XenaLives Saturday, 08/04/18 11:41:13 AM Re: tradeherpete post# 161473 Post # of 293654 Recharacterization would be for the point of showing maximum response in the optimal population. I don't think anyone would be discontinued from the drug during P3 though. I think the whole enchilada will probably get approved early, then it all becomes a P4 learning exercise. IMO that could happen before a P3 even begins, depending on strength of reaction. In Peace, In War