the combination of receptor activities that may make ANAVEX2-73 an interesting compound for AD therapy [58] and, indeed, this compound is currently in active clinical studies in both neurodevelopmental (Rett syndrome) as well as neurodegenerative diseases (AD, PD)."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468724/
Exosome:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151287414
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151288272
Schwann Cells:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151277990
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151283100&txt2find=schwann
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151284243&txt2find=schwann
Some FYI from the 5/19 10-Q regarding the science.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148704240
From kevli33 - a blast from the past:
Jan 2018 Webcast of " Central Nervous System: Is there a cure for Alzheimer’s on the Horizon? "
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146009833
History and progress of hypotheses and clinical trials for Alzheimer’s disease pub. 8/23/19 (from Greenspam3)
https://www.nature.com/articles/s41392-019-0063-8
Comments on above:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150735844
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150738103
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150738889
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150739265
Fire station analogy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144927755
Anavex MOA described -
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145657588
A nice blog giving an overview of neurotransmitters:
https://poweronpoweroff.com/blogs/longform/a-guide-to-neurotransmitter-balance
Hampel's August 2018 statement on the action of 2-73:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145787370
The Unique Anavex Mechanism of Action and why it works differently than Donepezil
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145634041
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145648700
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146528112
Drug binding and efficacy are not the same :
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=138603679
________________________________________________________________________________________________
Sigma-1:
A2-73 mixed S1R and Muscarinic modulation - not just S1R. (from Investor2014)
Citation from this paper: https://www.google.co.uk/amp/s/www.researchgate.net/publication/11175896_AF150S_and_AF267B_-_M1_muscarinic_agonists_as_innovative_therapies_for_Alzheimer's_disease/amp
The Sigma-1 Receptor in Cellular Stress Signaling (from kevli33)
https://www.frontiersin.org/articles/10.3389/fnins.2019.00733/full
The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke (from georgejjl)
https://academic.oup.com/brain/article/134/3/732/445636
Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo
Published: 2 March 2019 - free full text access now available (from nidan7500 )
https://www.mdpi.com/2073-4409/8/3/211/htm
Dr. James E. Barrett Ph.d., from Drexel Univ. at the Univ. of New England - UNECOM Biomedical Research Seminar
Sigma-1 Chaperones for the Treatment of Pain, Neurodegenerative Disorders and substance Abuse
Pre 084 is among those looked at.
From tradeherpete, comments on the above:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149667334
BDNF, Sigma-1, and Huntington Disease
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149255300
Several recent publicatons:(from Nidan7500)
https://www.frontiersin.org/research-topics/8795/sigma-1-receptor-neuronal-functions-disorders-of-the-nervous-system-and-therapeutic-potential#articles
Sig-1R is an integral endoplasmic reticulum (ER) membrane protein which forms an oligomer and binds a variety of psychotropic drugs.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150365993
Endoplasmic reticulum proteostasis impairment in aging:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150881937
PubMed index of info on sigma-1 receptor from kevli33:
https://www.ncbi.nlm.nih.gov/pubmed/?term=sigma-1+receptor
Sig-1R and exosomes:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=14293179
Deep dive into history of Sigma-1 Receptor - the start of a good discussion by several posters, do read forward from here:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149338341
Comments on the above:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149339271
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=149339973
The Roles of Intracellular Chaperone Proteins, Sigma Receptors, in Parkinson's Disease (PD) and Major Depressive Disorder (MDD).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537631/
Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma1 (s1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative (from georgejjl)
https://www.researchgate.net/publication/46191396_Anti-amnesic_and_neuroprotective_potentials_of_the_mixed_muscarinic_receptorsigma1_s1_ligand_ANAVEX2-73_a_novel_aminotetrahydrofuran_derivative
What the Sigma-1 receptor does:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145690421
What the Sigma-1 receptor is:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145774636
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147249382
Sigma-1 Receptor as a Pluripotent Modulator in the Living System
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147249865
Broad application of the Sigma-1 (from georgejjl)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158303/
Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases.
(2017 article from mapman1010)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603014/pdf/12929_2017_Article_380.pdf
Article 4/23/19
Sigma-1 Agonists Offer Combination Approach to Dementia Symptoms
Research from the past decade suggests that sigma-1 receptors and their encoding gene, SIGMAR1, together act as a therapeutic target for patients with dementia.
Published: April 23, 2019 Contributed by Mikesc
https://www.neurologylive.com/journals/neurologylive/2019/april-2019/sigma1-agonists-offer-combination-approach-to-dementia-symptoms
What may set AVXL 2-73 apart from other S1 receptor agonists.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145782971
November 2018 publication on Sigma-1 - note the dates of publication history starting in 2016:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771390/pdf/CN-16-97.pdf
Dr. Tangui Maurice on the Sigma-1 - 2015 video:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143980208
History of the Sigma-1 Receptor:
molpharm.aspetjournals.org/content/89/1/142
Sigma-1 in Cancer
https://www.ncbi.nlm.nih.gov/pubmed/23988449
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274865/
Myristic acid hitchhiking on sigma-1 receptor to fend off neurodegeneration (fom georgejjl)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827442/
SIGMA-1 RECEPTOR AGONISM: THE NOVEL TREATMENT OPTION IN RENAL DISEASE. Ádám Hosszú
https://docplayer.net/96707227-Sigma-1-receptor-agonism-the-novel-treatment-option-in-renal-disease-adam-hosszu.html
How the Sigma-1 affects every cell in the body:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146258203
_______________________________________________________________________________________________
MUSCARINIC RECEPTORS:
M1 Muscarinic Receptor Activation Rescues ß-Amyloid-Induced Cognitive Impairment through AMPA Receptor GluA1 Subunit. (from georgejjl)
https://www.ncbi.nlm.nih.gov/pubmed/30981860
M1 Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex:(from georgejjl)
https://www.ncbi.nlm.nih.govThi/pubmed/31003787
The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148297709
________________________________________________________________________________________________
PROTEOSTASIS and CELLULAR HOMEOSTASIS:
What is proteostasis?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147258047
"Proteostasis involves the checkup of cellular proteome stability and functionality by heat-shock chaperones and degradation pathways in charge of maintaining the cells free from toxic proteins.
From: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 2017
https://www.sciencedirect.com/topics/medicine-and-dentistry/protein-homeostasis
Sokol gives us scientific studies to support 2-73 restoration of cellular homeostasis:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145694010
The protein folding problem: a major conundrum of science: Ken Dillposted by georgejjl
More on protein folding:
https://physicsworld.com/a/quantum-approach-reveals-faster-protein-folding/
A Delicate Balance: Fluoroquinolones Disrupt Cellular Homeostasis
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150872773
Endoplasmic reticulum-mitochondria crosstalk: from junction to function across neurological disorders.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150934998
_______________________________________________________________________________________________
AUTOPHAGY:
This MOA applies to the aging process in general:
What is autophagy? (from nidan7500) video from Investor 2014.
https://www.news-medical.net/health/What-is-Autophagy.aspx
What is autophagy (from Pennydouble):
https://www.news-medical.net/life-sciences/What-is-Autophagy.aspx
Recent Comments (09/28/19)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150996290
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150996631
Exosomes and Autophagy: Coordinated Mechanisms for the Maintenance of Cellular Fitness
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151304316
Anavex 2-73 As A Psychotropic Drug?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151327577
NEWS!!! March 4, 2019 Third party paper on cellular recycling.
https://www.anavex.com/anavex-life-sciences-reports-publication-of-new-data-that-show-anavex2-73-induces-cellular-recycling-process-linked-to-the-prevention-and-treatment-of-age-associated-diseases/
Access to above paper
https://www.mdpi.com/2073-4409/8/3/211/htm
Summaries of the autophagy paper:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147424647
https://parkinsonsnewstoday.com/2019/03/07/study-reveals-neuroprotective-mechanisms-anavex-2-73/
On autophagy and ageing.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150048309
Eventually, It Will Be Anavex Prophylaxis
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148461516
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148463672
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147257995
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147361303
Modulation of autophagy by BDNF underlies Synaptic Plasticity
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147538457
Now we have the Firetruck and Garbagetruck (from Investor2014):
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147358699
Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147423046
A series of posts on autophgy from georgejjl
#184496 Autophagy and mitophagy in ALS.
#184495 New preclinical data establishes ANAVEX®2-73 as a modulator
#184494 Role of autophagy in the pathogenesis of multiple sclerosis
#184493 Dysregulation of autophagy and mitochondrial function in Parkinson’s disease
#184492 Impairment of the macroautophagy: a possible hallmark of
#184491 Elimination of ß-amyloid plaques via macroautophagy
#184490 Protein Misfolding and Accumulation as Root Cause in Neurodegeneration
First post in series: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147417660
There are no posts mentioning autophagy on this board prior to 2015.
2015 posts mentioning autophagy - one each from georgejjl and TrueTrades:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=118317394&txt2find=autophagy
Link to the entire paper referenced by TrueTrades:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807076/pdf/mol.113.087809.pdf
2016 posts mentioning autophagy - three from georgejjl:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=121979414&txt2find=autophagy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=122985309&txt2find=autophagy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=126356651&txt2find=autophagy
Potential Roles of Mitochondria-Associated ER Membranes (MAMs) in Traumatic Brain Injury (from george jjl in 2017)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=129858549
Autophagy not mentioned again until two posts on 3/9/18 by mapman1010.
It's interesting that it was almost precisely one year before the current paper:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=139184780&txt2find=autophagy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=139185523&txt2find=autophagy
Discussion of the above:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=140322574&txt2find=autophagy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=140431749&txt2find=autophagy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=140576574&txt2find=autophagy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=140709556&txt2find=autophagy
Autophagy other 2018 mentions:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=141039429&txt2find=autophagy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=141231591&txt2find=autophagy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=141689338&txt2find=autophagy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=141909594&txt2find=autophagy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=141925525&txt2find=autophagy
ER–mitochondria signaling in Parkinson’s disease (from mapman's link to article post below)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=142355746&txt2find=autophagy
PDF of the article cited:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832754/pdf/41419_2017_Article_79.pdf
Autophagy and late Alzheimer's:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143131392&txt2find=autophagy
Amateur17 linked to this article on research done in Australia in 2018:
Alzheimer's tied to brain's 'waste removal system'
https://www.medicalnewstoday.com/articles/322857.php
Sokol post touches on the subject and gives a comprehensive overview of research:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143320176&txt2find=autophagy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143320176&txt2find=autophagy
Autophagy was discussed in September 2018 at the New York Academy of Sciences one-day symposium
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=143337580&txt2find=autophagy
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=145735099&txt2find=autophagy
The above links to non public research by Ashutosh Kumar, I found these links:
https://www.eurekalert.org/pub_releases/2018-12/bsp-aam122618.php
More on Dr. Kumar and his line of research:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147423162
Posts on autophagy and mitochondrial dysfunction studies being done by Dr. Ashutosh Kumar
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147422690
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147423162
____________________________________________________________________________________________________________
GABA:
GABA mentioned in the release of the first Rett Syndrome trial results:
"Additionally, after seven weeks of treatment, blood levels of the neurotransmitter glutamate decreased significantly, while levels of another neurotransmitter, GABA, or gamma-aminobutyric acid, increased significantly. A neurotransmitter is a chemical molecule that allows nerve cells to communicate. In Rett syndrome, there tend to be abnormally high glutamate levels and abnormally low GABA levels. As such, these results suggest a “balancing” of neurotransmitter levels."
https://rettsyndromenews.com/2019/09/19/preliminary-trial-data-anavex-2-73-rett-syndrome-suggest-safety-efficacy/
https://rettsyndromenews.com/author/marisa-wexler/
Discussion following the above:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151224598
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151171967
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151226208
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151265068
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151276120
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151324230
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151361598
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151361805
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151364314
Fluoroquinolones, benzodiazapenes, GABA, motochondiral damage:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146867284
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146867900
____________________________________________________________________________________________________________
GLUTAMATE AND GLUTAMINE:
Researching glutamate induced cytotoxicity, article:
https://www.frontiersin.org/articles/10.3389/fncel.2015.00091/full
Plasma Glutamate and Glutamine Levels
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151182940
Plasma Glutamate and GABA
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151364314
____________________________________________________________________________________________________________
BDNF:
"AdministraCon of ANAVEX 2-73 in the Fragile X Fmr1 KO mouse significantly restores hippocampal BDNF expression to the same levels observed in vehicle-treated wildtype mice (p<0.05, KO vehicle vs. KO ANAVEX 2-73)" slide of the presentation below:
http://www.anavex.com/wp-content/uploads/2017/05/Anavex-Angelman-FX-Rett-conference-update-2017-May-2017-final.pdf
What is BDNF?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148132680
ANAVEX 2-73 Normalizes Hippocampal BDNF Expression
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148132992
__________________________________________________________________________________________________________________
ENDOCANNABINOID SYSTEM:
National Institute on Drug Abuse (NIDA/NIH) 2016 pesentation on the endocannabinoid system (>1 hr)
From dadofmarcmax 10/24/18
HOMEOSTATIC NETWORKING: THE ROLE OF PHYTOCHEMISTRY, THE ENDOCANNABINOID SYSTEM AND POTENTIAL FUTURE THERAPEUTICS
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144438361
Comments on Cbd and Anavex from Cbdpotential:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146337883
Cannabanoid receptors
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146262610
dadofmarcmax on endocannabanoid system:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144438361
____________________________________________________________________________________________________________
MITOCHONDRIAL DYSFUNCTION:
see also genetics section
The Role of Mitochondria in Aging and Disease - David Sinclair (from Investor2014)
The Fenton Reaction - one way mitochondria become dysfunctional.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151136991
Mitochondrial Calcium Transport: New Theory of Alzheimer's (from
Talon38)
https://www.biospace.com/article/promising-new-theory-of-alzheimer-s-disease/?utm_campaign=GenePool&utm_source=hs_email&utm_medium=email&utm_content=76437862&_hsenc=p2ANqtz-8aWL2DvavYwbV4lhaeQeHLEaaUjjrwRfm7KDNTaBiSfoLm7tU7lByUOZ-eCzL7toZ-99lhpj7RODeP0pBvgC760FZ2dw&_hsmi=76437862
Commonly prescribed drugs are tied to nearly 50% higher dementia risk in older adults, study says (from kevli33).
https://www.cnn.com/2019/06/24/health/dementia-risk-drug-study/index.html
Mitochondrial dysfunction as a result of drugs and man made environmental toxins:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=142383333
ROS, mitochodira, and 2-73
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=142698154
Protein Misfolding and Accumulation as Root Cause in Neurodegeneration:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=1474176602-73
Misfolded proteins in cardomyopathy:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=148733003
Dangerous medicines and mitochondrial dysfunction:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=142393634
Fluoroquinolones, benzodiazapenes, GABA, motochondiral damage:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146867284
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146867900
Mitochondrial dysfunction, calorie restriction, aging, evolution and genetics:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821041/
Could Disposing of Damaged Mitochondria Treat Alzheimer’s Disease? (from Investor2014)
https://www.alzforum.org/news/research-news/could-disposing-damaged-mitochondria-treat-alzheimers-disease
Autism and Mitochondrial dysfuncution
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147104490
CVD and mitochondrial dysfunction:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=146829394&txt2find=neurotransmitters
Envoiromental and pharmaceutical causes of mitochondrial dysfunction COMT gene:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147602552
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147602754
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=147603103
Recent AVXL News
- Anavex Life Sciences to Present at the H.C. Wainwright 26th Annual Global Investment Conference 2024 • GlobeNewswire Inc. • 09/03/2024 11:30:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/06/2024 09:21:05 PM
- Anavex Life Sciences Reports Fiscal 2024 Third Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 08/06/2024 11:30:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Third Quarter Financial Results on Tuesday, August 6, 2024 • GlobeNewswire Inc. • 08/01/2024 11:30:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 07/30/2024 09:20:53 PM
- Anavex Life Sciences Announces Translational Biomarker Data for ANAVEX®2-73 (blarcamesine) in Fragile X Syndrome (Major Cause of Autism) at the 19th NFXF International Fragile X Conference • GlobeNewswire Inc. • 07/30/2024 11:30:00 AM
- Form S-3 - Registration statement under Securities Act of 1933 • Edgar (US Regulatory) • 07/29/2024 09:21:49 PM
- Results from Anavex Life Sciences Landmark Phase IIb/III Trial of Blarcamesine Presented at Alzheimer's Association Conference • GlobeNewswire Inc. • 07/28/2024 09:00:00 PM
- Anavex Life Sciences to Present at the H.C. Wainwright 5th Annual Neuro Perspectives Virtual Conference • GlobeNewswire Inc. • 06/20/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/17/2024 11:30:10 AM
- Anavex Life Sciences Announces Expansion of Leadership Team • GlobeNewswire Inc. • 05/22/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/17/2024 10:01:00 AM
- Anavex Life Sciences to Present at the H.C. Wainwright 2nd BioConnect Investor Conference at NASDAQ • GlobeNewswire Inc. • 05/14/2024 11:30:00 AM
- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) Urged to Join Class Action - Contact The Gross Law Firm to Learn More • PR Newswire (US) • 05/10/2024 09:45:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/09/2024 08:35:55 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/09/2024 12:00:30 PM
- Anavex Life Sciences Reports Fiscal 2024 Second Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 05/09/2024 11:30:00 AM
- The Gross Law Firm Announces the Filing of a Securities Class Action on Behalf of Anavex Life Sciences Corporation(AVXL) Shareholders • PR Newswire (US) • 05/07/2024 09:45:00 AM
- Form DEFA14A - Additional definitive proxy soliciting materials and Rule 14(a)(12) material • Edgar (US Regulatory) • 05/06/2024 10:03:33 AM
- Anavex Life Sciences Corporation Sued for Securities Law Violations - Contact The Gross Law Firm Before May 13, 2024 to Discuss Your Rights - AVXL • PR Newswire (US) • 05/03/2024 09:45:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Second Quarter Financial Results on Thursday, May 9th, 2024 • GlobeNewswire Inc. • 05/02/2024 11:30:00 AM
- May 13, 2024 Deadline: Contact The Gross Law Firm to Join Class Action Suit Against AVXL • PR Newswire (US) • 04/26/2024 09:45:00 AM
- Contact The Gross Law Firm by May 13, 2024 Deadline to Join Class Action Against Anavex Life Sciences Corporation(AVXL) • PR Newswire (US) • 04/19/2024 09:45:00 AM
- The Gross Law Firm Reminds Shareholders of a Lead Plaintiff Deadline of May 13, 2024 in Anavex Life Sciences Lawsuit - AVXL • PR Newswire (US) • 04/16/2024 09:45:00 AM
Lingerie Fighting Championships Signs Broadcast Deal With Maybacks Global Entertainment • BOTY • Sep 26, 2024 9:00 AM
Maybacks Global Entertainment and Lingerie Fighting Championships Enter Into Broadcast And Revenue Sharing Agreement • AHRO • Sep 26, 2024 8:30 AM
North Bay Resources Commences Operations at Bishop Gold Mill, Inyo County, California; Engages Sabean Group Management Consulting • NBRI • Sep 25, 2024 9:15 AM
CEO David B. Dorwart Anticipates a Bright Future at Good Gaming Inc. Through His Most Recent Shareholder Update • GMER • Sep 25, 2024 8:30 AM
Cannabix Technologies and Omega Laboratories Inc. Advance Marijuana Breathalyzer Technology - Dr. Bruce Goldberger to Present at Society of Forensic Toxicologists Conference • BLOZF • Sep 24, 2024 8:50 AM
Integrated Ventures, Inc Announces Strategic Partnership For GLP-1 (Semaglutide) Procurement Through MedWell USA, LLC. • INTV • Sep 24, 2024 8:45 AM