Tuesday, July 10, 2018 8:31:20 AM
CANADA NEWSWIRE 6:30 AM ET 7/10/2018
PMN310 Shows Potential for Best in Class Amyloid-Beta Oligomer Selectivity
TORONTO and CAMBRIDGE, MA, July 10, 2018 /CNW/ - ProMIS Neurosciences, Inc.(ARFXF) , a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, today announced that the Company will present preclinical data on its lead product candidate for Alzheimer's disease (AD), PMN310, at the Alzheimer's Association International Conference (AAIC) to be held in Chicago Illinois on July 22-26.
ProMIS Neurosciences Inc. (CNW Group/ProMIS Neurosciences Inc.)
Advances in the understanding of Alzheimer's disease (AD) pathogenesis suggest that progressive neurodegeneration is not caused by plaque but rather by low molecular weight (LMW) soluble toxic amyloid-beta oligomers (AßO). Binding of Aß monomers and/or fibrils by therapeutic antibodies has been associated with suboptimal efficacy and adverse events in clinical trials.
Dr. Elliot Goldstein, ProMIS President and CEO stated: "PMN310 was selected as our lead product for development on the basis of its ability to selectively target and neutralize toxic Aß oligomers with no significant off-target binding to Aß monomers or plaque. In addition to aducanumab, encouraging results have been reported with a second clinical program, BAN2401, targeting toxic forms of Aß. We believe the particular, oligomer selective profile of PMN310 supports a potential best in class profile compared to these other Aß therapeutic antibodies currently showing promising results in clinical trials."
The poster by Kaplan (et al.), is entitled Humanized PMN310 shows enhanced therapeutic potential by binding toxic low molecular weight Aß oligomers while avoiding ARIA-related binding to Aß deposits in AD patient brains. The data shows preferential binding of PMN310 to the toxic oligomer-enriched fraction from AD patient brains compared to other Aß - directed therapeutic antibodies.
Johanne Kaplan, ProMIS Chief Development Officer, commented on the presentation: "Our results to be presented at AAIC indicate PMN310 may provide greater therapeutic potency and safety compared to other Aß-directed antibodies due to its selective targeting of soluble toxic oligomers and the consequently reduced risk of amyloid related imaging abnormalities, or ARIA, allowing for safe administration of higher doses of antibody."
The session and presentation details are as follows:
Poster Session P2-02 – "Therapeutics: Preclinical (nonhuman)", Poster P2-048
Monday July 23, 9:30 AM - 4:15 PM
McCormick Place, Hall F-1
ProMIS is very pleased to contribute to this year's AAIC, the world's largest forum where international investigators, clinicians and care providers gather to share the latest study results, theories and discoveries that will help bring the world closer to breakthroughs in dementia science.
PMN310 is currently in late preclinical development with anticipated start of clinical trials in the second half of 2019.
BAN2401 is a humanized monoclonal antibody for AD, currently in clinical development by Esai/Biogen
About ProMIS Neurosciences, Inc.(ARFXF)
ProMIS Neurosciences (ARFXF) is a development stage biotechnology company focused on discovering and developing antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, in particular Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). The Company's proprietary target discovery engine is based on the use of two complementary techniques. The Company applies its thermodynamic, computational discovery platform—ProMIS™ and Collective Coordinates — to predict novel targets known as Disease Specific Epitopes (DSEs) on the molecular surface of misfolded proteins. Using this unique precision medicine approach, the Company is developing novel antibody therapeutics for AD, ALS and PD. ProMIS is headquartered in Toronto, Ontario, with offices in Cambridge, Massachusetts. ProMIS is listed on the Toronto Stock Exchange under the symbol PMN.TO, and on the OTCQB Venture Market under the symbol ARFXF.
For further information please consult the Company's website at: www.promisneurosciences.com
Follow us on Twitter
Like us on LinkedIn
Neither the TSX nor its Regulation Services Provider (as that term is defined in the policies of the TSX) accepts responsibility for the adequacy or accuracy of this release. This news release contains certain "forward-looking statements" within the meaning of Canadian securities legislation. Forward-looking statements are statements that are not historical facts; they are generally, but not always, identified by the words "expects", "plans", "anticipates", believes", "intends", "estimates", "projects", "aims", "potential", "goal", "objective", "prospective", and similar expressions, or that events or conditions "will", "would", "may", "can", "could" or "should" occur. Forward-looking statements are based on the beliefs, estimates and opinions of the Company's management on the date the statements are made and they involve a number of risks and uncertainties. Consequently, there can be no assurances that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Except as required by the securities disclosure laws and regulations applicable to the Company, the Company undertakes no obligation to update these forward-looking statements if management's beliefs, estimates or opinions, or other factors, should change.
Cision View original content with multimedia:http://www.prnewswire.com/news-releases/promis-neurosciences-to-present-preclinical-data-on-alzheimers-disease-therapeutic-antibody-pmn310-at-alzheimers-association-international-conference-300678205.html
SOURCE ProMIS Neurosciences Inc.(ARFXF)
Recent PMN News
- ProMIS Neurosciences Publishes in the Journal of Biological Chemistry on the Interaction Between Pathogenic Proteins as a Treatment Target for ALS • GlobeNewswire Inc. • 04/09/2024 11:00:00 AM
- ProMIS Neurosciences to Present in Upcoming Investor Conferences in April • GlobeNewswire Inc. • 04/04/2024 11:00:00 AM
- ProMIS Neurosciences Announces Full Year 2023 Financial Results and Recent Highlights • GlobeNewswire Inc. • 04/01/2024 08:15:00 PM
- ProMIS Neurosciences Strengthens Global Intellectual Property Portfolio • GlobeNewswire Inc. • 03/11/2024 11:00:00 AM
- ProMIS Neurosciences to Present at the 2024 BIO CEO & Investor Conference • GlobeNewswire Inc. • 02/22/2024 12:00:00 PM
- ProMIS Neurosciences Achieves Milestone in Development of Therapeutic Alpha-Synuclein Vaccine • GlobeNewswire Inc. • 01/22/2024 12:00:00 PM
- ProMIS Neurosciences Issues Letter to Shareholders • GlobeNewswire Inc. • 01/08/2024 12:00:00 PM
- ProMIS Neurosciences, Inc. Announces Leadership Transition • GlobeNewswire Inc. • 01/03/2024 12:00:00 PM
- ProMIS Neurosciences Announces Publication on Novel Target for ALS • GlobeNewswire Inc. • 12/20/2023 12:00:00 PM
- ProMIS Neurosciences Doses First Subjects in Phase 1a Clinical Trial of PMN310 to Treat Alzheimer’s Disease • GlobeNewswire Inc. • 11/20/2023 12:00:00 PM
- ProMIS Neurosciences Announces Third Quarter 2023 Financial Results and Recent Highlights • GlobeNewswire Inc. • 11/14/2023 09:30:00 PM
- ProMIS Neurosciences Closes $20.4 Million Private Placement Financing • GlobeNewswire Inc. • 09/08/2023 11:00:00 AM
- ProMIS Neurosciences to Present at the H.C. Wainwright 25th Annual Global Investment Conference • GlobeNewswire Inc. • 09/06/2023 04:18:53 PM
- ProMIS Neurosciences Announces $20.4 Million Private Placement Financing • GlobeNewswire Inc. • 08/21/2023 08:12:03 PM
- ProMIS Neurosciences Announces Second Quarter 2023 Financial Results and Recent Highlights • GlobeNewswire Inc. • 08/14/2023 09:33:19 PM
- ProMIS Showcases Preclinical Data at the Alzheimer’s Association International Conference 2023 on Computationally-Derived Antibody and Vaccine from Alzheimer’s Pipeline • GlobeNewswire Inc. • 07/17/2023 11:00:00 AM
- ProMIS Announces Completion of Continuance • GlobeNewswire Inc. • 07/14/2023 11:45:00 AM
- ProMIS Neurosciences to Consolidate Trading on the Nasdaq Exchange • GlobeNewswire Inc. • 07/10/2023 11:55:00 AM
- ProMIS Neurosciences Holds Annual Meeting of Shareholders All Resolutions Approved • GlobeNewswire Inc. • 06/30/2023 12:00:00 PM
- Updated URL to Access ProMIS Annual Meeting of Shareholders on June 29, 2023 at 9:30am Eastern Time • GlobeNewswire Inc. • 06/29/2023 12:00:00 PM
- ProMIS Neurosciences Announces First Quarter 2023 Financial Results and Recent Highlights • GlobeNewswire Inc. • 05/15/2023 09:00:00 PM
- ProMIS Neurosciences Announces FDA Clearance of Investigational New Drug (IND) Application for PMN310 in Alzheimer’s Disease • GlobeNewswire Inc. • 05/08/2023 01:00:00 PM
- Data Presented at American Academy of Neurology Annual Meeting on Novel Vaccine Design for Alzheimer’s Disease • GlobeNewswire Inc. • 04/25/2023 09:00:00 PM
- ProMIS Neurosciences Presents Preclinical Data Highlighting Targeting of Toxic Misfolded Proteins in Alzheimer’s Disease and ALS at American Academy of Neurology Annual Meeting • GlobeNewswire Inc. • 04/24/2023 11:30:00 AM
VPR Brands LP Reports Record Annual Financial Performance for Fiscal Year 2023 • VPRB • Apr 19, 2024 11:24 AM
Coinllectibles' Subsidiary, Grand Town Development Limited, Acquires Rare Song Dynasty Ceramics Worth Over USD28million • COSG • Apr 18, 2024 8:03 AM
ILUS Provides Form 10-K Filing Update • ILUS • Apr 17, 2024 9:54 AM
Glucotrack Announces Expansion of Its Continuous Glucose Monitoring Technology to Epidural Glucose Monitoring • GCTK • Apr 17, 2024 8:00 AM
Maybacks Global Entertainment To Fire Up 24 New Stations in Louisiana • AHRO • Apr 16, 2024 1:30 PM
Cannabix Technologies Begins Certification of Contactless Alcohol Breathalyzer, Re-Brands product series to Breath Logix • BLOZF • Apr 16, 2024 8:52 AM