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Provectus Biopharmaceuticals and Pediatric Oncology Experimental Therapeutics Investigators' Consortium (POETIC) Announce PV-10 Abstract at American Society of Clinical Oncology (ASCO) Annual Meeting

Research undertaken at POETIC member institutions Alberta Children's Hospital (Canada) and Memorial Sloan Kettering Cancer Center identifies PV-10 activity, mechanisms of action, drug synergy, and in vivo activity
Preclinical data support advancing clinical development of PV-10 into early-stage clinical trial for refractory pediatric solid tumors

Thursday May 17, 2018

KNOXVILLE, TN & New York, NY, /GLOBE NEWSWIRE/ -- Provectus and POETIC today announced preclinical PV-10 data from pediatric cancer research that will be presented at the 2018 American Society of Clinical Oncology ("ASCO") Annual Meeting in Chicago, IL.

PV-10 induced cell death in pediatric solid tumor cell lines derived from relapsed pediatric neuroblastoma, Ewing sarcoma, rhabdomyosarcoma, and osteosarcoma with a measurable therapeutic window compared to normal cells. Western blot analyses of cells treated with PV-10 indicated induction of apoptosis. Drug combination studies showed synergy with radiation and agents that target mitosis. Xenograft studies showed significant reduction of tumor burden in PV-10-treated mice compared to control animals, with a corresponding increase in overall survival.

Provectus Biopharmaceuticals, Inc. (OTCQB: PVCT, www.provectusbio.com) ("Provectus" or the "Company") is a clinical-stage biotechnology company developing PV-10 as the first small molecule oncolytic immunotherapy for adult and pediatric solid tumor cancers. The Pediatric Oncology Experimental Therapeutics Investigators' Consortium ("POETIC") is a group of North American academic medical centers developing new pediatric cancer therapies.

Findings will be highlighted in a poster presentation on Saturday, June 2 from 8:00 to 11:30 a.m. CDT in Hall A as part of the Pediatric Solid Tumors topic during the Pediatric Oncology session. The POETIC poster title is "In vitro and xenograft anti-tumor activity, target modulation and drug synergy studies of PV-10 against refractory pediatric solid tumors," the poster board number is 230, and the abstract number is 10557.

This preclinical pediatric cancer research was led by Aru Narendran, MD, PhD and researchers at the POETIC Laboratory for Pre-Clinical and Drug Discovery Studies at the University of Calgary (Canada), together with Tanya Trippett, MD, Director of POETIC and researchers at Memorial Sloan Kettering Cancer Center.

Dr. Trippett said, "POETIC's mission is to promote the early clinical development of promising therapies for the treatment of children, adolescents, and young adults with cancer. We hope our collaboration with Provectus on PV-10 leads to an opportunity to improve cancer care for children around the world."

Ed Pershing, Chair of Provectus' Board of Directors, said, "We are thrilled to work alongside POETIC and its member institutions in Canada and the U.S. in an effort to jointly advance options for pediatric cancer patients around the globe."

The complete press release is available at https://www.provectusbio.com/news/press-releases/provectus-pr-20180517-1 on the Provectus website.