Amarin Corp Plc (AMRN)

[MedResCollab]

Tastytheelf,

Just for fun (yours in italics):

- EPA doesn't do anything [we never stated this]
- It causes liver damage [evidence suggests that fatty acid ethyl esters, such as Vascepa, after long term use may cause organ damage. We provide evidence of this here: https://www.regulations.gov/document?D=FDA-2019-P-3156-0001 ]
- It does work, but it's just a dietary supplement [it works to lower triglyceride levels, and lower some other markers. It may reduce the risk of ASCVD at 4 g/d, but because the results of REDUCE-IT appear to be confounded, DDI studies would at the least be needed to exonerate mineral oil in the perceived malabsorption of cardiac medications, and/or a new CVOT with an inert placebo conducted. And yes, it's just a dietary supplement.]
- It does work, but DPA is better [we never stated this]
- It does work, but the patents are no good [if by "it does work" you mean at lowering TG and some other markers, yes we advocated that; if by "it does work" you mean reduce risk of ASCVD, see point above; but on the patents, yes we argue they are "no good"]
- It does and doesn't work literally at the same time [that may be true. See points above]

Kind Regards,
-MRC