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Re: DragonBear post# 80904

Tuesday, 02/20/2018 1:33:44 AM

Tuesday, February 20, 2018 1:33:44 AM

Post# of 144811
Doses and doses

All of the patients in the first trial received ifosfamide at a dose of 1 mg/m2, whereas a dose of 2 mg/m2 was given in the second trial according to the label instructions, i.e., on Days 2, 3 and 4 and Days 23, 24 and 25 post capsule administration, plus an isodose of mesna to protect against urotoxicity




Ok. Two three day doses were given in the first trials. Two three day doses.

This time three day doses will be given until there is no longer a response.

So although six injections of ifosfamide were given, Lohr refers to each three days of injections as a single dose.

Gunzburg and Lohr are both right if you overcome the semantics for what constitutes a dose.

So let’s drop the semantics and look at the medicine of the proposed trials.

The key point is that only two ‘three day doses’ were given in the first trial. This time, because of what we know about the caps there will be multiple 3 day doses which should give a much improved result. A weakened tumor should respond better to further doses so reduction in tumors is more likely in this new trial. And more doses should bring more reduction.

Usual dosage of ifosfamide is a dose of 1.2 grams per m2 per day for 5 consecutive days. Treatment is repeated every 3 weeks or after recovery from hematologic toxicity.

In our case only two lots of three consecutive days were involved. With a smaller dose in the second trial.

That’s why it’s pointless citing the responses of the first trial because this trial is very different and designed to be more many times more effective with more doses until the tumor stops responding. Much more likely success than last time.

Add to this the improvement in the ciab which now contain hundreds of times more cells and the activation should be much much greater too.

And vastly improved imaging in the 20 years since the first trial mean we’ll see results clearer and earlier than before. Could we expect t breakthrough therapy after several patients are treated? Very possible if more tumors become operable after treatment with ciab.

And these vastly better results than last time should be without side effects!

Without side effects!

Tumor reduction without side effects?

No one has achieved that yet.

And it will be more affordable than the recent high tech treatments which cost hundreds of thousands of dollars.





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