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Wednesday, 06/13/2018 9:49:28 PM

Wednesday, June 13, 2018 9:49:28 PM

Post# of 682029
Brain Cancer Vaccine Moves Closer to Reality During Clinical Trial

Healthline
~ Ann Pietrangelo - June 13, 2018

https://www.healthline.com/health-news/brain-cancer-vaccine-clinical-trial#5

First part of the article is a rehash of the journal - but the author then quotes two doctors - one is an author, the other is another doctor, an oncologist, from St. Joseph's Hospital in Orange (my area) who must have worked with Dr. Loudon on the trial.

Kesari, one of the study’s authors, told Healthline that this trial has the potential to be a breakthrough.

In addition to a positive improvement in survival, Kesari said the vaccine is safe. It doesn’t have the negative impact on quality of life that some other cancer treatments can.



The interim results are promising, but Kesari cautions that it’s too soon to know for certain.

“We have to wait for more data on the longer period of outcomes. 90 percent of the study participants ended up getting the vaccine, so you can’t compare the two arms,” he continued.

“Survival looks really good. But the real question is: Can we do a study in the future and really randomize patients so the control arm doesn’t get the vaccine? That’s what’s really needed,” said Kesari.



Not sure why he'd think that it's needed in the future... seems rather cruel given how god the interim results are looking.

The oncologist, Timothy Byun, brings up the concern of the cross over.

Byun told Healthline that the study outcome is interesting. But, like Kesari, he suspects the crossover of patients from the placebo arm to DCVax-L on progression may impact the analysis of overall survival.

“It is a well-tolerated therapy, so from [a] safety perspective, I don’t worry much. Since we are still waiting for final data, I don’t know if and when the FDA would approve this therapy,” he said.

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