Wednesday, March 27, 2019 12:46:14 AM
The synergistic effect between compounds is nothing new. Traditional Chinese practitioners have been treating specific problems with herb concoctions for centuries. The concept, while not exact, is similar to the way the entourage effect works. The term “entourage effect” was first used decades ago by two Israeli scientists Shimon Ben-Shabat and Raphael Mechoulam. They realized that cannabinoids found in the cannabis plant actually work in a similar way as the body’s own endocannabinoid system- which is to say that each cannabinoid has a different and beneficial effect in our body. The most notable illustration was seen when AIDS and cancer sufferers were studied as they consumed cannabis which helped ease weight loss and other adverse effects of chemotherapy. In this specific study it was the cannabinoid tetrahydrocannabinol (THC) which was responsible for those benefits but the same patients also reported a heightened psychotropic effect which made them feel “stoned”. Since Cannabidiol (CBD) is known to modulate the effect of THC on the human body, the same dose was blended with it resulting in that same patient group reporting the same benefits minus the unwanted side effect of the THC.
While researchers agree that more studies are needed to understand the entourage effect, many can attest that the heightened efficacy when compounds operate together is real and not imagined. Not only can this be seen between CBD and THC but also in how terpenes and flavonoids increase the cerebral blood flow, impacting the blood-brain barrier; another way in which cannabinoids work together. As research continues, our knowledge will collectively broaden on how cannabis compounds treat a myriad of ailments and diseases. Everyone agrees that as a whole we have only begun to scratch the surface and that the field is wide open for greater exploration and development.
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