2 Insulin Linkage: Type 2 Diabetes (T2D) and AD are linked. With a diagnosis of T2D there is approximately a two-fold increase in the risk of risk of AD. The studiessuggest that diabetes affects the ABeta accumulation in the brain which in turn disrupt the brain’s ability to clear the insulin degrading enzyme. So when the body is not able to regulate blood sugar levels the brain gets starved of the growth factors found in insulin that the neurons are dependent upon. Without having the right balance of growth factors brain cells are very susceptible to death. Prolonged exposure without insulin reduces the brain’s ability to repair the damage. Further evidence suggested that insulin lost its effectiveness as a growth factor as the disease progresses due to the increase in brain insulin resistance. Animal models show that insulin has a protective effectin the progression of AD. This is why oral insulinbeing developed by EastGate Pharmaceuticals (ETBI) might be able to drastically reduce the onset of T2D and AD saving billions in healthcare costs.
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