NorthWest Biotherapeutics Inc (NWBO)

[Doc logic]

hankmanhub,

I thought I made myself clear in my original post but if not the point I was trying to make was that I am excited about what I have found but am not willing to get into too much detail. You want the details spelled out and those who want to do harm to NWBO might also want those details spelled out. I had to point out to Pyrrhonian when he went negative on NWBO something about certain cell types that he confessed he was not well informed about. The import of those cell types was later affirmed by a doctor that has been cited several times by posters on this board. The reason I am sometimes obtuse in my comments is that there are those who express concerns about NWBO products that turn out to be irrelevant to this trial at this point in time. They may have been early concerns that were taken care of but are deliberately misleading when brought up bease they are called to our attention to create at least some temporary concern until we figure out that that concern was already dealt with. Does that sound like FUD? Pyrrhonian expressed concerns about DCs matured and processed with freeze thawed lysate being unable to create a significant immune response. Then flipper44 showed him and all of us the DC trains created by low dose administration and reminded him that Dr. Linda Liau and the doctors at NWBO knew more about how to create DC mobility than he did. Another example is when I asked AVII77 to use the data points we have to create a graph comparing 1st half event rates based on PFS, and standard time to death after recurrence, to second half event rates based on the enrollment curve data and data points given. I do not have his expertise in this area or I would attempt it. I did look at the numbers and saw a trend but lack the skills in statistics to clarify with certainty what I was seeing. Linda Powers essentially confirmed that second half event rates had slowed when she spoke at the ASM and I believe AVII77 could demonstrate this in graph form if he wanted to. Do you see where I am going with this? I hope so because I agree with several posters that have already responded to your posts that personal due diligence is key to your understanding and confidence in your investment. Your due diligence may also end up helping others with theirs.

By the way, I will share one observation about the Phase 1 Direct trial that I knew absolutely had to be corrected for any next phase trial. The spacing of treatments is bioligically critical. I knew they had to get initial treatment spacings down to about 2 weeks for full effect. They announced they would do this in their next trial after I had commented on this publicly already. Best wishes.